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Arnold Chin, MD, PhD
Arnold I. Chin
Urology
Male
English, Mandarin
Ronald Reagan UCLA Medical Center
A89934
(310) 794-7700 Information and referral
(310) 206-6453
(310) 206-1265
aichin@ucla.edu
Peter Morton Medical Building
200 UCLA Medical Plaza, Suite 140
Los Angeles, CA 90095
Urology, UCLA School of Medicine, 2004 - 2009
Surgery, UCLA School of Medicine, 2003 - 2004
MD, UCLA School of Medicine, 2003
| Bladder Cancer, Hematuria, Prostatitis, Robotic Surgery-Bladder, Urinary Tract Infection (Male) |
Physician, Urology, Minimally Invasive Surgery, Urologic Oncology, Bladder Cancer Program, Kidney Cancer Program, Prostate Cancer Program, Testicular Cancer Program
My clinical expertise includes urologic oncology and renal transplantation, peforming open, laparoscopic, and robotic-assisted surgeries for bladder, kidney, and prostate cancer patients.
Our laboratory studies the tumor microenvironment in prostate and bladder cancer using a combination of animal models, human reconstitution systems, and primary tumor and hematopoietic cells. We are interested in several aspects including the following:
1. Molecular mechanisms in programing tumor-infiltrating lymphocytes. The nature and composition of immune cells in cancer have been linked with tumor grade and overall survival. However, the determinants that lead to immune infiltrating cells in cancer is unclear. We are studying the endogenous signals, innate immune, and adaptive immune pathways that program the composition of the tumor immune microenvironment, and how these will influence tumor proliferation, invasion, and metastasis. We are also interested in how we can reprogram the immune components of the tumor microenvironment to shape tumorigenicity.
2. Mechanisms controlling development and differentiation of cancer stem cells. Cancer initiating cells share similar features to stem cells with their ability for self-renewal and pluripotency. These cell populations may explain the recurrent nature and drug resistance of cancer. We are studying the cell intrinsic signals as well as the cell extrinsic influences from immune and stromal cells of the cancer stem cell in their differentiation, ability to undergo epithelial-to-mesenchymal transition, and development of an invasive phenotype.
Our studies will provide fundamental understanding of the tumor microenvironment, as well as develop therapeutic targets, novel immune-based platforms, and stem cell based therapies against cancer.
Education/Certification
- PhD, UCLA, 2002
Professional Memberships
- American Urological Association
- American Association of Cancer Research
- Society of Urology Oncology
Academic & Medical Staff Appointments
- Assistant Professor Department of Urology, UCLA School of Medicine 2009
- Broad Stem Cell Research Center 2009
- Tumor Immunology Program Area of the Jonsson Comprehensive Cancer Center 2009
- Genitourinary Oncology Program Area of the Jonsson Comprehensive Cancer Center 2009
- STOP Cancer Research Career Development Award 2010
- American Association of Cancer Research Career Development Award for Translational Cancer Research 2010
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