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Human Papillomavirus (HPV) Studies

There are over 100 types of human papillomavirus (HPV) that infect humans. Some of these types infect the anal and mouth areas. HPV infections in these areas can damage the skin. Rarely, these damaged areas can turn into cancer. There are tests that can find these damaged areas so that they can be treated and removed.

A recent article raises concerns about the risk of the sexually contracted infections in men, due to the large spike in the number of head and neck cancers linked to HPV over the last 20 years within this population, bringing the CARE Center's research on HPV in men to the forefront.

A quadrivalent HPV vaccine, Gardasil, prevents anal HPV infection in HIV infected men. "Quadrivalent" means that the vaccine is directed at four of the HPV types, specifically the types of HPV that have been linked with genital warts and cancer.


The UCLA CARE Center has studies enrolling which examine the HPV vaccine and HPV:


AMC 058
Study of ways to detect anal and genital human papillomavirus (HPV) infection and associated lesions in HIV-positive patients enrolled in another AIDS Malignancy Consortium (AMC) trial. 


AMC 072
Study examining how well the HPV vaccine (Gardasil) works in preventing human papillomavirus (HPV) infection in young (15-25 years old), HIV-positive male patients who have sex with males.  All participants will receive the vaccine.


AMC 076
Study examining two ways to care for patients with abnormal tissue in the anal canal (HGAIN) to try to minimize progression to cancer.  Participants will be randomized to either treatment with a medical device called the Redfield Infrared Coagulator (IRC) or no treatment with careful monitoring.

AMC 084

Study screening HIV infected women for anal cancer precursors


For more information about the UCLA CARE Center's clinical trials and research studies, please contact:
Phone:  (310) 557-9062
Email:  CAREOutreach@mednet.ucla.edu