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Patrick Kupelian, MD


Patrick Kupelian, MD

UCLA Physician Patrick Kupelian, MD specializes in Radiation Oncology.
Radiation Oncology
Language Spoken
English, French, Arabic, Armenian
Hospital Affiliation
Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica
State License Number
(310) 825-9775 Information and referral
Fax Number
(310) 794-9795
Voted Best Doctor

UCLA Jonsson Comprehensive Cancer Center
200 UCLA Medical Plaza, Suite B265
Los Angeles, CA 90095-6951

Radiation Oncology, American Board of Radiology, 1995, 2004
Radiation Oncology, Cleveland Clinic Foundation, 1994 - 1996
Radiation Oncology, University of Texas - M.D. Anderson Cancer Center, 1990 - 1994
Rotating, American University of Beirut Medical School, 1989 - 1990
MD, American University of Beirut Medical School, 1989
Clinical Trials, General Radiation Oncology, Genitourinary, Intensity Modulated Radiation Therapy (IMRT), Multimodality Cancer Therapy, Prostate Brachytherapy, Prostate Cancer, Stereotactic Body Radiation Therapy (SBRT), Total Body Irradiation (TBI)
Department Affiliation
Vice Chair, Radiation Oncology
Provider, Stereotactic Radiosurgery
Additional Information
Dr. Kupelian is a Professor of Radiation Oncology and Vice-Chair of Clinical Operations and Clinical Research at UCLA. He completed his residency training in radiation oncology at the University of Texas M.D. Anderson Cancer Center in Houston, and completed a fellowship at the Cleveland Clinic Foundation. Following his fellowship, he was the section head of genitourinary malignancies in the Department of Radiation Oncology at the Cleveland Clinic for 8 years. He also served as the Clinical Research Director of the Department of Radiation Oncology at the Cleveland Clinic Foundation. Dr. Kupelian comes to UCLA from M.D. Anderson Cancer Center in Orlando, FL, where he was the Chairman and Scientific Director of Research for Radiation Oncology, and a Professor at the University of Central Florida.

Although he specializes in genitourinary malignancies, he an internationally known expert in the development and evaluation of cutting edge technologies in Radiation Oncology for a variety of anatomic sites. He has pionneered high-dose hypofractionated radiation therapy for prostate cancers. He has also played a significant role in the introduction and implementation of multiple image guidance techniques in radiotherapy. He has authored more than 140 research papers, over 250 abstracts, multiple review papers and book chapters.

He is Board certified in Radiation Oncology. He is a member of the American Society of Therapeutic Radiation and Oncology (ASTRO), the European Society of Therapeutic Radiology and Oncology, American Society of Clinical Oncology, the American Urological Association and the American Brachytherapy society. He has served on many committees within ASTRO. He is a reviewer for several medical journals including International Journal of Radiation Oncology Biology Physics, the Journal of Urology, Radiotherapy and Oncology, Cancer, the Journal of Clinical Oncology, the British Journal of Urology, and Physics in Medicine and Biology. He is active in national and international lecture series. He has conducted multiple educational courses at ASTRO and RSNA among others. He also serves as an examiner at the American Board of Radiology.


