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Donald Kohn, MD

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Donald Barry Kohn, MD
Specialty
Pediatric Hematology-Oncology
Gender Language Spoken
Male English
Hospital Affiliation
Ronald Reagan UCLA Medical Center
Santa Monica-UCLA Medical Center and Orthopaedic Hospital
State License Number
G60297
Contact
(310) 794-1964
Fax Number
(310) 267-2774
Email Address
dkohn@mednet.ucla.edu
PRACTICE LOCATION

Mailing Address:

Departments of MIMG and Pediatrics
University of California, Los Angeles
290D BSRB
615 Charles E. Young Drive South
Los Angeles CA 90095

MEDICAL BOARD CERTIFICATION
Pediatrics, American Board of Pediatrics, 1988
EDUCATION
Fellowship
Allergy & Immunology, National Cancer Institute, 1985 - 1987
Residency
Pediatrics, University of Wisconsin Hospitals and Clinics, 1983 - 1985
Internship
Pediatrics, University of Wisconsin Hospitals and Clinics, 1982 - 1983
Medical Degree
MD, University of Wisconsin Medical School, 1982
MORE INFORMATION
Research Interest

Gene Therapy Using Hematopoietic Stem Cells, Primary Immune Deficiency Diseases, Sickle Cell Disease, Immunotherapy for Leukemia and Cancer

Links
http://www.mimg.ucla.edu/faculty/kohn/index.html
Awards & Recognition
  • 2000-2007 Doris Duke Charitable Foundation Distinguished Clinical Scientist Award Recipient
  • 1996-2001 Elizabeth Glaser Scientist Award from the Pediatric AIDS Foundation
  • 1993 Western Society for Pediatric Research Ross Young Investigator Award
  • 1989-1991 March of Dimes Basil O’Connor Fellowship Award
Publications

(Selected from >180):
1. Nolta JA, Kohn DB. Comparison of the effects of growth factors on retroviral vector-mediated gene transfer and the proliferative status of human hematopoietic progenitor cells. Human Gene Therapy 1:257-68, 1990.
2. Kohn DB, Weinberg K, Nolta, J, et al. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nature Medicine, 1:1017-23, 1995
3. Kohn DB, Hershfield MS, Carbonaro D, et al. Selective accumulation of T lymphocytes with a normal ADA gene four years after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. Nature Medicine 4:775-80, 1998.
4. Kohn DB, Bauer GH, Valdez P, et al. A clinical trial of retroviral-mediated transfer of an RRE decoy gene into CD34+ cells from the bone marrow of HIV-1 infected children. Blood 94:368-71, 1999.
5. Halene S, Wang L, Cooper R, Rockstoce DC, Robbins PM, Kohn DB. Improved expression in murine hematopoietic and lymphoid cells after transplantation of bone marrow transduced with a modified retroviral vector. Blood 94:3349-57,1999.
6. Podsakoff GM, Engel BC, Carbonaro DA, Choi C, Bauer G, Selander D, Csik C, Wilson K, Betts M, Koup K, Nabel G, Bishop K, King S, Church J, Kohn DB. Selective survival of peripheral blood leukocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34+ cells. Mol Ther 12:77-86, 2005.
7. Hollis RP, Nightingale SJ, Pepper KA, Yu X-J, Barsky L, Crooks GM, Kohn DB. Stable gene transfer to human CD34+ hematopoietic progenitor cells using the sleeping beauty transposon. Exp Hematol, 34:1333-1343, 2006.
35. Engel BC, Podsakoff GM, Ireland J, Smogorzewska M, Carbonaro DA, Wilson K, Shah A, Kapoor N, Sweeney M, Borchert M, Crooks G, Weinberg K, Parkman R, Rosenblatt H, Wu SQ, Hershfield M, Candotti F, Kohn DB. Gene therapy of ADA-SCID complicated by trisomy 8 mosaicism. Blood 109:503-506, 2007.
8. Carbonaro DA, Jin XY, Yu XJ, Skelton D, Mi T, Dorey F, Kellems RE, Blackburn M, and Kohn DB. Neonatal Bone Marrow Transplantation of ADA-Deficient SCID Mice Results in Immunological Reconstitution Despite Low Levels of Engraftment and an Absence of Selective Donor T Lymphoid Expansion. Blood 111:5745-5754, 2008.
9. Kohn DB and Candotti F. Gene therapy fulfilling its promise. N Engl J Med, 360:518-521, 2009.

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