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Jian Yu Rao, MD


Jian Yu Rao, MD

UCLA Physician Jian Yu Rao, MD specializes in Anatomic Pathology & Clinical Pathology.
Anatomic Pathology & Clinical Pathology
Language Spoken
English, Chinese
Hospital Affiliation
Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica
State License Number
(310) 825-8940

10833 Le Conte Ave 13-188 CHS
Los Angeles, CA 90095

Cytopathology, American Board of Pathology, 2002
Anatomic Pathology & Clinical Pathology, American Board of Pathology, 1998
Cytopathology, UCLA School of Medicine, 1998 - 1999
Urology, University of Oklahoma College of Medicine, 1987 - 1992
Pathology & Laboratory Med., UCLA School of Medicine, 1994 - 1998
MD, Shanghai Medical University, 1984
Department Affiliation
Provider, Endocrine Surgery Program
Research Interest

Develop tools for cancer screening and early detection

Dr. Rao's lab is interested in developing tools for cancer screening, early detection, and therapeutic monitoring.

Technical Research Interest:

Biomarkers for cancer early detection and screening

The research in my laboratory is focused on developing biomarkers that can be used for individual risk assessment, early detection, and therapeutic monitoring of cancer. To reach this goal, we have two specific research areas.

The first area of research is to study the molecular basis of tumor morphogenesis, we focus our effort on investigating how cytoskeletal proteins, specifically the microfilament actin and the associated binding proteins, are altered in tumorigenesis. We hypothesize that since tumor cells have morphological features that are distinctive from normal cells, and since actin family proteins play important roles in regulating cell morphology, adhesion, as well as motility, investigating these protein changes during tumorigenesis will not only provide molecular insight for tumor morphology, but at the same time develop surrogate markers that are more sensitive and specific than morphological analysis alone. Since actin network is regulated by multiple complex oncogenic signal transduction events, including Ras superfamily small G proteins Rac/Rho/Cdc42, and Src family proteins, and many of these proteins have been developed as the potential therapeutic targets, it is possible that an actin centric strategy for cancer detection/monitoring/prevention/therapy can be developed in he future.

Our second area of research is to develop approaches that can be used to detect early malignant lesions, especially cancer of the breast, bladder, and prostate. The detection of low stage malignant and premalignant lesions is essential for the successful halt, or even the reversion of malignant progression through chemoprevention strategy. The focus will be to develop simple, high throughput techniques that can be used to detect expressional abnormalities of multiple genes on a small sample volume basis. One specific example is to develop Quantitative Fluorescence Image Analysis (QFIA) as a single-cell proteomic method for biomarker analysis on cytological materials.

Additional Information

JianYu Rao is an Associate Professor of Pathology and epidemiology. He is a surgical pathologist and cytopathologist specialized in genitourinary tract and gynecological pathology. He is also a molecular epidemiologist and cancer cell biologist.

He did his training of Anatomic and Clinical pathology as well as Cytopathlogy here at UCLA from 1994 to 1999. He became the faculty at Department of Pathology and Lab Med since 1999.

He is the director of cytopathology research.

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