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Linda Baum, MD, PhD
Anatomic Pathology & Clinical Pathology
Female
English
Ronald Reagan UCLA Medical Center
G61523
(310) 825-8940 Information and referral
(310) 206-5985 Office
(310) 206-6329 Lab
lbaum@mednet.ucla.edu
10833 Le Conte Ave 13-188 CHS
Los Angeles, CA 90095
Pathology & Laboratory Med., UCLA School of Medicine, 1987 - 1991
Pathology & Laboratory Med., UCLA School of Medicine, 1986 - 1987
MD, Duke University School of Medicine, 1986
Academic Title: Professor of Pathology and Laboratory Medicine
Department Titles: Medical Director of Clinical Laboratory
Member of California NanoSystems Institute, ACCESS Program: Dept. of Cellular & Molecular Pathology, JCCC Hematopoietic Malignancies Program Area, JCCC Tumor Immunology Program Area
Specialty: Hematopathology, Hematology
Bio:
Linda Baum is an immunologist and pathologist who joined the UCLA Dept. of Pathology and Laboratory Medicine in 1989 as an Assistant Professor. Dr. Baum became a full Professor in 2002. Dr. Baum attended Stanford University, where she received a B.S. in Biology in 1979. She received her Ph.D., with Peter Cresswell in Immunology, and M.D. degrees from Duke University in 1986. Dr. Baum completed her residency in Clinical Pathology at UCLA in 1989, and is Board Certified in Clinical Pathology. She was a post-doctoral fellow in James Paulson's lab during her residency, where she investigated host effects on influenza virus tropism.
As a faculty member at UCLA, Dr. Baum teaches in the Medical School and the Graduate School, and received the Excellence in Education Award. She is the Medical Director of the UCLA Clinical Laboratories and head of the Division of Laboratory Medicine. Her current research focuses on the biochemistry of cell-cell interactions, especially those mediated by protein-saccharide interactions, in immune system and cancer models. She collaborates with UCLA investigators in the California Nanoscience Institute, the Center for Muscular Dystrophy, and the Dept. of Microbiology, Immunology and Molecular Genetics. She is a member of several training programs, including the Hematology/ Oncology, Tumor Cell Biology, and Tumor Immunology programs. She is also a member of the Medical Scientist Training Program Steering Committee, the Jonsson Comprehensive Cancer Center, and the Molecular Biology Institute.
Link to my PubMed publications.
- Nesmelova IV, Ermakova E, Daragan VA, Pang M, Menéndez M, Lagartera L, Solís D, Baum LG, Mayo KH Lactose Binding to Galectin-1 Modulates Structural Dynamics, Increases Conformational Entropy, and Occurs with Apparent Negative Cooperativity. J Mol Biol.. 2010; 397(5): 1209-30.
- Earl LA, Bi S, Baum LG. N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death. J Biol Chem. . 2010; 285(4): 2232-44.
- Pang, M. He, J. Johnson, P. Baum, L. G. CD45-mediated fodrin cleavage during galectin-1 T cell death promotes phagocytic clearance of dying cells. J Immunol. 2009; 182(11): 7001-8.
- Bi S, Baum LG. Sialic acids in T cell development and function. Biochim Biophys Acta.. 2009; 1790(12): 99-610.
- Earl, L. A. Baum, L. G. CD45 glycosylation controls T-cell life and death. Immunol Cell Biol. 2008; 86(7): 608-15.
- Liu, SD; Whiting, CC; Tomassian, T; Pang, M; Bissel, SJ; Baum, LG; Mossine, VV; Poirier, F; Huflejt, ME; Miceli, MC Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes. Blood. 2008; 112(1): 120-130.
- Okumura, C. Y. Baum, L. G., Johnson, P. J. Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis. Cell Microbiol. 2008; 10(10): 2078-90.
- Garner, O. B. Baum, L. G. Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling. Biochem Soc Trans. 2008; 36(Pt 6): 1472-7.
- Nesmelova, Irina V, Pang, Mabel, Baum, Linda G, Mayo, Kevin H H-1, C-13, and N-15 backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer. Biomolecular NMR Assignments . 2008; 2(2): 203-205 .
- Bi S, Earl LA, Jacobs L, Baum LG. Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways. Journal of Biological Chemisty. 2008; 283(18): 12248-12258.
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