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Cancer 2010 | Cancer 2009 | Cancer 2007 | Cancer 2006 | Cancer 1990 | Cancer 1980
Cardiology 2010 | Cardiology 2009 | Cardiology 2007 | Cardiology 2004 | Cardiology 1996
Diabetes 2010 | Ear, Nose and Throat 2009 | Gastroenterology 2010 | Genetics/Basic Science Research 2010
Genetics/Basic Science Research 2009 | Genetics/Basic Science Research 1950 | Genetics/Basic Science Research 1996
Genetics/Basic Science Research 1990 | Genetics/Basic Science Research 1980 | Genetics/Basic Science Research 1960
Gerontology 2010 | Gerontology 2009 | Gerontology 2008 | Health Care 2010 | HIV/AIDS 2010 | HIV/AIDS 1990
HIV/AIDS 1987 | HIV/AIDS 1981 | Neurology 2010 | Neurology 2009 | Neurology 2008 | Neurology 2007 | Neurology 2004
Neurology 2003 | Neurology 1996 | Ophthalmology 2010 | Ophthalmology 1990 | Pediatrics 2010 | Pediatrics 2009 | Pediatrics 2008
Pediatrics 1980 | Pharmacology 1998 | Psychiatry/Psychology 2010 | Psychiatry/Psychology 2009 | Psychiatry/Psychology 2008
Radiology 1990 | Radiology 1980 | Radiology 1960 | Radiology 1950 | Radiology 1958 | Radiology 1949 | Respiratory Medicine
Surgery 1985
| Surgery 1984 | Surgery 1970 | Surgery 1976 | Surgery 1975 | Surgery 1964 | Surgery 1956
Virology/Immunology 2010 | Virology/Immunology 2009 | Virology/Immunology 2006 | Virology/Immunology 1982

CANCER 2010

Researchers from the UCLA Jonsson Comprehensive Cancer Center have taken lymphocytes armed with a cancer-fighting virus, and added a “reporter” gene. This gene enabled the scientists to track the genetically engineered lymphocytes using PET scanning. The lymphocytes made their way to the lungs and lymph nodes and then homed in on tumors wherever they were located in the body.

Working with colleagues at the California Institute of Technology, UCLA cancer researchers have found proof that a targeted nanoparticle injected into a patient’s bloodstream, can navigate into tumors, deliver double-strand interfering RNA, and turn off an important cancer gene. In addition, the more nanoparticles sent into the bloodstream, the more of them are found in tumor cells delivering RNA. The study demonstrates the feasibility of using both nanoparticles and RNA interference-based therapeutics in patients.

Researchers from UCLA’s Jonsson Comprehensive Cancer have found that mice lacking an enzyme called deoxycytidine kinase (dCK) have defects in their immune systems. The finding, published in the Proceedings of the National Academy of Sciences, may lead to treatments for autoimmune disorders and cancers of the immune system.

Young adults who have faced and overcome cancer in childhood are four times more likely to develop post-traumatic stress disorder than their siblings who did not face cancer. A UCLA study has shown these patients developed symptoms including phobias, edginess, and extreme anxiety.

A combination of two targeted therapies already shown to be effective in breast cancer has now been shown to offer benefits in treating a subset of gastric cancers with a specific genetic mutation, UCLA cancer researchers have found. The drugs Herceptin and Tykerb, given together, significantly inhibit tumor growth in gastric cancers with amplified levels of HER2, a mutation that causes cancers to become more aggressive. The mutation occurs in between 18 and 27 percent of gastric cancers.

UCLA cancer researchers have found that by monitoring changes in proteins called histones, they can predict how patients with pancreatic cancer will respond to chemotherapy treatment. Histones act as spools around which DNA is wound in the cell nucleus. High levels of certain histones in tumor cells predicted which patients were more likely to benefit from chemotherapy after surgery.

The first complete genomic sequencing of a brain cancer line, an advance that could lead to the development of personalized treatments based on the unique biological signature of each cancer, has been completed by researchers at the UCLA Jonsson Comprehensive Cancer Center. The findings may also improve methods of monitoring brain cancer recurrence.

