Clinical Trials

Research and Clinical Trials

Helpful Links

Information for Participants (UCLA OHRPP)
Understanding Clinical Trials (ClinicalTrials.gov)
UCLA Cancer Trials (UCLA JCCC)
Link to Non-Cancer Trials at UCLA

UCLA conducts research for a wide range of medical disorders and offers patients opportunities to participate in research and clinical trials.

Visit our Office of Clinical Trials website for more information about clinical trials.

Below are some featured trials at UCLA. Click here for a PDF of these trials. You may also visit the links to the right for additional trials from our clinical departments.


UCLA Aftercare Research Program

The Aftercare Research Program at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA will provide free treatment and assessment for participants in a clinical research study that is designed to improve the understanding of psychotic disorders and to develop more effective treatments. An initial diagnostic interview will determine a patient’s eligibility. The study will include individual case management, group therapy and the antipsychotic medication risperidone. Family members of patients will be invited to join family psychoeducational meetings. An initial period on risperidone is a requirement of this study, so a change of medication may be needed.
Info: (310) 206-3142 or email aftercare@mednet.ucla.edu, luana@ucla.edu or www.semel.ucla.edu/aftercare

Alzheimer’s Disease Study

Does Alzheimer’s disease run in your family? Are you worried about memory loss in the future? The UCLA Mary S. Easton Center’s clinical trial program is conducting a study aimed at individuals between the ages of 65 and 85 with a first-degree relative with Alzheimer’s disease and an increased likelihood of developing memory loss and changes in the brain associated with the disease.
Info: (844) A4STUDY (844-247-8839) or (310) 794-6191 A4Study.org

Family-focused Treatment for Childhood OCD

Does your child have Obsessive Compulsive Disorder (OCD)? Does he/she have recurring thoughts that make no sense, but makes him/ her feel bad; wash excessively or have fear of touching “contaminated” things; check and double-check more than necessary and have to do things over and over again? A UCLA research study is looking for kids and teens between 8 and 17 years of age with OCD to study family involvement in non-medication cognitive behavioral therapy (CBT). Eligible participants will receive 14 weeks of free treatment.
Info: (310) 206-1350

Child Anxiety Study

This UCLA research study conducted by Susanna Chang, PhD, is looking for children ages 8 to 17 with social anxiety, generalized anxiety and separation anxiety to participate along with their parents in an investigation of the usefulness of a novel computer-based attention training treatment for childhood anxiety. Participation involves EEG recordings and eight weeks of a non-medication attention-training treatment for children. Parents of eligible study youth are also asked to participate in similar attention-training treatment to study how their participation may improve their child’s anxiety.
Info: (310) 825-2064

Child Obsessive Compulsive Disorder Study

This UCLA research study conducted by Susanna Chang, PhD, is looking for children ages 8 to 17 to participate in a study to investigate the usefulness of a novel computerbased attention-training treatment for childhood OCD. Participation involves EEG recordings and four weeks of a non-medication attention-training treatment.
Info: (310) 825-2064

Cognitive Physiological Correlates of Anxiety in Youth

This study, conducted by Michelle Rozenman, PhD, and John Piacentini, PhD, at the UCLA Semel Institute for Neuroscience and Human Behavior, is looking for healthy children between the ages of 9 and 17 years, who are living with their parents or legal guardian, for a psychological evaluation about how youths perceive and think about the world. Participants will undergo two computer tasks and two problem solving tasks and have their heart rate and breathing monitored. The study takes approximately three hours and requires one visit to UCLA. Please note that the study does not provide transportation to/from or parking at UCLA.
Info: (310) 794-2215

Child Attention & Real-world Emotion Study

Does your child have frequent worries or fears? UCLA is recruiting children between the ages of 6 and 9 for a study about how attention may be related to the ability to manage emotions like anxiety or fear. The research study involves questionnaires and interviews about you and your child’s mood and behaviors, computer tasks to see how kids process emotional information (like facial expressions), and recording of your child’s brain waves while they view emotional information. The study involves two weekends of short (five to 10 minute) phone interviews about your child’s activities and emotions, as well as short (45 second) audio recordings of your child’s emotional expressions. The study involves two visits to our research laboratory (for three hours total) and two weekends of phone calls. We will also ask parents to complete a few questionnaires at six and 12 months following the last laboratory visit. Participants will receive compensation for their time and transportation costs. Interested families may be provided with clinical referrals. There are no medical risks associated with this study.
Info: (310) 835-2701

