Antiretroviral therapy (ART) prevents HIV from replicating and spreading but it does not cure HIV. Therapy for HIV must be taken daily for life. This study is attempting to find a way for the immune system to control HIV even after therapy is stopped. This will be achieved by using a vaccine that stimulates the immune system to more strongly recognize the virus. The study is inspired by recent success using a vaccine for the treatment of human papillomavirus (HPV), another chronic virus infection. Although the study team believes a vaccine such as the one being studied here will be helpful for finding a way to allow people with HIV to remain healthy off of therapy, it is not expected that the vaccine will work alone. The study vaccine will hence not cure HIV on its own.
The goals of the study are to see how safe the vaccine products are, how bothersome the side effects are from receiving the vaccine, and to understand the kinds of immune system responses the vaccine creates.
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