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Clinical Research

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  2. Clinical Research

Clinical Research

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Search Results 1-10 of 48 clinical trials found.

1 2 3 4 5 Next

Multicenter Study Assessing the Efficacy and Safety of DE-126 Ophthalmic Solution 0.002% Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Reduction of elevated pressure in the eye (Intraocular pressure, or 'IOP') with eye drop medications has been shown to be effective in delaying or preventing the progression of glaucoma, and it is the only proven method for reducing the risk of glaucomatous visual field loss. This study is being conducted to determine how well DE-126 ophthalmic solution works (efficacy) in safely lowering IOP when dosed as topical eyedrops. This study will evaluate the safety and efficacy of DE-126, ophthalmic solution in subjects with Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT). The IOP will be measured at 3 different times throughout the day, over 4 total visits during a 3-month treatment period (with up to 4 extra weeks observation if the patient must stop taking current eye drops to lower IOP). Safety assessments will be done throughout the study, including ocular signs and symptoms, and vital ...

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Status: Open/Actively Recruiting
Primary Purpose: Treatment
Gender: All
Contact: Connie Zhen
Investigator: Alex Huang

Amyloid dye staining on trabecular meshwork tissue to detect protein aggregation in glaucoma

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Status: Open/Actively Recruiting
Age Group: Adult
Contact: Margarita Gonzalez
Investigator: Anne Coleman

A Study of NGM621 in Participants With Geographic Atrophy

This is a multi-center evaluation of NGM621 in a randomized, double-masked, sham-controlled study in participants with Geographic Atrophy secondary to Age-related Macular Degeneration.

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Status: Open/Actively Recruiting
Primary Purpose: Treatment
Gender: All
Contact: Alisa Molina
Investigator: Steven Schwartz

Study to Gather Information on Safety and Use of High Dose Aflibercept Injection Into the Eye in Patients With an Age Related Eye Disorder That Causes Blurred Vision or a Blind Spot Due to Abnormal Blood Vessels That Leak Fluid Into the Light Sensitive Lining Inside the Eye

In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.

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Status: Open/Actively Recruiting
Primary Purpose: Treatment
Gender: All
Contact: Mary Crowley
Investigator: Jean Hubschman

PRESERFLO® MicroShunt Extension Study

This prospective, concurrent controlled, open-label, multicenter study is designed to collect additional safety data through 5 years of follow-up for subjects randomized to either the treatment arm (PRESERFLO® MicroShunt with MMC) or the control arm (Trabeculectomy with MMC) of the INN-005 clinical study.

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Status: Open/Actively Recruiting
Gender: All
Age Group: Adult
Contact: Gerard Aquino
Investigator: Joseph Caprioli

Evaluation of the Rotational Stability of the Tecnis Toric II IOL

This is a prospective, multicenter, single-arm, open-label clinical study of the commercially available TECNIS Toric II IOL. The study will be conducted in up to 192 subjects needing unilateral or bilateral cataract surgery in up to 8 sites in United States (US). The subjects will be followed for up to 3-months postoperatively.

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Status: Open/Actively Recruiting
Phase: Phase IV
Primary Purpose: Treatment
Gender: All
Age Group: Adult
Contact: Omar Leyva
Investigator: Kevin Miller

A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm

Study GR41675 is a Multicenter, Randomized Study in Participants with Diabetic Retinopathy (DR) Without Center-Involved Diabetic Macular Edema (CI-DME) to Evaluate the Efficacy, Safety of the Port Delivery System with Ranibizumab (PDS) Relative to the Comparator Arm

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Status: Open/Actively Recruiting
Primary Purpose: Treatment
Gender: All
Contact: Mary Crowley
Investigator: Steven Schwartz

Predicting Eye Disease in Childhood Arthritis- Uveitis Study (PEDIA-U)

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Status: Open/Actively Recruiting
Contact: Omar Leyva
Investigator: Gary Holland

A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)

The objectives of this study are to evaluate the safety and efficacy of Zimura intravitreal administration in patients with geographic atrophy secondary to age-related macular degeneration (AMD)

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Status: Open/Actively Recruiting
Primary Purpose: Treatment
Gender: All
Contact: Daniel Cordova
Investigator: Steven Schwartz

Study of Ocular Disease using Hyper Parallel Optical Coherence Tomography

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Status: Open/Actively Recruiting
Age Group: Adult
Contact: Ellen Pascual
Investigator: Edmund Tsui

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