A multi-disciplinary group of researchers from UCLA demonstrated the usefulness of salivary diagnostics to find an early marker for pancreatic cancer, one of the deadliest forms of the disease. In the study, the researchers successfully linked changes in the molecular signatures found in human saliva to the presence of early-stage pancreatic cancer.

Researchers from UCLA and the West LA VA Medical Center developed a new assessment tool that can help guide treatment of pancreatic cysts based on probable outcome, and patients’ views about aggressive treatment vs. quality of life.

A joint UCLA-RAND study has shown that patients with a common type of colon cancer, especially older patients, often do not receive the aggressive chemotherapy treatment that can lead to better survival. Latest findings call for surgery to remove the cancer, followed by chemotherapy to “lock” patients into a cancer-free state.

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CANCER 2009

UCLA physicians demonstrated that by using PET scanning with CT scanning, they can determine the effectiveness of chemotherapy after the first round of treatment. Typically patients are screened after three months to determine their response to chemotherapy.

‘Light’ cigarettes actually have nearly the same nicotine level as regular cigarettes, a UCLA study showed.

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CANCER 2007

A UCLA study has shown that some angiogenesis inhibitors, drugs that block a tumor’s development of its own blood supply, may actually lead to heart attack and stroke.

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CANCER 2006

UCLA Jonsson Cancer Center researchers discovered that combining the molecule-targeted therapy Herceptin with chemotherapy significantly improved disease-free survival in women who express the Her-2neu genetic mutation.

Research at UCLA Jonsson Cancer Center demonstrated that drinking an eight-ounce glass of pomegranate juice daily improved the PSA levels of men being treated for prostate cancer by nearly four times.

UCLA radiologists collaborated with Siemens Medical Solutions to develop a software program that enables an imaging expert to log onto a personal computer and operate an MRI machine by remote control. UCLA researchers found that the quality of the remote scans was superior to onsite scans by a less experienced technologist.

UCLA researchers determined that select patients over the age of 65 can safely undergo lung transplantation and have acceptable outcomes. The study negates the theory that older adults should not be considered for transplantation due to lower survival rates.

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CANCER 1990

UCLA physician Dr. Dennis Slamon discovered the relationship between the HER-2/neu gene and an aggressive form of breast cancer. This discovery led to the development of an antibody called Herceptin. The FDA approved Herceptin for use as a single agent and in combination with the chemotherapy drug taxol on Sept. 25, 1998, making it the first approved treatment to attack cancer at the genetic level.

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CANCER 1980

Dr. Judith C. Gasson, director of the UCLA Jonsson Cancer Center, and her colleagues purified GM-CSF, the first human growth factor ever purified. The discovery shortened from five weeks to two weeks the time it takes for cancer patients to recover their white blood cell counts after bone marrow transplants.

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CARDIOLOGY 2010

Researchers at the UCLA Cardiac Arrhythmia Center tested two new therapies, thoracic epidural anesthesia and left cardiac sympathetic nerve decline, to treat life-threatening cardiac arrhythmias. The study found that the procedures were well-tolerated, and may offer an alternative in arrhythmia treatment.

A new UCLA study compared the benefits and risks of heart bypass surgery, a major medical procedure, with those of angioplasty including insertion of a wire mesh stent, a less invasive procedure with a much faster recovery time. After reviewing the results of eight studies run over nine years, UCLA researchers found that the risk of death after one year was the same. In addition, risk of stroke was lower in stent patients, but the risk of developing new clots over time was significantly lower in bypass patients.

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CARDIOLOGY 2009

A UCLA study showed that the LDL cholesterol levels of nearly 75 percent of patients hospitalized for heart attack were within the normal range. The study suggests that lowering cholesterol guideline targets may reduce the number of patients who are hospitalized for heart attack.

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CARDIOLOGY 2007

Researchers at UCLA found that a simple blood test taken at hospital admission can strongly predict in-hospital mortality for heart failure patients. The test will be useful in helping doctors determine which patients need more intensive monitoring and treatment.

