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Cognitive Intervention to Improve Working Memory

About

Brief Summary

Adolescents with single ventricle heart disease (SVHD) (10 males and 10 females) with mild to moderate cognitive impairment will participate in a total of 25 computer-based working memory training sessions, each 30-40 minutes (5 days a week for 5 weeks) supervised by a trained coach. Primary objective is to evaluate the impact of the Cogmed intervention on working memory scores and the secondary objective to assess brain tissue changes with magnetic resonance imaging (MRI) using diffusion tensor imaging (DTI) techniques, measures of mean diffusivity pre- and post-intervention.

Primary Purpose
Treatment
Study Type
Interventional
Phase
N/A

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
14 Years
Maximum Age
18 Years

Inclusion Criteria:

  • be 14-18 years old
  • have SVHD
  • undergone Fontan completion
  • understands English
  • able to read computer screen
  • have phone access
  • MoCA score of 25 to 10

Exclusion Criteria:

  • pregnancy
  • claustrophobia
  • presence of loose metal
  • prior head injury or stroke
  • clinical diagnosis of depression
  • previous cardiac arrest and ECMO use
  • currently listed for heart transplant
  • known genetic syndrome
  • severe developmental delay
  • born less than 35 weeks gestation

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Study Stats
Protocol No.
20-000819
Category
School of Nursing
Principal Investigator
Nancy Pike
Contact
Nancy Pike
Location
  • UCLA Westwood
For Providers
NCT No.
NCT03687008
For detailed technical eligibility, visit ClinicalTrials.gov.