Four Potential COVID-19 Therapeutics Enter Phase 2/3 Testing in NIH ACTIV-2 Trial
February 12, 2021
Enrollment has begun to test additional investigational drugs in the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program. ACTIV is a public-private partnership program to create a coordinated research strategy that prioritizes and speeds development of promising COVID-19 treatments and vaccines. The new agents entering the randomized, placebo-controlled study are part
Months after fighting coronavirus, some now face heart, lung or neurological problems
February 06, 2021
…“COVID-19 is a disease of extremes. Some people can be asymptomatic and some people can be on a ventilator,” said Dr. Judith Currier, chief of UCLA’s Division of Infectious Diseases in the Department of Medicine. “There’s a full spectrum of outcomes. Most people do recover completely, but there are people who have lingering signs and symptoms.”… Full story on pe.com
February CFAR Seminar: Raphael J. Landovitz, MD, MSc + CFAR Science Spotlight: HIVIDGM
February 03, 2021
When: Wednesday, February 3, 2021 - 9:00 am to 11:00 am PST Meeting ID: 984 9062 5876 Password: CFAR Zoom Link Dial by your location +1 669 900 6833 US (San Jose) +1 213 338 8477 US (Los Angeles) Meeting ID: 984 9062 5876 Password: 363230
If you’re 18 or older and just tested positive for COVID-19, join a clinical study. You’ll be partnered with a team of dedicated experts working towards a breakthrough treatment, and you’ll be compensated for your time. Having COVID-19 doesn’t mean you’re powerless. Together, we can find a treatment.
Empower 24: A Phase 3, Randomized, Active-Controlled, Double-Blind Study
A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of Oral Islatravir Once-Monthly as Preexposure Prophylaxis in Cisgender Men and Transgender Women Who Have Sex With Men, and Are at High Risk for HIV-1 Infection The main purpose of the study is to evaluate the efficacy and safety of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who have sex with men and who are at high risk of HIV-1 infection with a minimum follow-up of 48 weeks and at least 50% of participants have 96 weeks of follow-up after randomization. The primary hypothesis of the study is that the administration of ISL QM as PreP reduces the incidence rate per year of the confirmed HIV-1 infections compared to the background incidence rates.
A5357: A Study of Long-Acting Cabotegravir
A Study of Long-Acting Cabotegravir Plus VRC-HIVMAB075-00-AB (VRC07-523LS) to Maintain Viral Suppression in Adults Living With HIV-1 This study is for people with HIV who have an undetectable viral load. The study will evaluate the safety and effectiveness of a combination of two medications. The first drug is called long-acting cabotegravir (CAB), which will be given orally at first and then as an injection every 4 weeks. The second drug is called VRC-HIVMAB080-00-AB (VRC01LS), which is a monoclonal antibody. A monoclonal antibody targets human proteins rather than attacking the virus directly. The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and antiviral activity of long-acting cabotegravir (CAB LA) plus the broadly neutralizing monoclonal antibody,VRC-HIVMAB075-00-AB (VRC07-523LS), in adults living with HIV-1 with suppressed plasma viremia.
A5379: B-Enhancement of HBV Vaccination
B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B This phase III/IV study will evaluate the response to and safety of the HBV vaccine HEPLISAV-B in two study populations living with HIV: prior HBV vaccine recipients who are deemed non-responders (Group A) and individuals who are naïve to HBV vaccination (Group B). The purpose of this study is to evaluate response to and safety of the HBV vaccine HEPLISAV-B in two study populations living with HIV: prior HBV vaccine recipients who are deemed non-responders and individuals who are naïve to HBV vaccination.