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CARDIOLOGY 2004

A UCLA study showed that the use of the drug statin reduced mortality among patients with heart failure by more than 50 percent.

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CARDIOLOGY 1996

UCLA’s Dr. Hillel Laks pioneered the country’s first alternative heart transplant, and was the first U.S. cardiac surgeon to perform bypass surgery on a donor heart prior to transplantation.

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DIABETES 2010

Dieting to control weight is not enough to prevent type 2 diabetes. Sarcopenia – low skeletal muscle mass and strength – still puts people at risk for this condition. Exercise and diet work best together to prevent the disease.

A new study has shown that metformin, a drug often used to treat diabetes mellitus, is safe for treating patients with both diabetes and advanced heart failure. This may affect over 2 million patients with both conditions, since diabetes increases the risk of heart disease.

Sarcopenia – low muscle mass and strength – common in obese and older people, was thought to put individuals at risk for developing Type 2 diabetes. A UCLA study has shown that sarcopenia is associated with insulin resistance in both obese and non-obese people, and with diabetes in obese individuals. Dieting on its own is not enough to protect people from diabetes; muscle mass and strength are also important.

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EAR, NOSE AND THROAT 2009

A UCLA study showed for the first time how microscopic crystals located on hair-like cilia in the ear govern hearing and balance.

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 GASTROENTROLOGY 2010

Researchers at UCLA and Canada’s McGill University have demonstrated structural changes in specific brain regions in female patients with irritable bowel syndrome. The condition, which causes pain and discomfort in the abdomen, is generally agreed to represent an alteration in brain-gut interaction.

A UCLA-RAND study showed that obese women who undergo bariatric surgery for weight loss before becoming pregnant reduce their risk of pregnancy-related complications and give birth to healthier babies.

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GENETICS/BASIC SCIENCE RESEARCH 2010

UCLA researchers have identified two cellular proteins that play a key role in hepatitis C virus infection. A new drug targeting these two proteins could help treat hepatitis C in a method that is less toxic to patients. The researchers hope to block the two proteins, and hopefully eliminate the chance for hepatitis C to grow in the body.

A new UCLA study has shed light on how genes interact with environmental factors to cause disease. The researchers studied thousands of genes at rest and under stress simulated by fats that incite inflammation. Their findings underscore the fact that genetic studies must consider the intersection of genes with their environment.

Stem cell researchers at UCLA discovered a pattern in DNA methylation (the addition of a methyl group to DNA), an event that affects cell function when gene expression is changed by the altered DNA. The study has implications for future work on cancer and stem cell lines.

In 2007, a gene allele associated with obesity was expressed in half of Americans from European ancestry. Now, UCLA researchers have found that the same allele, which is also carried by one-quarter of U.S. Hispanics, 15 percent of African Americans, and 15 percent of Asian Americans, may also cause brain tissue loss. This puts more than a third of the U.S. population at risk for neurological diseases such as Alzheimer’s.

Participating in the largest DNA scan for familial autism, UCLA researchers have identified new genetic changes present in as many as 20 percent of autistic children but only rarely in their parents. The study confirms that the autistic children carry individual genetic mutations that are unique to them, which contribute to their susceptibility to autism.

The genetic mutation of a gene called neurofibromin causes neurofibromatosis type 1, or NF1, the most common cause of learning disabilities. Building on this research, a UCLA research team has shown that the protein controlled by neurofibromin controls the release of a neurotransmitter called GABA, and that too much GABA in the brain interferes with working memory. The study suggests a potential drug target to correct NF1-related disorders.

A common gene allele associated with weight gain and obesity called FTO, carried by roughly half of Americans, has been shown to play a role in loss of brain tissue associated with diseases like Alzheimer’s. Loss of brain tissue in FTO carriers was shown to be as high as 20 percent, and can increase as body weight rises. The UCLA study was published in the Proceedings of the National Academy of Sciences.

