Open Actively Recruiting

Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

About

Brief Summary

Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.

Study Type
Observational

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
18 Years
Maximum Age
N/A

Inclusion Criteria:

  • Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
  • ICU stay longer than 24 hours

Exclusion Criteria:

  • Patients with muscular or mitochondrial diseases affecting muscle quality or mass
  • Preexisting paralysis
  • Absence of lower limbs
  • Ongoing discussions about goals of care
  • Transfers from a skilled nursing facility
  • Children under the age of 18

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Study Stats
Protocol No.
20-002271
Category
Anesthesiology & Perioperative Medicine
Principal Investigator
CECILIA CANALES
Contact
Jennifer Scovotti
Location
  • UCLA Westwood
For Providers
NCT No.
NCT04717869
For detailed technical eligibility, visit ClinicalTrials.gov.