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James Yoo, MD


James Yoo, MD

UCLA Physician James Yoo, MD specializes in Colon & Rectal Surgery, Surgery.
Colon & Rectal Surgery, Surgery
Language Spoken
State License Number
(310) 794-7788 Information and referral
Fax Number
(310) 794-1039 Attn: Colorectal Surgery Program

General Surgery Clinic
200 UCLA Medical Plaza, Suite 214
Los Angeles, CA 90095-7302

Colon & Rectal Surgery, American Board of Colon and Rectal Surgery, 2007
Surgery, American Board of Surgery, 2005
Colon & Rectal Surgery, New York Presbyterian Hospital, 2005 - 2006
Colon & Rectal Surgery, New York Hospital - Cornell University Medical Ctr, 2004 - 2005
Surgery, Harvard Medical School, 2000 - 2002
Surgery, Beth Israel Deaconess Med Ctr-East Campus, 1998 - 2004
Surgery, Beth Israel Deaconess Med Ctr-East Campus, 1997 - 1998
Medical Degree
MD, Mt. Sinai School of Medicine, 1997
Anal Sphincter Reconstruction, Colon Cancer, Colon Polyps, Colon Tumor (Benign), Colorectal (colon, rectum and anus), Crohn's Disease, Diverticulitis, Gastric Polyps, Gastrointestinal, Hemorrhoid External, Hemorrhoid Internal, Ileoanal Pull Through, Ilial-Pouch Anal Anastamosis, Laparoscopic Surgery, Minimally Invasive Surgery, Proctocolectomy (Ileal pull through), Rectal Cancer, Rectal Tumor (Benign), Small Bowel Internal Fistula ( Open & Lap), Urgent Gastrointestinal Surgery, Volvulus
Department Affiliation
Director, Colorectal Cancer Treatment Program
Section Chief, Colorectal Surgery
Research Interest
Colorectal Cancer, Inflammatory Bowel Disease
Additional Information

Dr. James Yoo attended Medical School at the Mount Sinai School of Medicine in New York, NY. He completed his General Surgery Residency at the Beth Israel-Deaconess Medical Center, a major Harvard teaching hospital in Boston, MA. During his surgical training he completed a two-year research fellowship at Harvard University and the University of Cincinnati.

Following the completion of his surgical residency he pursued further specialized fellowship training in advanced laparoscopic colorectal techniques at the Weill Cornell Medical College (New York, NY), followed by a fellowship in Colon and Rectal Surgery at the New York-Presbyterian Hospital (Cornell and Columbia campuses). He joined the faculty of the UCLA Department of Surgery as an Assistant Professor in 2006.

Dr. Yoo’s research interests involve understanding the pathologic processes underlying inflammatory bowel disease (Crohn’s disease and ulcerative colitis), cancer of the colon and rectum, as well as the study of new innovative minimally invasive surgical and endoscopic techniques.

Academic/Teaching Appointments

  • Co-Director, UCLA Colorectal Cancer Treatment Program
  • Assistant Professor, Colon and Rectal Surgery, UCLA School of Medicine
Awards & Recognition
  • Southern California Super Doctors 2012
  • Recognized as a Los Angeles Super Doctor 2011 and a Leading Health Professional of the World 2011
  • NIH KO8 Mentored Clinical Scientist Research Career Development Award
  • National Research Service Award (NRSA) Grant [DK T32 0775403] 2000-2002
  • Milton Handler Award [Honors Skill/Compassion in Clinical Medicine]
  • Alpha Omega Alpha - Mount Sinai School of Medicine