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GENETICS/BASIC SCIENCE RESEARCH 2009

Gene therapy can be developed as a safe and effective once-only weapon against HIV, according to a UCLA study. The first-of-its-kind study was shown to reduce viral load and help preserve the immune system.

Gene therapy can be developed as a safe and effective once-only weapon against HIV, according to a UCLA study. The first-of-its-kind study was shown to reduce viral load and help preserve the immune system.

Working with colleagues from 30 different research institutions across the country, UCLA researchers have identified a new gene variant that is highly common in autistic children. The study showed that this gene, CDH10, is most active in brain regions that support language, speech, and social behavior.

Researchers at UCLA and colleagues collaborated to pinpoint the genetic mutation responsible for severe childhood epilepsy.

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GENETICS/BASIC SCIENCE RESEARCH 1950

UCLA researcher Dr. William N. Valentine discovered the underlying cause of a group of illnesses known as hemolytic anemias that are characterized by excessive destruction of red blood cells.

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GENETICS/BASIC SCIENCE RESEARCH 1996

UCLA physicians started a national cystic fibrosis carrier screening study that led to the first nationwide molecular genetic screening program.

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GENETICS/BASIC SCIENCE RESEARCH 1990

UCLA’s Dr. Ernest Noble first identified a gene associated with severe alcoholism. This breakthrough marked the first time a genetic link to alcoholism was clearly established, although it had been suspected for years. Dr. Noble also linked the same gene, the A1 allele of the D2 dopamine receptor, to additional addictive behaviors such as cocaine and other drug use.

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GENETICS/BASIC SCIENCE RESEARCH 1980

Dr. Owen Witte of UCLA showed that the gene BCR-ABL plays a critical role in the origin of several kinds of human leukemia.

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GENETICS/BASIC SCIENCE RESEARCH 1960

UCLA researchers developed the glass knife ultratome, which opened the modern era of electron microscopy. With the ability to reliably prepare specimens that could be viewed at 100,000 power, medical researchers were able to discover the cellular basis of major diseases including hypertension, diabetes and autoimmune disorders.

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GERONTOLOGY 2010

Researchers at UCLA have found that more than a third of drinkers 60 years and older consume alcohol in excessive amounts, or in amounts that can interfere with their diseases or medications. This is a high-risk behavior that can lead to accidents or other health problems.

Falling down is one of the greatest risks to senior citizens’ health. However, fewer than half of seniors who have a fall see a doctor afterwards, according to a study from the UCLA Center for Health Policy Research. As a result, steps that could prevent future falls are not implemented in half the cases where they could be of benefit.

A new UCLA study has shown that, among seniors, women and patients with dementia are most likely to exceed their Medicare Part D prescription drug coverage annual limit before catastrophic coverage kicks in. According to the UCLA study, patients in these vulnerable groups should be counseled on how best to manage costs by taking steps such as switching to generic or alternative drugs, or stopping use of non-essential medications.

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GERONTOLOGY 2009

UCLA researchers determined that select patients over the age of 65 can safely undergo lung transplantation and have acceptable outcomes. The study negates the theory that older adults should not be considered for transplantation due to lower survival rates.

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GERONTOLOGY 2008

UCLA researchers determined that select patients over the age of 65 can safely undergo lung transplantation and have acceptable outcomes. The study negates the theory that older adults should not be considered for transplantation due to lower survival rates.

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HEALTH CARE 2010

Researchers from UCLA found that patients living in low-income communities reduced their blood pressure and improved their overall health more when given phone assistance to set up physician appointments than did those seen in person by a community nurse. The researchers believe the improvement was a result of the fact that the phone-assisted patients saw a physician and had medications sooner than did those working with the nurse.

Children with special health needs are less likely to receive the family-centered care they need if they are African-American or Latino, or live in a household where English is not the primary language. Areas shown to have the greatest disparities in care for these minority groups include time with the child’s primary health care provider, and receiving care sensitive to the family’s values and customs.

