Research & Clinical Trials

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Our specialists help you prevent and manage health conditions and meet your goals with individualized, expert nutritional care. For help finding clinical nutrition care, call 310-825-7921. To reach the Medical Weight Management Program, please call 310-825-8173.

Research

The UCLA Center for Human Nutrition has research facilities for dietary intervention, controlled feeding studies, body composition studies, strength and aerobic testing, as well as space for phlebotomy, physical examination and sample preparation. The Clinical facilities for research include the Clinical Research Core space, the Daniel S. Abraham Nutrition Research Kitchen and Feeding Center and the Mark Hughes Exercise Performance Laboratory and an Instructional Gym. There are also laboratories in Gene-Nutrient Interaction, Phytochemistry, and Nutritional Biochemistry to support the clinical and basic research of the Division in the UCLA Rehabilition Building on the southwestern end of campus, where it is convenient to both the VA Medical Center and the Ronald Reagan Medical Center. Extensive interdivisional and interdepartmental collaborations exist with urology, dermatology, cardiology, nursing, public health, and psychiatry. These are encouraged as essential for the development of innovative nutrition research.

The UCLA Center for Human Nutrition conducts cutting-edge biomedical and health-related research studies that include both interventional and observational studies. Our clinical studies are sponsored/funded by National Institute of Health (NIH), pharmaceutical companies, and/or non-profit medical institutions/organizations.

If you would like more information on any studies please contact the clinical research staff at (310) 206-8292 or email [email protected].

If you are interested in finding out more information about a particular study, please contact the study personnel.

Current Clinical Trials

Study TypeTitle/PurposePrincipal Investigators
 CURRENT  
Interventional

Nutrition for Precision

The goal of this investigational study is to develop algorithms that predict human response to foods. The main question it aims to answer are:

  • How does varying foods and eating patterns impact one's biological and physiological responses?
  • In what ways can novel dietary assessment measures be used to improve dietary assessments and to prescribe assessments to people in future research with increased precision?
  • Can artificial intelligence and machine learning techniques be combined to prescribe foods and eating patterns to individuals for optimization of their health?

There are 3 Modules participants may take part in:

  • Module 1- A participant's dietary intake and accompanying nutritional status, biological and other measures will be observed over 10 days, as well as physiological responses to a liquid mixed meal tolerance test will be measured.
  • Module 2- Participants will undergo three controlled dietary interventions provided for 14-days each and separated by washout periods of at least 14 days. Physiological responses following a diet-specific meal test will be measured.
  • Module 3- Participants will undergo the same three dietary interventions during the same 14 day periods as Module 2 while being studied in-residence. Physiological responses following a liquid mixed meal tolerance test and a diet-specific meal test will be measured.

Status: Recruitment Ongoing

Zhaoping Li, MD, PhD

For more information contact

Molica Arana

Clinical Study Coordinator

[email protected]

310-206-8292

Interventional

Effect of Metformin ER with Hypocaloric Diet on Weight Loss in Overweight/obese Patients with Increased Waist Circumference

Metformin is a drug used to treat patients with diabetes.  The aim of this study is to examine the effect of Metformin along with a low-calorie diet on obese and/or overweight adults with an increased waist measurement. In addition, the study also aims to look at the effect of the drug vs. placebo on quality of life and physical activity. 

During this study, your participation will last up to 26 weeks (including screen) for a total of 8 clinic visits.  You will undergo a total of 5 blood draws, blood samples taken at screen, baseline and weeks 8, 16 and 24.  You will also be asked to take the study drug or placebo during the duration of this study.  You will be asked to take one capsule a day for two weeks, then increase to 2 capsules a day for the rest of the study at approximately the same time each day.  

Status: Recruitment Ongoing

See Flyer:  English

Zhaoping Li, MD, PhD

For more information contact

Kimberly Ramirez

Clinical Study Coordinator

[email protected]

310-206-8292

Interventional

Effect of Mango Consumption on Skin Health

The purpose of this study is to determine if the daily consumption of one cup of mango compared to 1 oz of pretzel snacks for 12 weeks will 1) enhance antioxidant defense of your skin by assessing the minimal dose of ultraviolet (UV) B light that irritates your skin (reddening-erythema); 2) enhance the ability of your skin to stretch (elasticity), skin moisture (hydration), skin texture, oil secretion (sebum) and reddening (erythema); and 3) measure gene expression of genes involved in oxidative damage (caused by oxygen radicals created by UVB), collagen (structural protein) formation and inflammation (a condition where skin becomes reddened, swollen, hot and painful) in skin cell samples collected by skin tape stripping and blood markers for oxidative stress and inflammation.