  • American Society of Colon and Rectal Surgeons
  • American College of Surgeons
  • Association of Academic Surgeons
  • Yoo J, Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E. Protein Kinase D1 Mediates Synergistic MMP-3 Expression induced by TNF-a and Bradykinin in Human Colonic Myofibroblasts. Biochemical and Biophysical Research Communications. 413(1):30-5, 2011.
  • Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E, Yoo J. TNF-a Potentiates Lysophosphatidic acid-induced COX-2 Expression via PKD in Human Colonic Myofibroblasts. Accepted to Am J Physiol Gastrointest Liver Physiol. 300(4): G637-46, 2011.
  • Cabot JC, Lee SA, Yoo J, Nasar A, Whelan RL, Feingold DL. Long-Term Consequences of Not Closing the Mesenteric Defect After Laparoscopic Right Colectomy. Dis Colon Rectum. 53: 289-292, 2010.
  • Yoo J, Chung C, Slice L, Sinnett-Smith J, Rozengurt E. Protein kinase D mediates synergistic expression of COX-2 induced by TNF-α and bradykinin in human colonic myofibroblasts. Am J Physiol Cell Physiol. 297(6): C1576-87, 2009.
  • Offodile AC, Lee SW, Yoo J, Whelan RL, Moradi D, Baxter R, Arnell TD, Nasar A, Sonoda T, Milsom JW, Feingold DL. Does Prior Abdominal Surgery Influence Conversion Rates and Outcomes of Laparoscopic Right Colectomy in Patients with Neoplasia? Dis Colon Rectum. 51(11):1669-74, 2008.
  • Lee SW, Yoo J , Dujovny N, Sonoda T, Milsom JW. Laparoscopic vs. Hand-Assisted Laparoscopic Sigmoidectomy for Diverticulitis. Dis Colon Rectum . 49: 1-6, 2006.
  • Del Castillo IC, Fedor-Chaiken M, Song JC, Starlinger V, Yoo J , Matlin KS, Matthews JB. Dynamic Regulation of NKCC1 Surface Expression by Protein Kinase C-epsilon in Chloride Secretory Epithelia. Am J Physiol Cell Physio,l 289(5):C1332-42, 2005.
  • Mammen JM, Song JC, Yoo J , Kim PS, Davis HW, Calvo MI, Worrell RT, Matlin KS , Matthews JB. Differential Subcellular Targeting of PKC {epsilon} in Response to Pharmacological or Ischemic Stimuli in Intestinal Epithelia. Am J Physiol Gastrointest Liver Physiol. 288(1): G135-142, 2005.
  • Yoo J, Nichols A, Mammen J, Calvo I, Song JC, Worrell RT, Matlin K, Matthews JB. Bryostatin-1 Enhances Barrier Function in T84 Epithelia through PKC-Dependent Regulation of Tight Junction Proteins. Am J Physiol Cell Physiol. 285(2): C300-309 , 2003.  
  • Yoo J, Nichols A, Song JC, Mammen J, Calvo I, Worrell RT, Cuppoletti J, Matlin K, Matthews JB. Bryostatin-1 Attenuates TNF-Induced Epithelial Barrier Dysfunction: Role of novel PKC isozymes. Am J Physiol Gastrointest Liver Physiol. 284(4): G703-712, 2003.
  • Del Castillo IC, Alvarez JG, Freedman SD, Ollero M, Claros L, Song JC, Yoo J , Matthews JB. Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl(-) secretion. J Surg Res: 110(2): 338-43, 2003.
  • Yoo J , Nichols A, Song JC, Mun EC, Dampens the Secretory Response of Model Intestinal Epithelia Matthews JB. PKC During Ischemia. Surgery: 130(2): 310-318. 2001.
  • Gibson GR, Lesnikoski BA, Yoo J , Mott LA, Cady B, Barth RJ Jr. A Comparison of Ink Directed and Traditional Whole-Cavity Re-excision for Breast Lumpectomy Specimens with Positive Margins. Ann Surg Oncol: 8 (9): 693-704. 2001.
  • Yoo J , Chen H, Kraus T, Hirsch D, Polyak S, George I, Sperber K. Altered Cytokine Production and Accessory Cell Function After HIV-1 Infection. The Journal of Immunology: 157: 1313-1320, 1996.
  • Louie M, Yoo J, Moran T, Mayer L, Sperber K. Impairment of Monocytic Function after Influenza Virus Infection. Clin.Diagn.Lab.Imunol. 2(4): 426-433, 1995.
  • Yoo J , Ellis R, Morgan KG, Hai C. Mechanosensitive modulation of myosin phosphorylation and phosphatidylinositol turnover in smooth muscle. Am J Physiol Cell Physiol. 267(36): C1657-1665, 1994.

Book Chapters

  • Yoo J . Evidence Base for Dissemination of Tumor Cells After Laparoscopic Colorectal Surgery. Milsom J, Nakajima K, Boehm B: Laparoscopic Colorectal Surgery, 2 nd Edition. New York : Springer, 2006.
  • Yoo J, Lotz MM, Matthews JB . Cytokines in Restitution. Cho C-H, Wang J-Y: Gastrointestinal Mucosal Repair and Experimental Therapeutics. Vol. 25, pp14-28, 2002.
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