According to a new UCLA study, older women who are no longer or have never been married have twice the rate of their married peers of being uninsured. Women ages 50 to 64 begin to develop more chronic and accelerated health issues like diabetes, heart disease, and asthma. However, as they near the age of retirement, women’s insurance status may change as well.

A new UCLA study looked at methods to help low-income immigrant patients maintain long-term improvement in their blood pressure. The first group was twice as likely to improve their condition if they got help making follow-up physician appointments from a member of the research group. In comparison, the second group assigned to meet with a community nurse who offered more detailed health counseling as well as follow-up appointment scheduling, were less likely to keep blood pressure within healthy limits.

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 HIV/AIDS 2010

Researchers at the UCLA AIDS Institute have successfully removed a cell receptor called CCR5, which plays a role in HIV infection but is not needed by the body, from human cells. The findings point to a new treatment for HIV that would have minimal toxicity for patients.

The development of a safe and effective vaccine for HIV would not ensure that those at risk for contracting the virus would be able to access the drug, or would choose to do so, a UCLA study shows. Fears about the vaccine’s effectiveness and potential side effects may be stumbling blocks to widespread acceptance.

Researchers from the UCLA AIDS Institute successfully removed CCR5 – a cell receptor to HIV-1 that binds to cause infection but which the human body does not need – from human cells. Individuals who naturally lack the CCR5 receptor have been shown to be resistant to HIV infection. The findings provide evidence that prompting long-term reduction of CCR5 can be an effective way to treat patients infected with HIV.

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HIV/AIDS 1990

UCLA cancer researchers demonstrated the benefit of giving AZT to HIV-infected pregnant women in order to prevent fetal infection during pregnancy. This regimen has become a national standard of care, reducing the mother-to-fetus transmission rate from 24 percent to less than five percent.

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HIV/AIDS 1987

UCLA researcher Dr. Irvin Chen and colleagues were first to identify, clone and characterize brain-derived HIV-1.

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HIV/AIDS 1981

UCLA physicians identified the world’s first cases of AIDS.

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NEUROLOGY 2010

A common heart medication can also reduce the risk of developing Parkinson’s disease, UCLA researchers and colleagues have found. The medication, a specific sub-class of dihydropyridine, was associated with a 26 to 30 percent decrease in the risk of Parkinson’s.

People battling multiple sclerosis (MS) have a lifetime risk as high as 50 percent for developing depression. Researchers at UCLA have now found a physical link between MS and depression. In a recent study, atrophy of a certain area of the hippocampus, a brain center responsible for mood and memory, was shown as the probable cause.

UCLA researchers have shown that brain cells grown in culture can be trained to “keep time.” The team stimulated brain cells with simple patterns lasting from a 20th of a second to half a second, and observed a measurable change in the cellular networks’ response, helping to explain how the brain tells time.

Early non-invasive testing and consideration of surgery provide the best outcomes for children with tuberous sclerosis complex (TSC). In the past, recommended treatment involved invasive testing with electrodes inserted into the brain, and medications.

A hospital study led by UCLA researchers showed that care and clinical outcomes for acute stroke patients significantly improved at hospitals that follow approved guidelines to improve care. Quality of outcomes improved from 72 percent to 93 percent in hospitals following the approved guidelines to treat stroke patients, compared to those that did not.

UCLA researchers have verified the existence and recorded the activities of “mirror neurons” in the brain for the first time. Mirror neurons fire both when we perform tasks, and when we observe the performance of others. This “mirroring” is the neural mechanism by which the actions, intentions, and emotions of others can be understood, and which allows us to differentiate our actions from the actions of others.

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NEUROLOGY 2009

Clinical trials showed that a unique nerve-stimulation device can reduce the number of seizures experienced by patients with intractable epilepsy by more than 50 percent.

In a recent study, UCLA researchers and colleagues demonstrated how the compounds in red wine may reduce the development of Alzheimer’s disease. According to the study, compounds in red wine called polyphenols block the formation of the toxic plaques thought to destroy brain cells, and to reduce the toxicity of existing plaques.