Status: Recruitment Ongoing

See Flyer:  English

Zhaoping Li, MD, PhD

For more information contact

Jeraldine Guzman

Clinical Study Coordinator

[email protected]

310-206-8292

Interventional

Effects of Diets on Memory in subjects with Long-COVID Symptoms

The purpose of this study is to determine the effect of daily consumption of two ounces of walnuts compared to habitual diet for 12 weeks in individuals with long-COVID on 1) cognition, fatigue and mood symptoms; 2) clinical parameters such as weight, body composition and inflammatory blood marker, dietary quality and quality of life; and 3) the feasibility of the study design.

Status: Recruitment Ongoing

See Flyer:  English

Zhaoping Li, MD, PhD

For more information contact

Kei Lei

Clinial Study Coordinator

[email protected]

310-206-8292

Interventional

Wearable Sweat Sensor for Non-Invasive Cardiometabolic Monitoring

The purpose of this study is to determine if measurements of cardiometabolic markers, generated by a wearable sweat sensor, correlate to results from blood analyses in individuals with normal weight or overweight/obesity with or without prediabetes during a glucose tolerance test.

Status: Recruitment Ongoing

See Flyer:  English

Zhaoping Li, MD, PhD

For more information contact

Molica Arana

Clinical Study Coordinator

[email protected]

310-206-8292

Interventional

Teaching Kitchen Multisite Trial (TK-MT)

This teaching kitchen intervention study is an 18-month long study with an interactive year-long program that teaches cooking skills, nutrition information, mindfulness and stress reduction techniques, promotes movement, and includes health coaching strategies. Participants must be willing to actively participate in the hands-on classes (may be in-person or virtual), fill out a number of survey questionnaires, complete 4 blood draws, 2 urine samples, along with physical assessments (weight, blood pressure, etc) and 2 stool collections.

Status: Recruitment Ongoing

See Flyer:  English

Zhaoping Li, MD, PhD

For more information contact

Irene Gilbuena

Clinial Study Coordinator

[email protected]

310-206-8292

Interventional

Impact of Anti-Inflammatory Whole-Food Diet in Crohn's Disease and Predicting Response to Therapy

Diet has a strong influence on the composition of the bacteria in our gut and can be important if we want to modify CD symptoms and activity. There is still a great gap in research as to which diets and what diet therapy would be most effective. Previous studies have shown that certain diets were more effective for managing CD symptoms. The aim of the study is to test two different diets and their effect on CD. This is a randomized, single-blind, controlled trial. 

Status: Recruitment Ongoing

 

Zhaoping Li, MD, PhD

For more information contact

Irene Gilbuena

Clinial Study Coordinator

[email protected]

310-206-8292

 

 CLOSED  
Interventional

The IDEA Study:  Intervention with Diet & Exercise for Women Taking Aromatase Inhibitors

Status: Completed

 
Interventional

The Effects of Ellagic acid from Pomegranate Juice vs. Pure Ellagic acid on Healthy Male Subjects

Status: Completed

Zhaoping Li, MD, PhD

 

 

Interventional

The effect of spice consumption on increasing the good bacteria in the human intestine.

Status: Completed

Zhaoping Li, MD, PhD

 

 Interventional

Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Patients

Status: Completed

Zhaoping Li, MD, PhD

 

 Interventional

Effectiveness of changing dietary fat on weight loss

Status: Completed

Zhaoping Li, MD, PhD

 

 

Interventional

Effects of Phytonutrients on Vascular Heath

 Status: Completed

Zhaoping Li, MD, PhD

Susanne Henning, RD, PhD

 

 Interventional

Clinical Trial to Determine the Efficacy of Pomegranate vs. Placebo for Skin Inflammation and Aging

Status: Completed

Zhaoping Li, MD, PhD

Jenny Kim, MD

 

Interventional

The Effect of Dulaglutide on Major Cardiovascular Events in Patients with Type 2 Diabetes: Researching Cardiovascular Events with a Weekly INcretin in Diabetes (REWIND)

Status: Completed

Zhaoping Li, MD, PhD

 

 Interventional

 The Effect of a Healthy Snack on Body Weight and Composition

Status: Completed

Zhaoping Li, MD, PhD
 Interventional

The Effects of Phytoutrients on Vascular Health and Skin in Obese Males

Status: Completed

Zhaoping Li, MD, PhD
Interventional

Effects of Cinnamon Spice on Postprandial Glucose and Insulin in Normal Weight and Obese Individuals with Pre-Diabetes

Status: Completed

Zhaoping Li, MD, PhD
Interventional

Exploratory Study to Determine the Bioavailability of Sugar from Pomegranate Juice vs. Sucrose

Status: Completed

Zhaoping Li, MD, PhD
Interventional

Healthy Avocado Trial (HAT) 

Status: Completed

Zhaoping Li, MD, PhD
Interventional

Nutritional Support to improve outcomes in patients with unresectable pancreatic cancer

Status: Recruitment Closed

Zhaoping Li, MD, PhD
Interventional

Nutritional Supplementation Study: Elderly with Recent Weight Loss

Status: Recruitment Closed

Zhaoping Li, MD, PhD