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PED NEONAT 20-000599 Fetal Body Composition

About

Brief Summary

Obesity is an ongoing public health problem that is difficult to treat. There is evidence that obesity has fetal origins. Body composition, including visceral, subcutaneous, brown, and hepatic fat have been found to be important predictors in obesity and metabolic syndrome. Magnetic resonance imaging (MRI) can quantify body composition that does not require radiation but is motion limited. The investigators have developed a motion-compensated MRI sequence, also known as "free breathing" MRI. In this study, the investigators plan to obtain free-breathing MRIs of pregnant women in the third trimester of pregnancy. MRIs will be obtained from healthy mothers, mothers with growth-restricted fetuses, and mothers with gestational diabetes. The different types of adipose tissue will be measured and compared between groups and correlated to birth growth parameters. The goal is this study is to assess if motion-compensated MRI can help predict early growth patterns in infancy.

Primary Purpose
Other
Study Type
Interventional
Phase
Phase 1

Eligibility

Gender
Female
Healthy Volunteers
Yes
Minimum Age
18 Years
Maximum Age
N/A

Inclusion Criteria:

  • Pregnant women with singleton pregnancies (healthy cohort)
  • Pregnant women with fetuses with weights < 10th percentile weight for gestational age (IUGR cohort)
  • Pregnant women with gestational diabetes (diabetes cohort)

Exclusion Criteria:

  • Pregnant minors
  • Major congenital anomalies or disease processes in the fetus
  • Fetus with known chromosomal anomalies
  • Mothers who do not plan to deliver at UCLA
  • Multiple pregnancy (i.e. twins, triplets, etc)
  • History of claustrophobia
  • Contraindications to MRI such as metallic devices in the body that are not MRI compatible

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Study Stats
Protocol No.
20-000599
Category
Pediatrics
Principal Investigator
Contact
KATIE STROBEL
Location
  • UCLA Santa Monica
  • UCLA Westwood
For Providers
NCT No.
NCT04508751
For detailed technical eligibility, visit ClinicalTrials.gov.