1. Lopatiuk-Tirpak O, Langen K, Meeks S, Kupelian PA, Zeidan O, Maryanski M: Performance evaluation of an improved optical computed tomography polymer gel dosimeter system for 3D dose verification of static and dynamic phantom deliveries. Med Phys. 35(9): 3847-59, 2008.
2. Santhanam A, Willoughby T, Shah A, Meeks S, Rolland J, Kupelian PA: Real-time simulation of 4D lung tumor radiotherapy using a breathing model. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv, 11: 710-7. 2008.
3. Langen K, Lu W, Ngwa W, Willoughby T, Chauhan B, Meeks S, Kupelian PA, Olivera G: Correlation between dosimetric effect and intrafraction motion during prostate treatments delivered with helical tomotherapy. Phys Med Biol. 53(24): 7073-86, 2008.
4. Burdick M, Reddy C, Ulchaker J, Angermeier K, Altman A, Chehade N, Mahadevan A, Kupelian PA, Klein E, Ciezki J: Comparison of Biochemical Relapse-Free Survival Between Primary Gleason Score 3 and Primary Gleason Score 4 for Biopsy Gleason Score 7 Prostate Cancer. Int J Radiat Oncol Biol Phys.73(5):1439-45, 2009.
5. Klein E, Ciezki J, Kupelian PA, Mahadevan A: Outcomes for intermediate risk prostate cancer: Are there advantages for surgery, external radiation, or brachytherapy? Urol Oncol. 27(1): 67-71, 2009.
6. Wagner T, Langen K, Meeks S, Willoughby T, Zeidan O, Staton R, Shah A, Manon R, Kupelian PA: Megavoltage Computed Tomography Image-based Low-dose Rate Intracavitary Brachytherapy Planning for Cervical Carcinoma. TCRT, 8(2); 123-130, 2009.
7. Ritter M, Forman J, Kupelian PA, Lawton C, Petereit D: Hypofractionation for Prostate Cancer. Cancer J. 15(1):1-6, 2009.
8. Langen K, Lu W, Willoughby T, Chauhan B, Meeks S, Kupelian PA, Olivera G: Dosimetric Effect of Prostate Motion During Helical Tomotherapy. Int J Radiat Oncol Biol Phys. 74(4):1134-42, 2009.
9. Colon J, Herrera L, Smith J, Patil S, Komanski C, Kupelian PA, Seal S, Jenkins W, Baker C: Selective Radioprotection of Normal Tissues with Cerium Oxide Nanoparticles. Nanomedicine. 5(2):225-31, 2009.
10. Lu W, Chen M, Ruchala K, Chen Q, Langen K, Kupelian PA, Olivera G: Real-time motion-adaptive-optimization (MAO) in TomoTherapy. Phys Med Biol. 23;54(14):4373-4398, 2009.
11. Staton RJ, Langen KM, Kupelian PA, Meeks SL. Dosimetric effects of rotational output variation and x-ray target degradation on helical tomotherapy plans. Med Phys. 36(7): 2881-8, 2009.
12. Santhanam A, Willoughby T, Meeks S, Rolland J, Kupelian PA: Modeling simulation and visualization of conformal 3D lung tumor dosimetry. Phys Med Biol. 54(20):6165-80, 2009.
13. Ngwa W, Meeks S, Kupelian PA, Schnarr E, Langen K: Validation of a computational method for assessing the impact of intra-fraction motion on helical tomotherapy plans. Phys Med Biol. 14;54(21):6611-6621, 2009.
14. Zeidan O, Huddleston A, Lee C, Langen K, Kupelian PA, Meeks S, Manon R: A Comparison of Soft-Tissue Implanted Markers and Bony Anatomy Alignments for Image-Guided Treatments of Head-and-Neck Cancers. Int J Radiat Oncol Biol Phys. 76(3):767-774, 2010.
15. Potters L, Gaspar L, Kavanagh B, Galvin J, Hartford A, Hevezi J, Kupelian PA, Mohiden N, Samuels M, Timmerman R, Tripuraneni P, Vlachaki M, Xing L, Rosenthal S; American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guidelines for image-guided radiation therapy (IGRT). Int J Radiat Oncol Biol Phys. 76(2):319-325, 2010.
16. Foster R, Li H, Kerkhoff A, Enke C, Willoughby T, Kupelian PA, Solberg T. Comparison of transabdominal ultrasound and electromagnetic transponders for prostate localization. J Appl Clin Med Phys. 6;11(1):2924, 2010.
17. Zeidan O, Sriprisan S, Lopatiuk-Tirpak O, Kupelian PA, Meeks S, Hsi W, Li Z, Palta J, Maryanski M. Dosimetric evaluation of a novel polymer gel dosimeter for proton therapy. Med Phys. 2010 May;37(5):2145-52.
18. Thames H, Kuban D, Levy L, Horwitz E, Kupelian PA, Martinez A, Michalski J, Pisansky T, Sandler H, Shipley W, Zelefsky M, Zietman A. The role of overall treatment time in the outcome of radiotherapy of prostate cancer: An analysis of biochemical failure in 4839 men treated between 1987 and 1995. Radiother Oncol. 96(1):6-12, 2010.
19. Min Y, Santhanam A, Neelakkantan H, Ruddy BH, Meeks SL, Kupelian PA. A GPU-based framework for modeling real-time 3D lung tumor conformal dosimetry with subject-specific lung tumor motion. Phys Med Biol. 55(17):5137-50, 2010.

See additional publications as listed in PubMed.gov.

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