• UCLA Health
  • myUCLAhealth
  • School of Medicine
Eye Care

UCLA Stein Eye Institute

Eye Care
  • About Us
    • Message from the Chairman
    • UCLA Stein Eye Institute
    • About Stein and Doheny Affiliation
    • Academic Mission
    • Executive Committee
    • Academic Divisions
    • Academic Centers
    • Philanthropy
    • Mobile Eye Clinic
    • Webinars
    • Job Postings
    • Events
    • News
    • Contact Us
  • Conditions and Treatment
    • Eye Signs and Symptoms
    • Eye Conditions
    • Surgical Treatments
    • Non-Surgical Treatments
  • Eye Research
    • Clinical Trials
    • Clinical Research Center
    • Research Laboratories
    • Research to Prevent Blindness
    • SEI Seminar Series
    • Vision Research Core at UCLA
  • Our Providers
  • Training and Education
    • Educational Activities
    • Training Programs
  • Our Locations
    • UCLA Stein Eye Institute Westwood
    • UCLA Stein Eye Center Santa Monica
    • UCLA Stein Eye Center Calabasas
    • Doheny Eye Center UCLA Pasadena
    • Doheny Eye Center UCLA Arcadia
    • Doheny Eye Center UCLA Orange County
  • UCLA Health
  • myUCLAhealth
  • School of Medicine

UCLA Stein Eye Institute

Eye Research

Eye Research

Eye Research

  • Clinical Trials
    • Cornea and External Eye
    • Eye Infections and Inflammations
    • Glaucoma Clinical Trials
    • Lens and Cataract
    • Macula Retina and Vitreous
    • Neuro-Ophthalmology
    • Pediatrics and Strabismus
  • Clinical Research Center
  • Research Laboratories
    • Advanced Robotic Eye Surgery (ARES) Laboratory
      • Current Lab Members
      • Research Projects
      • Grants and Support
      • News
      • Publications
      • Patents
    • Biology and Genetics of Retinal Disease
      • Research Projects
      • Lab Members
      • Available Positions
      • Grants and Support
      • Selected Publications
    • Cornea Biology
      • Current Lab Members
      • Past Lab Members
      • Publications
      • Available Positions
    • Cornea Genetics
    • Developmental Neurobiology
    • Glaucoma Advanced Imaging Laboratory
      • Lab Members
      • Former Trainees
      • News
      • Publications
      • Education
      • Ongoing Research Projects
      • Grants and Support
      • Links
      • Contact Us
    • Lens Biophysics
    • Molecular Biology of Retinal Ganglion Cells
    • Molecular Neurobiology
    • Ocular Motility
    • Ophthalmic Biophysical Chemistry
    • Ophthalmic Pathology
    • Photoreceptor Biochemistry
    • Photoreceptor - RPE Cell Biology
      • Lab Members
        • Barry L. Burgess
        • Abhishek Chadha, PhD
        • Blake Gilmore
        • Roni Hazim, PhD
        • Nan Hultgren, PhD
        • Antonio Escudero Paniagua, PhD
        • Ankita Umapathy, PhD
        • Stefanie Volland, PhD
        • David S. Williams, PhD
      • Former Trainees
      • Positions Available
      • Research Projects
      • Image and Video Examples
      • Grants and Support
      • Publications
        • Selected Publications
        • All Publications
      • Williams Lab - Latest News
    • Retina Biochemistry & Clinical Disease Modeling Laboratory
      • Lab Members
      • Positions Available
      • Publications
    • Retinal Biochemistry - Inherited Diseases
    • Retinal Cell Biology
    • Retinal Function and Dysfunction
      • About
      • Lab Members
      • Publications
      • Positions Available
    • Retinal Pathophysiology
    • Vision Molecular Biology
    • Visual Physiology
  • Research to Prevent Blindness
  • SEI Seminar Series
  • Vision Research Core at UCLA
    • Biochemistry & Molecular Biology Instrumentation Core
    • Gene & Cell Delivery Core
    • Live Imaging and Functional Evaluation (LIFE) Core:
    • Microscopy and Imaging Analysis Core
      • Research Images and Videos
    • Prototype Construction Core
    • Software Engineering (SE) Core
  • Clinical Trials
  • Clinical Research Center
  • Research Laboratories
  • Research to Prevent Blindness
  • SEI Seminar Series
  • Vision Research Core at UCLA
  • Advanced Robotic Eye Surgery (ARES) Laboratory
  • Biology and Genetics of Retinal Disease
  • Cornea Biology
  • Cornea Genetics
  • Developmental Neurobiology
  • Glaucoma Advanced Imaging Laboratory
  • Lens Biophysics
  • Molecular Biology of Retinal Ganglion Cells
  • Molecular Neurobiology
  • Ocular Motility
  • Ophthalmic Biophysical Chemistry
  • Ophthalmic Pathology
  • Photoreceptor Biochemistry
  • Photoreceptor - RPE Cell Biology
  • Retina Biochemistry & Clinical Disease Modeling Laboratory
  • Retinal Biochemistry - Inherited Diseases
  • Retinal Cell Biology
  • Retinal Function and Dysfunction
  • Retinal Pathophysiology
  • Vision Molecular Biology
  • Visual Physiology
  1. Home
  2. Eye Research
  3. Research Laboratories
  4. Molecular Neurobiology