Mild Cognitive Impairment

The UCLA Mary S. Easton Center’s clinical trial program is conducting a study of individuals between the ages of 50 and 85 who have mild cognitive impairment. The trial involves 28 months of an investigational medication or placebo to test the medication’s safety and tolerability in the treatment of subjects with amnestic mild cognitive impairment due to Alzheimer’s disease. Qualified participants will not be charged for any study procedures. Participants may receive compensation for time and travel.
Info: (310) 794-6191

Depression in Older Adults

UCLA is conducting a 12-month research study for those who are suffering from depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy, or loss of interest and pleasure in activities, to compare the effects of levomilnacipran (FETZIMA) to placebo for treating geriatric depression. If you are 60 years of age or older, you may qualify. A complete psychiatric evaluation, physical exam and one MRI scan are provided as a part of the study. All participants will be given either levomilnacipran (FETZIMA) or a placebo (an inactive substance). Participants will be compensated up to $200 and parking will be reimbursed.
Info: (310) 794-9523 or (310) 794-4619

Geriatric Depression

The UCLA Geriatric Psychiatry Program is conducting an early-phase, 12-week research study to compare the effects of two FDA-approved medications: Vilazodone and Paroxetine for the treatment of geriatric depression. This study is for those who are suffering from depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy, or loss of interest and pleasure in activities. All participants will be given a study drug, either Vilazodone or Paroxetine. A complete psychiatric evaluation will be provided. Subjects will not be charged for participation and will be compensated. Participants must be 60 years or older and experiencing symptoms of depression.
Info: (310) 983-3375 or (310) 794-4619

Treating Fibroids with Radiofrequency Energy

Researchers at UCLA are conducting a study of a new FDA-approved minimally invasive outpatient fibroid treatment called Acessa. If you have fibroids that cause heavy bleeding, pelvic pressure or any other significant symptoms, you may be eligible to participate. You will receive gift cards up to $180 for participation.
Info: (310)794-9652 or uclaobgynresearch@mednet.ucla.edu

Late-life Depression

For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy, or loss of interest and pleasure in activities UCLA is conducting a 12-month research study using an experimental combination of two drugs and a placebo (an inactive substance). If you are 60 years of age or older, not currently receiving any psychiatric treatment with effective medications, you may qualify. Medical and psychiatric evaluations and limited physical exams are provided as a part of the study. Participants will undergo a PET scan and an MRI scan. Evaluations and study drug are provided at no charge.
Info: (310) 983-3375 or (310) 794-4619

Memory Enhancement Training or Yoga for Older Adults

For those who are suffering from memory loss, concentration difficulties, or lack of energy, UCLA is conducting a six-month research study comparing a 60-minute weekly memory enhancement training course to yoga meditation. If you are 55 years of age or older and not currently receiving any psychiatric treatment, you may qualify. Medical and psychiatric evaluations and limited physical exams are provided as a part of the study. Participants will undergo two functional magnetic resonance imaging (fMRI) scans. A complete psychiatric evaluation will be provided. Participants will be compensated.
Info: (310) 794-9523 or (310) 794-4619

Memory and Exercise Training (MET) Study

This project is designed to study the relationship of simultaneous exercise and memory training. Volunteers 60 to 75 years of age, in good health and living independently are encouraged to participate. The study will involve memory training, memory testing and physical exercise over the course of 14 weeks. Subjects will be compensated for participation and receive clinically relevant results of assessments.
Info: (310) 825-0545

Obstructive Sleep Apnea (OSA) Research Study

UCLA researchers are seeking patients between the ages of 21 to 75 who have recently been diagnosed with obstructive sleep apnea and have not yet started treatment to participate in a study to see how changes in brain function and structure relate to autonomic impairments. The study is also seeking healthy control participants who are in good health, and non-smokers without sleep disorders. People interested in participating will go through a screening process and those determined eligible will be enrolled in the study. Enrolled participants will be invited to do one or more of the following: MRI scanning; physiological testing; simple, daily home physiological testing, and brief questionnaires using a smart phone. Study participants will not be charged for any study procedure and will be compensated for participation.
Info: (323) 362-8818 or projectdirector@osabrainresearch.org

Pomegranate Juice Study

The UCLA Longevity Center is studying the effect of pomegranate juice on memory. Volunteers between the ages of 50 and 75 are needed. The study lasts one year and includes five visits to UCLA and $300 compensation for participation.
Info: (310) 825-0545

