Arnold I. Chin, MD, PhD

Dr. Chin's clinical expertise includes urologic oncology and renal transplantation, performing open, laparoscopic, and robotic-assisted surgeries for bladder, kidney, and prostate cancer patients.

His laboratory studies the tumor microenvironment in prostate and bladder cancer using a combination of animal models, human reconstitution systems, and primary tumor and hematopoietic cells. They are interested in several aspects including the following:

1. Molecular mechanisms in programming tumor-infiltrating lymphocytes. The nature and composition of immune cells in cancer have been linked with tumor grade and overall survival. However, the determinants that lead to immune infiltrating cells in cancer is unclear. Dr. Chin's lab is studying the endogenous signals, innate immune, and adaptive immune pathways that program the composition of the tumor immune microenvironment, and how these will influence tumor proliferation, invasion, and metastasis. He and his team are also interested in how they can reprogram the immune components of the tumor microenvironment to shape tumorigenicity.
2. Mechanisms controlling development and differentiation of cancer stem cells. Cancer initiating cells share similar features to stem cells with their ability for self-renewal and pluripotency. These cell populations may explain the recurrent nature and drug resistance of cancer. Dr. Chin's laboratory is studying the cell intrinsic signals as well as the cell extrinsic influences from immune and stromal cells of the cancer stem cell in their differentiation, ability to undergo epithelial-to-mesenchymal transition, and development of an invasive phenotype.

His studies will provide fundamental understanding of the tumor microenvironment, as well as develop therapeutic targets, novel immune-based platforms, and stem cell based therapies against cancer.

Link to Dr. Chin's PubMed publications >

• "The Big Reason I Became a Scientist Is All the Unknowns."  - YouTube
• Robotic Radical Prostatectomy - YouTube
• Robotic Radical Cystectomy - YouTube
• Robotic Ureteral Reimplant - YouTube
• Robotic Partial Nephrectomy - YouTube
• Robotic Ureterolysis and Omental Wrap - YouTube
• Robotic Retroperitoneal Lymph Node Dissection for Upper Tract Urothelial Carcinoma - YouTube

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• Super Doctors® Southern California 2022 - 2024
• Super Doctors® Southern California Rising Stars 2018
• STOP Cancer Research Career Development Award 2010
• American Association of Cancer Research Career Development Award for Translational Cancer Research 2010

• stemcell.ucla.edu/member/chin
• uclahealth.org/urology
• uclahealth.org/robotic-surgery