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Whitney Pope, MD, PhD


Whitney Pope, MD, PhD

UCLA Physician Whitney Pope, MD, PhD specializes in Diagnostic Radiology.
Diagnostic Radiology
Language Spoken
Hospital Affiliation
Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica
State License Number
(310) 267-9783 Office
Fax Number
(310) 825-2776
Email Address
Voted Super Doctor

757 Westwood Plaza, Room 1621E
Los Angeles, CA 90095

Neuroradiology, American Board of Radiology, 2008
Diagnostic Radiology, American Board of Radiology, 2003
Neuroradiology, UCLA School of Medicine, 2003 - 2004
Radiology, UCLA School of Medicine, 1999 - 2003
Internal Medicine, VA Greater Los Angeles Healthcare System, 1998 - 1999
Medical Degree
MD, University of Illinois College of Medicine at Chicago, 1998
Department Affiliation
Physician, Radiology, Neuroradiology
Research Interest
1. Brain tumors, in particular Glioblastoma
2. Physiologic Imaging Biomarkers of Treatment Response
3. Gene Expression (genomics) of Brain Tumor Imaging
Additional Information
Academic / Professional Titles
  • Associate Professor of Radiology, Section of Neuroradiology
  • Director, Radiology Resident Research
  • Assistant Director, Neuroradiology Fellowship Program
Awards & Recognition

1. Brain Tumor Funders' Collaborative Grant for "New Approaches for Developing Tools for Non-Invasive or Minimally-Invasive Monitoring of Pediatric and Adult Gliomas" 2009-2010.

2. Berlex/NER Foundation Fellowship in Basic Science Research Award 2004-05.

3. Johnny Mercer Foundation: Brain Tumor Research Award

Link to PubMed publications »

1. Tsui HCT, Pope WB, Kim CS, Klein WL, Transient expression of adheron molecules during chick retinal development. J Neurobiol. 1992;23:720-738.

2. Pope W, Enam SA, Miller BE, Ghanbari HA, Klein WL. Phosphorylated tau isotope of Alzheimer’s disease is coupled to axonal development in the avian central nervous system. Exp Neurol. 1993;120:106-113.

3. Pope W, Lambert M, Leypold B, Seupaul R, Sletten L, Krafft G, Klein WL. Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human Neuroblastoma cell line SH-SY5Y. Exp Neurol. 1994;126:185-194.

4. Pope W, Sayre J, Perlina A, Villablanca JP, Mischel P, Cloughesy T. Magnetic Resonance Imaging Correlates of Survival in Patients with High Grade Gliomas. Am J Neuroradiol. 2005;26:2466-2474.

5. Morioka C, El-Saden S, Pope W, Duckwiler G, Bui A, Kangarloo H. Integration of HIS/RIS clinical document with PACS image studies for Neuroradiology. Proc SPIE. 2005;5748:318-325.

6. Chen W, Cloughesy T, Delaloye S, Czernin J, Kamdar N, Schiepers C, Pope W, Silverman DH. 18FDOPA PET Imaging of Brain Tumors Comparison Study with 18F-FDG PET and Evaluation of Diagnostic Accuracy. J Nucl Med. 2006;47:904-911.

7. Pope WB, Lai A, Nghiemphu P, Mischel P, Cloughesy TF. MR Imaging in Patients with High Grade Gliomas Treated with Bevacizumab and Chemotherapy. Neurology. 2006;66:1258-1260.

8. Nael K, Ruehm SG, Michaely H, Pope W, Laub G, Finn JP, Villablanca P. High Spatial-Resolution CE-MRA of the Carotid Circulation with Parallel Imaging: Comparison of image quality between two image quality between two different acceleration factors at 3.0T. Invest Radiology. 2006;41:391-399.

9. Nael K, Villablanca JP, Saleh R, Pope W, Nael A, Laub G, Finn JP. Contrast-enhanced MR angiography at 3T in the evaluation of intracranial aneurysms: a comparison with time-of-flight MR angiography. Am J Neuroradiol. 2006;27;2118-21.

10. Nael K, Villablanca P, Pope WB, McNamara T, Laub G, Finn JP. Contrast- enhanced MR Angiography of the Supra-Aortic Arteries at 3.0 Tesla: Highly Accelerated Parallel Acquisition for Improved Spatial Resolution Over an Extended Field of View. Radiology. 2007;242(2):600-609.

11. *Carlson MJ, *Pope WB, Bronstein J, Lai A, Nghiemphu P, Mischel P, Liau L, Nelson S, Cloughesy TF. Relationship between survival and edema in malignant gliomas: role of VEGF and neuronal pentraxin 2. Clin Cancer Res. 2007;13(9):2592-2598. (*authors contributed equally to this work).

