UCLA conducts research for a wide range of medical disorders and offers patients opportunities to participate in research and clinical trials.
Visit our Office of Clinical Trials website for more information about clinical trials.
Below are some featured trials at UCLA. Click here for a PDF of these trials. You may also visit the links to the right for additional trials from our clinical departments.
Information for Participants (UCLA OHRPP)
Understanding Clinical Trials (ClinicalTrials.gov)
UCLA Cancer Trials (UCLA JCCC)
Link to Non-Cancer Trials at UCLA
This phase II-a clinical trial will investigate whether the oral investigational drug SUVN-502 can enhance the cognitive effect of two FDA medications (donepezil and memantine) approved for use in patients with dementia. Individuals ages 50 to 85 with a diagnosis of moderate dementia who are taking the maximum dosages of donepezil and memantine may be eligible to participate. Patients will have a 60 percent chance of receiving the active study drug versus placebo (inactive substance). The study will last 26 weeks. Info: 310-794-6191 or firstname.lastname@example.org
The NEAT study is a phase II-b clinical trial focusing on nicotinamide, a soluble form of vitamin B3. This one-year study will investigate the safety and tolerability of daily high-dose oral nicotinamide, and assess whether nicotinamide is able to reduce levels of phosphorylated tau found in spinal fluid. It will also assess whether nicotinamide is effective in reducing the rate of cognitive and functional decline. This study seeks individuals ages 50 to 85 with a diagnosis of mild cognitive impairment or mild dementia due to Alzheimer’s disease. Participants will have a 50 percent chance of receiving the study drug versus a placebo (inactive substance). Info: 310-794-6191 or email@example.com
ADNI3 is the fourth wave of a North American multicenter observational study launched in 2004. The primary goal of this study is to discover, optimize, standardize and validate clinical biomarkers used in Alzheimer’s disease research and clinical trials. This study seeks participants between 55 and 90 years old who are willing and able to undergo yearly test procedures, including cognitive tests, questionnaires, brain imaging, blood draws and spinal taps. Eligible individuals may have normal cognition with no memory concerns, or have memory concerns and diagnosis of mild cognitive impairment or dementia due to Alzheimer’s disease. Participants will be evaluated on a yearly basis, for two to four years. Info: 310-794-6191 or firstname.lastname@example.org
UCLA is conducting a 12-week research study called “Comparison of Levomilnacipran to Placebo in Geriatric Depression” for adults 60 years of age or older who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy, or loss of interest and pleasure in activities. The study is designed to determine the efficacy, safety and tolerability of levomilnacipran (FETZIMA) in treating geriatric depression. A complete psychiatric evaluation, physical exam and two MRI scans are provided. Eligible participants will be compensated up to $350 and parking will be reimbursed. Info: 310-267-5264 or 310-794-9523
If you are 60 years or older, depressed, or taking an antidepressant but not feeling better, you may be eligible to participate in the OPTIMUM research study. Eligible participants will be given randomized medication options: Step 1: (for 10 weeks) adding aripiprazole or bupropion to current antidepressant; or switch to bupropion or Step 2: (for 10 weeks) adding lithium to current antidepressant; or switch to nortriptyline. The study team will assess your side effects and mood for up to 12 months. Study psychiatrists will provide medication recommendations to your primary care physician. Info: 310-206-5240.
UCLA is seeking participants 60 years of age or older who are on stable medications for depression and are suffering from depressive symptoms and lack of energy to participate in a six-month research study. The trial involves 12 weekly 60-minute sessions of either a health and education class or a tai chi class, an exercise technique that focuses on mind-body wellness. Participants will undergo two functional MRI scans and a complete psychiatric evaluation. Participants will be compensated. Info: 310-794-4619 or 310-794-9523
UCLA is seeking women over the age of 50 suffering from memory concerns to participate in a study of yoga and memory training. Eligible participants must have either high blood pressure, high cholesterol, heart problems or diabetes. The year-long study will include 12 weekly 60-minute sessions of yoga or memory training. Participants will undergo two functional magnetic resonance imaging (fMRI) scans. A complete psychiatric evaluation will be provided. Participants will be compensated up to $250 and reimbursed for parking. Info: 310-825-2065.
Led by principal investigator Emeran Mayer, MD, PhD, the UCLA Oppenheimer Center for Neurobiology of Stress and Resilience is conducting a brain imaging research study regarding ulcerative colitis (UC). Participants must be between 18 and 60 years of age, not pregnant or breastfeeding, diagnosed with UC, right-handed and in otherwise good health without significant neurological or psychological history. Participants will receive digital images of their brains and earn up to $95. Info: 310-206-1758 or uclacns.org.
UCLA is conducting a six-week research study that focuses on wellness after breast cancer. Mindfulness meditation and survivorship education classes will be offered to compare the effectiveness of the two classes. Participants must attend three in-person appointments throughout the duration of the study. This study seeks women diagnosed with breast cancer at age 50 or younger who were diagnosed within the last five years. Info: 310-825-2520 or ucla.in/2nPqFAV.