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NEUROLOGY 2008

In a recent study, UCLA researchers and colleagues demonstrated how the compounds in red wine may reduce the development of Alzheimer’s disease. According to the study, compounds in red wine called polyphenols block the formation of the toxic plaques thought to destroy brain cells, and to reduce the toxicity of existing plaques.

For the first time, UCLA researchers discovered a link between sleep apnea and memory loss. The study showed that apnea patients had tissue loss in the same regions of the brain that store memory.

Researchers at UCLA and colleagues collaborated to pinpoint the genetic mutation responsible for severe childhood epilepsy.

Among middle-aged to older adults, searching the Internet activates brain centers that control decision-making and complex reasoning. Taking part in this kind of activity may help exercise and improve brain function as we age, the UCLA study showed.

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NEUROLOGY 2007

UCLA researchers used innovative brain scan technology with a new imaging molecule developed at UCLA to show that the abnormal brain protein deposits that define Alzheimer’s disease can be detected early in people with mild cognitive impairment. This new diagnostic tool may help identify those at risk perhaps years before symptoms become obvious.

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NEUROLOGY 2004

The FDA approved the first device to treat acute ischemic stroke. Developed and patented by UCLA physicians, the corkscrew-like device allows doctors to mechanically remove stroke-causing clots from a patient’s brain.

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NEUROLOGY 2003

An international consortium led by neuroscientists at UCLA introduced the first form and function atlas of the adult human brain in health and disease. The decade-long project involved data compiled from anatomical studies, computer modeling, and scanning.

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NEUROLOGY 1996

Researchers at the School of Medicine showed for the first time that brain metabolism and function change as a result of behavior therapy, just as they do with drug therapy, for the treatment of obsessive-compulsive disorder.

UCLA physician Dr. Arnold Scheibel and colleagues were the first to demonstrate the impact of education and metal activity on brain structure and complexity.

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OPHTHALMOLOGY 2010

Kicking the smoking habit, even over the age of 65, can reduce the risk of macular degeneration, a UCLA study has shown. Macular degeneration is the leading cause of blindness in Americans over age 65.

Patients with eye cancer often face a threat to their vision when undergoing radiation treatment for the disease. UCLA researchers have shown that a substance called silicon oil can shield the eye and protect vision in patients undergoing radiation therapy for ocular melanoma.

A national survey conducted by researchers from UCLA and Wayne State found that only 21 percent of Americans suffering from depression receive appropriate treatment; half receive no treatment at all. Treatment rates are significantly lower among minority populations.

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OPHTHALMOLOGY 1990

A decade of UCLA research showed that povidone-iodine is a safe, effective, and less expensive topical alternative to antibiotics in the prevention and treatment of eye infections.

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PEDIATRICS 2010

A new study by researchers at UCLA and Brigham and Women’s Hospital in Boston suggests that improved air quality over the past decade has resulted in fewer cases of ear infections in children. The results may validate the impact of the Clean Air Act of 1990, according to researchers.

Despite facing seizures, learning and cognitive difficulties, and social stigma, children with epilepsy most often rate their own quality of life on a par with their healthy siblings. A UCLA study has shown that while parents rated their epileptic children lower on 10 of 12 health measures, the children themselves see their lives and health as close to normal.

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PEDIATRICS 2009

UCLA researchers demonstrated that an FDA-approved drug called rapamycin reverses the mental retardation caused by tuberous sclerosis complex. The study results may indicate a new research path for autism as well.

Among middle-aged to older adults, searching the Internet activates brain centers that control decision-making and complex reasoning. Taking part in this kind of activity may help exercise and improve brain function as we age, the UCLA study showed.

A UCLA study reported that only about half of children diagnosed with attention deficit disorder actually show the cognitive defects associated with the condition. The study also showed that in populations where medication is rarely prescribed to treat ADHD, the prevalence and symptoms of the disorder are roughly equivalent to populations in which medications are widely used.

Researchers at the Mattel Children’s Hospital at UCLA found that low-dose antidepressant therapy can significantly improve the overall quality of life for adolescents suffering from irritable bowel syndrome.