Stroke / EDAS Revascularization for Intracranial Arterial Stenosis

Patients suffering strokes or transient ischemic attacks (TIA or mini-strokes) due to narrowing of the arteries of the brain may benefit from interventions to create new paths for the flow of blood to the brain. Medical management alone has been associated with very high risk of recurrent stroke and death. EDAS surgery is a form of minimally invasive management that can induce new vessel formation to bring additional blood flow to the brain preventing stroke.
Info: (310) 825-5154

Tai-Chi or Health Education and Wellness for Older Adults

For those who are suffering from depressive symptoms, lack of energy, and on stable medications for depression, UCLA is conducting a six-month research study involving 12 weekly 60-minute sessions of either a health and education wellness class or a Tai-Chi class. Participants will undergo two functional magnetic resonance imaging (fMRI) scans. A complete psychiatric evaluation will be provided. If you are 60 years of age or older, you may qualify. Participants will be compensated.
Info: (310) 794-4619 or (310) 794-9523

Vulvodynia Research

UCLA researchers are seeking women ages 18 to 55 to help understand brain activity changes associated with a chronic pain condition called vulvodynia. Women who have been diagnosed with vulvodynia or vestibulodynia, or those with chronic pain around the opening of the vagina, may be eligible to participate. Participation includes a pelvic exam, sensitivity testing and MRI scans. Volunteers can earn up to $130 for participating.
Info: (310) 825-5255 or uclaobgynresearch@mednet.ucla.edu

Central Autonomic Nervous System Regulation in Heart Failure

Research study seeks women and men 40 to 65 years old who have a diagnosis of heart failure to participate in a brain magnetic resonance imaging (MRI) study investigating relationships between the brain and symptoms of heart failure. Participation involves a single three-hour visit at UCLA to undergo a non contrast brain MRI and complete questionnaires. Study eligibility will be determined during a brief telephone screening prior to participation. Eligible participants will be compensated up to $200 plus parking.
Info: (424) 256-5269 or (310) 794-4429; brainstudies2012@gmail.com

Brain Axonal Injury in Obstructive Sleep Apnea

This research study seeks women and men 30 to 60 years old with untreated, moderate-to-severe, recently diagnosed obstructive sleep apnea (OSA) based on a sleep study to participate in a brain magnetic resonance imaging (MRI) study examining possible relationships between OSA and structural changes in the brain. Participation involves a single three-hour visit at UCLA to undergo a non-contrast brain MRI and complete questionnaires. Study eligibility will be determined during a brief telephone screening prior to participation. Eligible participants will be compensated up to $200 plus parking.
Info: (424) 256-5269; brainstudies2012@gmail.com

Menstrual Irregularities and PCOS Study

UCLA researchers are seeking women with and without Polycystic Ovary Syndrome (PCOS). To be eligible, women must be Caucasian and non-Hispanic, between the ages of 18 and 35, have body mass index (BMI) between 18.5 and 25, and have not used hormones (i.e., birth control pills or a Mirena IUD) for the past three months. Participants will receive extensive free medical testing including blood hormone measurements, diabetes screening, ovarian and fat assessment. A small amount of fat will be removed from the abdomen and blood will be drawn for research purposes. Only women with PCOS will take an oral pill that contains either the drug Flutamide or a placebo (sugar pill) for six complete 28-day cycles. The free medical testing will be repeated at the end of the study. Women without PCOS may earn up to $300 and women with PCOS may earn up to $840.
Info: (310) 825-0580; or uclaobgynresearch@mednet.ucla.edu

Effects of E-cigarettes on Sympathetic Nerve Activity

Seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on sympathetic nerve activity (nerves that carry adrenaline) and blood levels of anti-oxidants . Must be a NON-SMOKER or you must be an E-cigarette user. The study will involve either a two-hour visit, or three two-hour visits (depending on which group you're in) to the UCLA Clinical and Translational Research Center. Monetary compensation provided.
Contact Kacey Peters at (310) 825-3510 or kpeters@mednet.ucla.edu to learn more about the study.


For more information about Clinical Trials offered to cancer patients, visit:
www.cancer.ucla.edu/clinical-trials or call UCLA jonsson Comprehensive Cancer Center (JCCC) Clinical Trials Hotline at (888) 798-0719.