Cognitive Intervention to Improve Working Memory

About

Brief Summary

Adolescents with single ventricle heart disease (SVHD) (10 males and 10 females) with mild to moderate cognitive impairment will participate in a total of 25 computer-based working memory training sessions, each 30-40 minutes (5 days a week for 5 weeks) supervised by a trained coach. Primary objective is to evaluate the impact of the Cogmed intervention on working memory scores and the secondary objective to assess brain tissue changes with magnetic resonance imaging (MRI) using diffusion tensor imaging (DTI) techniques, measures of mean diffusivity pre- and post-intervention.

Primary Purpose

Treatment

Study Type

Interventional

Phase

N/A

Eligibility

Gender

All

Healthy Volunteers

Minimum Age

14 Years

Maximum Age

18 Years

Inclusion Criteria:

be 14-18 years old
have SVHD
undergone Fontan completion
understands English
able to read computer screen
have phone access
MoCA score of 25 to 10

Exclusion Criteria:

pregnancy
claustrophobia
presence of loose metal
prior head injury or stroke
clinical diagnosis of depression
previous cardiac arrest and ECMO use
currently listed for heart transplant
known genetic syndrome
severe developmental delay
born less than 35 weeks gestation

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