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PEDIATRICS 2008

Researchers at the Mattel Children’s Hospital at UCLA found that low-dose antidepressant therapy can significantly improve the overall quality of life for adolescents suffering from irritable bowel syndrome.

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PEDIATRICS 1980

UCLA pediatric gastroenterologist Dr. Marvin Ament was the first to implement total parenteral nutrition (TPN), or intravenous feeding, in a child. His work established the first pediatric TPN program in the nation at UCLA, and it remains the nation’s largest such program.

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PHARMACOLOGY 1998

UCLA pharmacologist Dr. Louis J. Ignarro was one of three scientists awarded the Nobel Prize in Physiology or Medicine for showing that nitric oxide helps the body regulate key functions such as blood pressure, and helps prevent blood clots that can cause strokes.

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PSYCHIATRY/PSYCHOLOGY 2010

UCLA research has shown that the families of military personnel deployed into combat may experience stress just as the deployed parent does in readjusting to home life. The studies showed that the number and length of repeated deployments cause higher levels of anxiety that persist even after the deployed parent has returned.

A multi-site study led by UCLA researchers has shown that behavior therapy is as effective as drugs in treating Tourette’s syndrome. The behavior therapy, called comprehensive behavioral intervention for tics, effectively reduces the spasms associated with Tourette’s, without the side effects often resulting from medications.

UCLA researchers have determined that the brains of people with body dysmorphic disorder have abnormalities in processing visual input. The study found that the same systems of the brain are overactive in obsessive-compulsive disorder, suggesting a link between the two conditions.

UCLA researchers have discovered what they describe as a biochemical link between misery and death. In addition, they identified a specific genetic variation in some individuals that seems to disconnect that link, rendering them more biologically resilient in the face of adversity. More important in the long term, the researchers have developed a unique strategy for finding and confirming gene-environment interactions.

Using structural magnetic resonance imaging, UCLA researchers showed for the first time that individuals whose mothers abused methamphetamine during pregnancy, with or without alcohol use, had structural brain abnormalities. In addition, these abnormalities were more severe than those seen in children whose mothers abused alcohol alone.

UCLA psychiatrists have identified a non-invasive way to identify patients who may have a negative response, including suicidal thoughts, as a result of taking antidepressant medications. The researchers used quantitative electroencephalography to identify a link between worsening mental status and specific changes in brain function as soon as 48 hours after a patient begins a course of antidepressant medications.

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PSYCHIARY/PSYCHOLOGY 2009

In the first study of its kind, UCLA researchers showed that post-traumatic stress syndrome, depression, and anxiety run in families. The study followed survivors of a massive earthquake in Armenia to prove that there is a genetic component to these mood disorders.

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PSYCHIATRY/PSYCHOLOGY 2008

In the first study of its kind, UCLA researchers showed that post-traumatic stress syndrome, depression, and anxiety run in families. The study followed survivors of a massive earthquake in Armenia to prove that there is a genetic component to these mood disorders.

A UCLA study reported that only about half of children diagnosed with attention deficit disorder actually show the cognitive defects associated with the condition. The study also showed that in populations where medication is rarely prescribed to treat ADHD, the prevalence and symptoms of the disorder are roughly equivalent to populations in which medications are widely used.

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RADIOLOGY 1990

Researchers in the UCLA Department of Radiation Oncology were the first in the United States to use the gamma-knife for stereotactic irradiation of intracranial tumors and malformations.

Current radiation therapy treatment plans are based largely on UCLA radiation oncology studies that clarified the biology of “dose fractionation.” The findings demonstrated that varying the size of each day’s x-ray dose could improve the responses of cancerous tissue while sparing normal tissue.

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RADIOLOGY 1980

UCLA scientists Dr. Michael Phelps and Edward Hoffman developed the first functional PET (positron emission tomography) system for the scanning of patients, and the first commercial PET scanning system. PET is the only diagnostic imaging technique that provide scientists and physicians with images of the biology and metabolic changes of the body.

