John Adams, MD

Research focuses on basic and translational aspects of vitamin D synthesis, metabolism and molecular mode of action.

Grants:
1. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family - RO1 AR37399-22 NIH/NIAMS
2. Vitamin D and Barrier Function - RO1 AR050626-04 NIH/NIDDK
3. Clinical Research Curriculum Award- K30 HL04526-03 NIH/NHLBI
4. Role of Vitamin D in the Innate Immune Response to Tuberculosis - RO1 AI073539-01 NIH/NIAID
5. Imaging-Based Disease Model for Understanding Bone Health - RO1 EB009306-01 NIH/NIBIB
6. Orthopaedic Wear Debris, Vitamin D and Innate Immunity - R21 AR056885-01 NIH/NIAM

Positions:
Vice Chair of Research, Department of Orthopaedic Surgery
Director, Orthopaedic Hospital Research Center
Professor of Orthopaedic Surgery, Medicine and Molecular, Cell and Developmental Biology

• 2009 Council, American Society for Bone and Mineral Research
• 2008 Associate Editor, Journal of Bone and Mineral Research 
• 2007 Standing Member, Skeletal Biology Development and Disease Study Section, NIAMS 
• 1999-2007 Alfred Jay Firestein Chair in Endocrinology, Diabetes and Metabolism
• 2005 ASBMR Frame Award for Clinical Excellence in Bone and Mineral Metabolism
• 1992-2004 Editorial Board Member, Endocrinology
• 2003 External Advisory Committee for i) Mayo Clinic PPG and ii) Univ. of Indiana PPG 
• 2002 Association of American Physicians    
• 1999-2002 Member, Scientific Program Committee, Endocrine Society
• 1999-2002 Member, Scientific Program Committee, Joint AFMR, APOR and GCRC Clinical Research Meeting
• 1999-2002 Member, GCRC Program Directors’ Executive Council
• 1998-2002 Standing Member, Orthopedic Study Section, NIAMS
• 1996 Editorial Board Member, Journal of Clinical Endocrinology and Metabolism
• 1989-1995 Editorial Board Member, Journal of Bone and Mineral Research
• 1991 Western Association of Physicians
• 1987-1991 Standing Member, Veterans Administration Career Development Award Study Section 
• 1982-1984 USC/Orthopaedic Hospital, Eleanor Barry Research Scholarship
• 1983 Young Investigator Award, American Society for Bone and Mineral Research 1990 American Society for Clinical Investigation
• 1975-1978 Mustala, Haden and Housestaff Research Awards, University of Kansas School of Medicine
• 1973 Alpha Omega Alpha

Patents:

• 2009 pending "Vitamin D as a Defensin"
• 2008 US 7,335,735B2, "Intracellular Estradiol Binding Protein"
• 1997 US 08/797,358, “Intracellular Vitamin D Binding Protein”
• 1997 US 08/799,428, “Estrogen Response Element Binding Protein”
• 1997 US 08/799,429, “Vitamin D Response Element Binding Protein”

1. Liu PT, Stenger S, Krutzik SR, Ochoa MT, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin D–mediated human antimicrobial response. Science. 311:1770-1773, 2006.
2. Chen H, Hewison M, Adams JS. Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element binding protein. J Biol Chem. 281:39114-39120, 2006.
3. Wu S, Ren S, Nguyen L, Adams JS, Hewison,M. Splice variants of the CYP27b1 gene and regulation of 1,25-dihydroxyvitamin D3. Endocrinology. 148: 3410-3418, 2007.
4. Adams JS, Chun R, Chen H, Hewison M. Substrate and enzyme trafficking as a means of regulating 1,25-diydroxyvitamin D synthesis and action. J Bone Min Res. 22:V20-24, 2007.
5. Adams JS, Hewison M. Unexpected roles for vitamin D. Nature Clin Pract Endocrinol Metab. 4:80-90, 2008.
6. Chen H, Hewison M, Adams JS. Control of estradiol-directed gene transactivation by an intracellular estrogen binding protein and an estrogen response element binding protein. Mol Endocrinol. 22:559-569, 2008.
7. Geller JL, Adams JS. Vitamin D therapy. Curr Osteoporos Rep. 6:5-11, 2008
8. Liu N, Nguyen L, Chun RF, Ren S, Wu S, Hollis B, DeLuca HF, Adams JS, Hewison M. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology. 149:4799-4808, 2008
9. Chen H, Clemens TL, Hewison M, Adams JS. Estradiol mediates rescue of the dominant-negative effects of the estrogen response element binding protein in vivo. Endocrinology. 150:24-29-2435, 2009
10. Krutzik SR, Liu PT, Hewison M, Stenger S, Adams JS, Modlin RL. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J Immunol. 181:7115-7120, 2008
11. Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M. Vitamin D-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 182:4289-4295, 2009
12. Montoya D, Cruz D, Teles RMB, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. (in press)