Percy Lee, MD

Translational research; Molecular imaging in cancer therapy; Functional Image-guided radiation therapy; Stereotactic body radiation therapy; Multi-modality cancer therapy combining targeted therapy and radiation therapy; Anti-angiogenic therapies

BIOSKETCH

Percy Lee, M.D. is a specialist in radiation oncology at the UCLA Jonsson Comprehensive Cancer Center, Department of Radiation Oncology.   His areas of clinical expertise and interest include lung cancer, cancers of the digestive tract, brain tumors, and prostate cancer. His expertise also includes the use of PET/CT scans for biologically-based radiation treatment planning, the use of 4-Dimensional CT scans to manage tumor and organ motion, as well as delivering highly precise external beam radiation therapy using intensity-modulated radiation therapy (IMRT). In addition, he is interested in developing novel ways of utilizing stereotactic body radiation therapy and image-guided radiation therapy to improve radiation treatment outcomes.

His research interests are primarily translational: They include developing novel molecular imaging platforms for the use in radiation therapy planning, multi-modality treatments in cancer by combining targeted therapy and radiation therapy, as well as anti-angiogenic drugs for cancer therapy.

Dr. Lee attended the Johns Hopkins University and graduated with the highest general and departmental honors, majoring in Biomedical Engineering. He attended Harvard Medical School and the Harvard-MIT Health Science and Technology program where he received his M.D., and graduated Magna cum laude. Dr. Lee completed internship in internal medicine at the Massachusetts General Hospital in Boston. He then completed specialty training in Radiation Oncology at the Stanford University School of Medicine, where he also served as Chief Resident.

He currently serves as an Assistant Professor in the Department of Radiation Oncology at the David Geffen School of Medicine at UCLA. Throughout his training and career, Dr. Lee has earned a number of awards for his clinical and research accomplishments. In addition, he has published in a number of prestigious peer-reviewed journals on topics in his areas of expertise. His primary goals are to provide the highest quality of care for his patients, as well as advancing the current treatment paradigms in cancer therapy.

On a personal note, Dr. Lee is a native of Arcadia, California, a suburb of Los Angeles County. It has been his long-time aspiration to practice radiation oncology near his hometown and to serve the communities that he has grown fond of.

• AACR/ASCO Vail Clinical Trials Workshop: Methods in Clinical Cancer Research
• American Society for Therapeutic Radiology and Oncology Annual Meeting Travel Grant
• 2007 RSNA Roentgen Resident/Fellow Research Award
• Howard Hughes Medical Institute Research Training Fellowship for Medical Students
• Richard J. Johns Award for Outstanding Achievement in Biomedical Engineering
• American Association for Cancer Research (AACR) Science Education Award

1. Lee, P., Chan, C., Paulmurugan, R., Chan, D., Hua, A., Gambhir, S., Le, Q.T., and Giaccia, A. Noninvasive Monitoring of Ligand-dependent VEGF Receptor-2 Dimerization with Split Firefly Luciferase. (in preparation).

2. Xie, Y., Chao, M., Lee, P., and Xing, L. Automated Rectal Contouring Algorithm for Adaptive Radiation Therapy Using Feature-based Registration. Medical Physics, in press (2008).

3. Lee, J., Viakhireva, N., Cesca, C., Lee, P., Kohler, S., Hoppe, R.T., and Kim, Y. Clinico-pathologic Features and Treatment Outcomes in Woringer-Kolopp disease: Review of a Case Series. Journal of the American Academy of Dermatology (2008) Jun.

4. Lee, P., Weerasuriya, D.K., Lavori, P.W., Quon, A., Hara, W., Maxim, P.G., Le, Q.T., Wakelee, H.A., Donington, J.S., Graves, E.E., and Loo, B.W. Metabolic Tumor Burden Predicts for Disease Progression and Death in Lung Cancer. International Journal of Radiation Oncology*Biology*Physics (2007) Oct; 69(2): 328-33.

5. Tran, P.T., Zheng, S., Lee, P., Lavori, P., Husain, A., Teng, N., and Kapp, D.S. Prognostic Factors for Primary Squamous Cell Carcinoma of the Vagina Treated with Radiation. Gynecologic Oncology (2007) Jun; 105(3): 641-9.

6. Feldner, J., Becker, T., Goishi, K., Schweitzer, J., Lee, P., Schachner, M., Klagsbrun, M., and Becker, C.G. Neuropilin-1a is Involved in Trunk Motor Axon Outgrowth in Embryonic Zebrafish. Developmental Dynamics (2005) Nov; 234(3): 535-49.

7. Goishi, K., Lee, P., Davidson, A.J., Nishi, E., Zon, L., and Klagsbrun, M. Inhibition of Zebrafish Epidermal Growth Factor Receptor Activity Results in Cardiovascular Defects. Mechanisms of Development (2003) Jul; 120(7): 811-22.

8. Lee, P., Goishi, K., Davidson, A.J., Mannix, R., Zon, L., and Klagsbrun, M. Neuropilin-1 is Required for Vascular Development and is a Mediator of VEGF-dependent Angiogenesis in Zebrafish. Proceedings of the National Academy of Sciences of the United States of America (2002) Aug; 99(16): 10470-5.

9. Miao, H.Q., Lee, P., Lin, H., Soker, S., and Klagsbrun, M. Neuropilin-1 Expression by Tumor Cells Promotes Tumor Angiogenesis and Progression. The Journal of the Federation of American Societies for Experimental Biology (2000) Dec; 14(15): 2532-9.

10. Bellows, D.S., Chau, N., Lee, P., Lazebnik, Y., Burns, W.H., and Hardwick, J.M. Anti-apoptotic Herpesvirus Bcl-2 Homologs Escape Caspase-mediated Conversion to Pro-apoptotic Proteins. Journal of Virology (2000) Jun; 74(11): 5024-31.