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RADIOLOGY 1960

Drs. Paul Crandall and Richard Walter developed the first EEG telemetry unit at UCLA, and were the first to establish a system for recording spontaneous seizures in epileptic patients.

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RADIOLOGY 1950

UCLA faculty member Dr. William Oldendorf laid the scientific groundwork for the noninvasive imaging technologies known as computer-assisted tomography (CAT) and magnetic resonance imaging (MRI). His work with intravenous injection of gamma-emitting radionucleotides led to the development of single photon computerized emission tomography (SPECT), a highly effective and essentially noninvasive method for following physiological change within the body or brain.

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RADIOLOGY 1958

UCLA researchers developed the first techniques for fetal monitoring.

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RADIOLOGY 1949

Dr. Benedict Cassen of the UCLA Department of Radiology developed the rectilinear scintillation scanner, an instrument that made possible the construction of a chart to accurately pinpoint the location and concentration of radioisotopes in the body.

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RESPIRATORY MEDICINE

A new study by UCLA scientists has shown that even brief exposure to ultra-fine particles found near freeways is enough to boost the tissue inflammation that exacerbates asthma. Air pollution particles one-thousandth the width of a human hair incited inflammation deep in the lungs.

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SURGERY 1985

The removal of kidney stones was accomplished non-surgically with a lithotripter for the first time on the West Coast at UCLA Medical Center.

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SURGERY 1984

Dr. Ronald W. Busuttil performed the first liver transplant on the West Coast, establishing UCLA’s Liver Transplant Program. Today it is one of the largest liver transplant centers in the world.

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SURGERY 1970

The UCLA Kidney Transplant Registry, established by Dr. Paul Terasaki is the largest in the world. The data on more than 100,000 kidney recipients submitted from some 200 transplant centers enable doctors to monitor transplant patient outcomes over time.

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SURGERY 1976

The first total shoulder replacement was performed at UCLA.

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SURGERY 1975

The first durable artificial hip, called the “chamfer cylinder design surface,” was developed at UCLA Medical Center.

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SURGERY 1964

UCLA’s Dr. Paul Terasaki developed the microcytotoxicity test that has become the international standard for tissue typing. All kidney, heart, liver, pancreas, heart/lung and bone marrow donors and recipients have been typed using this test.

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SURGERY 1956

The first open-heart surgery in the western United States was performed at UCLA Medical Center.

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VIROLOGY/IMMUNOLOGY 2010

UCLA researchers have identified two cellular proteins that are important in the development of hepatitis C virus, which affects between 270-300 million worldwide. The finding shows that blocking these two proteins can reduce the level of virus in infected patients and improve their recovery.

UCLA researchers have developed a PET-scanning probe that, when used in combination with more common probes, reveals a much clearer picture of an immune response in action. The new probe, FAC, measures the activity of a distinct biochemical pathway. Used with an existing probe that shows glucose metabolism, FAC may be useful in evaluating therapies that target different cellular components of the immune system.

A virus called vesicular stomatitis virus, or VSV, has long been studied as a model for understanding other viruses that cause influenza, measles, and rabies. VSV can also be genetically modified to serve as a highly effective anti-caner agent. Now, UCLA researchers have decoded the architectural organization of the entire bullet-shaped virus. The findings could help lead to advances in the development of VSV-based vaccines for several deadly viruses.

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VIROLOGY/IMMUNOLOGY 2009

A UCLA study showed that chronic insomnia disrupts one of the two hormones responsible for regulating hunger signals in the body. Insomnia has long been associated with poor health and obesity.

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VIROLOGY/IMMUNOLOGY 2006

The first multi-generational bone marrow transplant took place at UCLA. During this groundbreaking procedure, a child with severe combined immunodeficiency (SCID) received bone marrow from her sister, who had received a curative transplant from her father two years earlier.

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VIROLOGY/IMMUNOLOGY 1982

Dr. Irvin Chen was the first to molecularly characterize the human T-cell leukemia virus. This finding resulted in a test that is now used routinely in blood banks around the world to screen for the presence of this virus in human blood donations.

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