12. Chen W, Delaloye S, Geist C, Czernin J, Sayre J, Silverman D, Satyamurthy N, Pope W, Lai A, Cloughesy T. Predicting Treatment Response of Malignant Gliomas to Bevacizumab and Irinotecan by Imaging Proliferation with 18F-FLT PET: A Pilot Study. J Clin Oncol. 2007;25:4714-4721.

13. Nael K, Villablanca JP, Mossaz L, Pope W, Juncosa A, Laub G, Finn JP. 3.0T Contrast-enhanced MR Angiography in Evaluation of Patients with suspected Intracranial Aneurysms: A Comparison with multi-slice CT Angiography. Am J Roentgenol. 2008;190(2):389-95.

14. Nghiemphu P, Green RM, Pope WB, Lai A, Cloughesy TF. Safety of Anticoagulation Use and Bevacizumab in Patients with Glioma. Neuro Oncol. 2008;10:355-60.

15. Lai A, Filka E, McGibbon B, Nghiemphu PL, Graham C, Yong WH, Mischel P, Liau LM, Bergsneider M, Pope W, Selch M, Cloughesy T. Phase II Pilot Study of Bevacizumab in Combination with Temozolomide and Regional Radiation Therapy for Up-Front Treatment of Patients with Newly-diagnosed Glioblastoma Multiforme: Interim analysis of safety and tolerability. Int J Rad Oncol Biol Phys. 2008;71:1372-80.

16. Ananthnarayan S, Bahng J, Roring J, Lai A, Nghiemphu P, Cloughesy TF, Pope W. MR imaging findings in GBM patients during prolonged bevacizumab treatment. J Neuroncol. 2008;88(3):339-47.

17. Morioka C, El-Saden S, Pope W, Sayre J, Duckwiler G, Meng F, Bui A, Kangarloo H. A methodology to integrate clinical data for the efficient assessment of brain-tumor patients. Inform Health Soc Care. 2008:33(1):55-68.

18. Pope WB, Chen JJ, Dong J, Carlson MR, Perlina A, Cloughesy TF, Liau LM, Mischel PS, Nghiemphu P, Lai A, Nelson SF. Relationship between Gene Expression and Enhancement in Glioblastoma Multiforme: an Exploratory DNA Array Analysis. Radiology. 2008;249:268-277.

19. Ledezma C, Chen W, Sai V, Freitas B, Czernin J, Cloughesy T, Pope WB. 18F-FDOPA PET/MRI Fusion in Patients with Primary/Recurrent Gliomas: Initial Experience. Eur J Radiology. 2009 Aug;71(2):242-8. Epub 2008 May 29.

20. Nghiemphu P, Liu W, Lee Y, Than T, Graham C, Lai A, Green RM, Pope WB, Liau LM, Mischel PS, Nelson SF, Elashoff R and Cloughesy TF. Bevacizumab and Chemotherapy for the Treatment of Recurrent Glioblastoma: a Single Institution Experience. Neurology 2009 Apr 7;72(14):1217-22.

21. Pope W, Kim HJ, Huo J, Alger J, Brown MS, Gjertson D, Sai V, Young JR, Tekchandani L, Cloughesy T, Mischel P, Lai A, Nghiemphu P, Rahmanuddin S and Goldin J. ADC Histogram Analysis Predicts Response to Bevacizumab Treatment in Recurrent GBM. Radiology 2009 Jul;252(1):182-9.

22. Harley EM, Pope WB, Villablanca JP, Mumford J, Suh R, Mazziotta J, Enzmann D, and Engel S. Recruitment of Face Selective Cortex Across the Acquisition of Radiological Expertise. Cerebral Cortex 2009 Nov;19(11):2746-54. Epub 2009 Mar 25.

23. Khanlou N, Mathern GW, Mitchell WG, Pope W, Salamon N, Yong WH, Vinters HV. Cortical dysplasia with prominent Rosenthal fiber formation in a case of intractable pediatric epilepsy. Human Path 2009 Aug;40(8):1200-4. Epub 2009 May 8.

24. Huo J, Okada K, Kim HJ, Pope WB, Goldin JG, Alger JR, Brown MS. CADrx for GBM Brain Tumors: Predicting Treatment Response from Changes in Diffusion-Weighted MRI. Algorithms 2009 2(4):1350-1367.

25. Kappadakunnel M, Eskin A, Dong J, Nelson SF, Mischel PS, Liau LM, Ngheimphu P, Lai A, Cloughesy TF, Goldin J, Pope WB. Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. J Neurooncol. 2010 96(3):359-67.