Molecular Neurobiology

Share this

Contact Information
Phone: (818) 895-9443
Fax: (818) 895-9554
Email: rlee@ucla.edu

Location Address
Sepulveda VA Medical Center
16111 Plummer Street
North Hill, CA 91343

Research Areas

Phosphoprotein and G Protein Interactions in Vision and Blindness

Description

Dr. Lee’s research goal is to understand the biochemical mechanisms that carry out and regulate normal photoreceptor activities and cause photoreceptor cell death in animals and humans affected by retinal degeneration. Currently, she is investigating phosducin, an important regulator of the photoreceptor G protein, by studying how light and pathological conditions change the phosphorylation of phosducin (a reversible chemical reaction that adds/removes phosphate to a protein) and how phosphorylation affects phosducin's interaction with the G protein and other photoreceptor proteins.

Representative Publications

Chen F, Ng P-N, Faull KF, Lee RH. Cone photoreceptor beta, gamma-transduction: Post-translational modification and interaction with phosducin. Invest Ophthalmol Vis Res 2003;44:4622-9.

Marguli A, Dang L, Pulukuri S, Lee R, Sitaramayya A. Presence of phosducin in the nuclei of bovine reitnal cells. Mol Vis 2001;8:477-82.

Chen F, Lee RH. Phosducin and bg-transduction interaction I: Effects of post-translational modifications. Biochem Biophys Res Comm 1997;233:370-4.

Lee RH, Ting TD, Lieberman BS, Tobias DT, Lolley RN, Ho Y-K. Phosducin and transduction interactions: Down regulation by phosducin or retinal cGMP cascade in reconstituted rod outer segments. J Biol Chem 1993; 267:25104-12.

Lee RH, Lieberman BS, Yamane HK, Bok D, Fung BB-K. A third form of the G protein b subunit: Immunochemical identification and localization to core photoreceptors. J Biol Chem 1993;267:24776-81.

Grants

Department of Veterans Affairs Medical Research Service: Phosphoprotein and G Protein Interactions in Vision and Blindness, 10/1/01-9/30/05

Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest
UCLA Health hospitals ranked best hospitals by U.S. News & World Report
  • UCLA Health
  • Find a Doctor
  • School of Medicine
  • School of Nursing
  • UCLA Campus
  • Directory
  • Newsroom
  • Subscribe
  • Patient Stories
  • Giving
  • Careers
  • Volunteer
  • International Services
  • Privacy Practices
  • Nondiscrimination
  • Billing
  • Health Plans
  • Emergency
  • Report Broken Links
  • Terms of Use
  • 1-310-825-2631
  • Maps & Directions
  • Contact Us
  • Your Feedback
  • Report Misconduct
  • Get Social
  • Sitemap
Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest

Sign in to myUCLAhealth