This randomized clinical trial will investigate whether cinnamon spice can affect the glucose and insulin levels. Individuals ages 20 to 50 who are generally in good health and typically consume a low fiber/polyphenol diet (beige diet) may be eligible to participate if they are in their either normal weight range or overweight and pre-diabetic. Participants will have a 50 percent chance of having oatmeal with or without cinnamon spice. The study will last 4 weeks. Eligible participants will be compensated and a daily parking pass will be provided. Info: 310-206-8292 or ZEzzatZadeh@mednet.ucla.edu. Visit the Clinical Nutrition website for more details.
This randomized controlled study will evaluate the effect of polyphenol consumption, specifically those in pomegranate juice, on established parameters of cardiovascular health, skin inflammation and aging. This study will compare the effects of consuming 8 oz. pomegranate juice or 8 oz. placebo juice. We are seeking healthy, non-smoking males aged 18-65, with a BMI between 30 to 45. The study will last 12.5 weeks (5 clinic visits total). Eligible participants will be compensated up to $450 and a daily parking pass will be provided. Info: 310-206-8292 or DBenNissan@mednet.ucla.edu. Visit the Clinical Nutrition website for more details.
The Healthy Avocado Trial, or “HAT,” is a multi-site nutrition study looking at the effect of avocado consumption on abdominal fat, waist circumference, cholesterol levels, and vascular health. The UCLA Center for Human Nutrition is seeking male and female participants 25 years of age or older with increased waist circumference (≥35 inches for women, ≥40 inches for men). Participants will either be provided with one avocado per day to eat with their usual diet for 6 months or will be asked to maintain their usual diet (minus avocados) for the same duration. The study will last 6 months with 10 clinic visits. Eligible participants will be compensated and a daily parking pass will be provided. Info: 310-206-8292 or DOMCHN@mednet.ucla.edu. Visit the HAT website for more details.
UCLA Center for Human Nutrition is seeking healthy volunteers 30 to 75 years of age and overweight (BMI 27.0-35.0 kg/m2) to participate in a weight-loss research study. Participants will either consume mixed nuts or an equally caloric amount of pretzels daily for 24 weeks. They will also be asked to follow a hypocaloric diet for the first 12 weeks, followed by an isocaloric diet for the second 12 weeks. The study will last 6 months with 9 clinic visits total. Eligible participants will be compensated and a daily parking pass will be provided. Info: 310-206-8292 or MVerdel@mednet.ucla.edu . Visit the Clinical Nutrition website for more details.
UCLA researchers are seeking women 18 years of age or older with untreated fibroids who wish to receive treatment and avoid hysterectomy to compare approved uterine-sparing fibroid treatments. Menstruating women who have symptomatic uterine fibroids and desire uterine conservation may be eligible to participate. Eligible women may receive treatment through the TRUST (Treatment Results of Uterine Sparing Technologies) USA study.Info: www.ClinicalTrials.gov (search identifier: NCT02163525)
Center for Neurobiology of Stress and Resilience is conducting a mind/body research study for those suffering from IBS symptoms (abdominal pain or discomfort) and altered bowel habits (constipation or diarrhea). Participants must be 18 to 60 years of age, right handed, not pregnant or breastfeeding, and have no significant neurological or psychological medical history. Participants must undergo an MRI, blood and stool sample and digital brain imaging. Female participants may earn up to $620 for completing all five visits over 12 months at 3-month intervals. Male participants may earn up to $150 for a screening visit, MRI and one stool and blood sample.Info: 310-206-1758
For information on other digestive diseases clinical trials and studies, please visit: uclahealth.org/gastro/clinical-trials.
UCLA researchers are seeking women ages 18 to 55 to help understand brain activity changes associated with a chronic-pain condition called vulvodynia. Women who have been diagnosed with vulvodynia or vestibulodynia, or those with chronic pain around the opening of the vagina with or without intercourse, may be eligible to participate. Participation includes a pelvic exam, sensitivity testing, one small blood sample and one MRI scan. Volunteers can earn up to $210 for participating. Info: 310-825-5255 or email@example.com
UCLA is seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on blood vessel function. The study will involve 4, 2 hour visits. Must be an E-Cigarette user, or a non-smoker. Monetary compensation provided. Info: 310-825-3510 or firstname.lastname@example.org
UCLA is seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on blood vessel function. The study will involve 2, 2 hour visits. Must smoke tobacco cigarettes. Monetary compensation provided. Info: 310-825-3510 or email@example.com
UCLA is seeking adults between the ages of 18 and 65 with a history of vestibular migraine (VM) – a recently recognized type of migraine headache that causes attacks of vertigo and dizziness – to participate in a research study. Participants will undergo an observation phase and a treatment phase. While in the study, participants will need to document how often they get VM and track five of their last episodes in a diary. The study includes up to three visits and $50 in compensation per visit. Info: 310-206-8511