Open Actively Recruiting

Optimizing Outcomes of Treatment-Resistant Depression in Older Adults

About

Brief Summary

The purpose of this research study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD).

Primary Purpose
Treatment
Study Type
Interventional
Phase
Phase 4

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
60 Years
Maximum Age
N/A

Inclusion Criteria:

  • Men and women aged 60 and older
  • Current Major Depressive Disorder (MDD)
  • Failure to respond adequately to two or more antidepressant treatment trials of recommended dose and length
  • Patient Health Questionnaire-9 (PHQ-9) score of 10 or higher

Exclusion Criteria:

  • Inability to provide informed consent
  • Dementia
  • Lifetime diagnosis of bipolar I or II disorder, schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, or current psychotic symptoms
  • High risk for suicide and unable to be managed safely in the clinical trial
  • Contraindication to proposed study medications, as determined by study physician including history of intolerance or non-response to proposed medications.
  • Non-correctable, clinically significant sensory impairment interfering with participation
  • Unstable medical illness, including delirium, uncontrolled diabetes mellitus, hypertension, hyperlipidemia, or cerebrovascular or cardiovascular risk factors that are not under medical management.
  • Moderate to severe substance or alcohol use disorder

Join this Trial

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Study Stats
Protocol No.
17-001218
Category
Semel Institute (Psychiatry)
Contact
RAQUEL HERNANDEZ SOTOMAYOR
Location
  • UCLA Westwood
For Providers
NCT No.
NCT02960763
For detailed technical eligibility, visit ClinicalTrials.gov.