26. Ringman JM, Pope W and Salamon N. Insensitivity of Clinical MRI Interpretation of Medial Temporal Lobe Atrophy in Familial Alzheimer’s Disease. J Neurol 2010 May; 257(5):839-42.

27. Pope W, Itagaki M. Characterizing Brain Tumor Research: The Role of the National Institutes of Health. AJNR Am J Neuroradiol 2010 Apr;31(4):605-9.

28. Pope W, Xia Q, Patton V, Das A, Hambleton J, Kim HJ, Huo J, Brown MS, Goldin J, Cloughesy T. Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab. Neurol 2011;76(5):432-7.

29. Pope WB, A Lai, R Mehta, HJ Kim, J Qiao, JR Young, X Xue, J Goldin, M Brown, P Nghiemphu, A Tran, T Cloughesy. Apparent diffusion coefficent histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma. AJNR Am J Neuroradiol 2011 May;32(5):882-9.

30. A Lai, A Tran, PL Nghiemphu, WB Pope, OE Solis, M Selch, E Filka, WH Yong, PS Mischel, LM Liau, S Phuphanich, K Black, S Peak, RM Green, CE Spier, T Kolevska, J Polikoff, L Fehrenbacher, R Elashoff, T Cloughesy. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol 2011 Jan 10;29(2):142-8.

31. Ellingson BM, Coughesy TF, Lai A, Nghiemphu PL, Michel PS, Pope WB. Quantitative volumetric analysis of conventional magnetic resonance imaging response in recurrent glioblastoma treated with bevacizumab. Neuro-onc 2011 Feb 15 [Epub ahead of print].

32. Ellingson B, KM Schmainda, T Coughesy, PS Michel, A Lai, P Nghiemphu, WB Pope. Graded functional diffusion map (fDM)-defined ADC characteristics predict overall survival in recurrent glioblastoma treated with bevacizumab. Neuro-onc 2011 Aug 19. [Epub ahead of print].

33. Ellingson B, T Coughesy, A Lai, P Nghiemphu, WB Pope. Cell invasion, motility and proliferation level estimates (CIMPLE) maps derived from serial diffusion MRI in recurrent glioblastoma treated with bevacizumab. J Neurooncol. 2011 Mar 26. [Epub ahead of print].

34. Ellingson B, T Coughesy, A Lai, P Nghiemphu, LM Liau, WB Pope. High order diffusion tensor imaging in human glioblastoma. Acad Rad 2011 Apr 30. [Epub ahead of print].

35. Lai A*, S Kharbanda*, W Pope*, A Tran, O Solis, K Pujara, J Carillo, A Pandita, F Peale, B Ellingson, CW Bowers, RH Soriano, S Mohan, WH Yong, WF Forest, S Seshagiri, Z Modrusan, K Aldape, P Mischel, L Liau, C Escovedo, W Chen, P Nghiemphu, CD James, M Prados, M Westphal, K Lamzsus, T Coughesy, H Phillips. IDH1 Mutant Glioblastoma: Evidence for Orchestrated Molecular Evolution from a Developmentally Restricted Cell of Origin. J Clin Oncol (in press;*authors contributed equally to this work).

36. Ellingson B, TF Coughesy, A Lai, P Nghiemphu, WB Pope. Nonlinear registration of diffusion-weighted images improves clinical sensitivity of functional diffusion maps (fDMs) in recurrent glioblastoma treated with bevacizumab. Mag Reson Med 2011 Jun 23. [Epub ahead of print].

37. Ellingson B, TF Coughesy, A Lai, PL Nghiemphu, S Lalezari, T Zaw, K Motevalibashinaeini, PS Michel, WB Pope. Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab. J Neuro-onc Jun 23.

38. Pope WB, L Mirsadraei, A Lai, A Eskin, J Qiao, HJ Kim, BM Ellingson, P Nghiemphu, S Kharbanda, R Soriano, S Nelson, W Yong, H Phillips, T Cloughesy. Differential Gene Expression in Glioblastoma Defined by ADC Histogram Analysis: Relationship to Extracellular Matrix Molecules and Survival. AJNR Am J Neurorad (in press).

39. Schwarzenberg J, Czernin J, Cloughesy T, Ellingson BM, Pope WB, Geist C, Dahlbom M, Silverman DHS, Satyamurthy N, Phelps ME and W Chen. 18F-Fluoro-Thymidine Positron Emission Tomography and MRI for Early Survival Predictions in Patients with Recurrent Malignant Gliomas Treated with Bevacizumab. J Nuc Med (in press).

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