Open Actively Recruiting

Norepinephrine vs Phenylephrine During General Anesthesia

About

Brief Summary

50 million patients undergo surgery each year in the United States. Postoperative mortality is considered the third leading cause of death worldwide. Hypotension during surgery have been linked to increased postoperative morbidity and mortality. Episodes of hypotension during surgery are associated with an increased risk of acute kidney injury, stroke, cardiac events and death. Treating or preventing hypotension during general anesthesia and major surgery was found to improve outcomes. At this time, it is unclear what is the best vasopressor to maintain blood pressure during surgery under general anesthesia. With this pilot pragmatic trial, the investigators will explore the impact of norepinephrine (NE) or phenylephrine (PE) on post-operative events in patients undergoing major surgery with general anesthesia and needing vasopressors infusion to maintain their systemic arterial pressure.

Primary Purpose
Supportive Care
Study Type
Interventional
Phase
Phase 4

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
18 Years
Maximum Age
99 Years

Inclusion Criteria:

  • age 18 Years and older
  • Surgery under general anesthesia and requiring infusion of vasopressors to maintain the mean arterial pressure.
  • Surgery duration>2 hours

Exclusion Criteria:

  • Cardiac surgery
  • Patients on ECMO
  • Organ transplantation
  • Outpatient (come-and-go surgery)
  • Obstetric procedures
  • Patient already receiving NE or PE before induction of anesthesia
  • Patients transferred immediately (i.e. within 24 hours) after surgery to another hospital.
  • Patients with severe trauma

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Study Stats
Protocol No.
21-000121
Category
Anesthesiology & Perioperative Medicine
Contact
CLAUDIA BUENO
Location
  • UCLA Westwood
For Providers
NCT No.
NCT04789330
For detailed technical eligibility, visit ClinicalTrials.gov.