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Displaying 1 - 20 of 21

Open Actively Recruiting

Influenza and other Viruses in the acutelY ill: Adult Inpatient SARS-CoV-2 Vaccine Effectiveness Surveillance

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Contact: TREVOR FRANKEL
Open Actively Recruiting

The Effect of the COVID-19 Pandemic on Glaucoma Care

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: All
Contact: Margarita Gonzalez
Investigator: Simon K. Law, MD
Open Actively Recruiting

Use of Multi-modal (MMHealth) Remote Audio and Video Sensing for Estimation of Physiological Vital Signs in Hospitalized and Non-Hospitalized Patients

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: All
Contact: LALEH JALILIAN
Open Actively Recruiting

COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders

This is a randomized, multi-site, adaptive, open-label clinical trial comparing the immune response to different additional doses of COVID-19 vaccine in participants with autoimmune disease requiring immunosuppressive medications. All study participants will have negative serologic or sub-optimal responses (defined as a Roche Elecsys® Anti-SARS-CoV-2 S (RBD) result ≤ 200 U/mL) to initial COVID-19 vaccine regimen with Moderna COVID-19 vaccine, Pfizer-BioNTech COVID-19 vaccine, or Janssen COVID-19 vaccine.

The study will focus on 5 autoimmune diseases in adults: - Systemic Lupus Erythematosus (SLE) - Rheumatoid Arthritis (RA) - Multiple Sclerosis (MS) - Systemic Sclerosis (SSc), and - Pemphigus. This study will focus on 4 autoimmune diseases in pediatric participants: - Systemic Lupus Erythematosus (SLE) - Juvenile Idiopathic Arthritis (JIA) - Pediatric-Onset Multiple Sclerosis (POMS) - Juvenile Dermatomyositis (JDM)

Phase: Phase 2
Primary Purpose: Prevention
Gender: All
Open Actively Recruiting

ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo plus current SOC.

Phase: Phase 3
Primary Purpose: Treatment
Gender: All
Contact: Julia Vargas
Open Actively Recruiting

Functional, imaging, and respiratory evaluation in CORAL: FIRE CORAL

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Contact: Julia Vargas
Investigator: Nida Qadir, MD
Open Actively Recruiting

Adult Inpatient SARS-CoV-2 Vaccine Effectiveness Surveillance

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Nida Qadir
Investigator: Nida Qadir, MD
Open Actively Recruiting

Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE

This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic and additional strategies for prevention of adverse outcomes in COVID-19 positive inpatients

Phase: Phase IV
Primary Purpose: Treatment
Gender: All
Age Group: Adults
Contact: Julia Vargas
Investigator: George W. Lim, MD
Open Actively Recruiting

Surveillance of Respiratory Viruses in the Critically Ill: 2020-2021 IVY Network Surveillance Study

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Adreanne Rivera
Investigator: Nida Qadir, MD
Open Actively Recruiting

Innovative Support for Patients With SARS-COV2 Infections (COVID-19) Registry (INSPIRE)

The Innovative Support for Patients with SARS COV-2 Infections Registry (INSPIRE) study is a CDC-funded COVID-19 project to understand the long-term health outcomes in recently tested adults, both negative and positive, who have suspected COVID symptoms at the time of their test. Participants will complete short online surveys every 3 months for 18 months, share information about their health using a secure web-based platform, and are compensated for their time.

Gender: All
Age Group: Adults
Contact: COVID19 INSPIRE Registry
Open Actively Recruiting

Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Remdesivir (GS-5734™) in Participants From Birth to < 18 Years of Age With Coronavirus Disease 2019 (COVID-19)

The primary objectives of this study are to evaluate the safety, tolerability, and pharmacokinetics (PK) of remdesivir (RDV) in participants with laboratory-confirmed coronavirus disease 2019 (COVID-19) aged 0 days to < 18 years.

Phase: Phase II/III
Primary Purpose: Treatment
Gender: All
Age Group: Children
Contact: Jaime Deville
Open Actively Recruiting

COVID-19 Questionnaire in UCLA Rheumatoid Arthritis Patients

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Nicolette Morris
Open Actively Recruiting

COVID-19 Surveillance in Healthcare Workers and Patients: Observational Studies from the Influenza Vaccine Effectiveness in the Critically Ill (IVY) Network

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Nida Qadir
Investigator: Nida Qadir, MD
Open Actively Recruiting

Acupressure for COVID-19 Related Quality of Life and Stress

This study is being conducted to evaluate the efficacy of acupressure in promoting health and well-being among healthcare workers during the COVID-19 pandemic. The investigators hypothesize that providing participants with a remote and standardized self-acupressure training program will improve HRQOL and the perception of stress. In the event that the study demonstrates acupressure to be safe and effective for this indication, the training could be scaled up and deployed at low-cost nationally and internationally.

Phase: N/A
Primary Purpose: Treatment
Gender: All
Age Group: Adults
Contact: Ryan Abbott
Investigator: KaKit P. Hui, MD
Open Actively Recruiting

COVID Evaluation of Risk for Emergency Departments (COVERED) Project

This CDC sponsored surveillance project is designed to assess risk exposures and COVID-19 infections among working emergency department personnel. The project will require participants to provide ongoing information on risk exposures, and will collect additional information on institutional and community risks. These risk assessments will be combined with assessment of disease status, as determined by serologic testing at two-week intervals. The goal of the project is to identify the most important and potentially correctable risk factors that emergency department personnel face while dealing in with the coronavirus pandemic.

Age Group: Adults
Contact: Julia Vargas
Open Actively Recruiting

Cardiomyocyte Transcriptome Remodeling During SARS-CoV-2 Infection

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Jennifer Scovotti
Investigator:
Thomas Vondriska
Open Actively Recruiting

An observational study evaluating viral shedding and development of immune responses in mother-infant pairs affected by COVID-19

The goal of this study is to understand how pregnant women and their newborn babies respond to SARS-CoV-2 infection in pregnancy, the virus responsible for COVID-19. The two main purposes of the study are: 1) to evaluate for the presence of the virus and development of antibodies in pregnant women diagnosed with COVID-19 and their newborn infants over time, and 2) to monitor markers of disease severity in the same blood samples. The research study will last one year. We will collect blood samples from you to check for the presence of antibodies and markers of disease severity at the time of enrollment, at delivery, 6-weeks, 6-months and 12-months. We will collect blood samples from your baby at 24-hours of life (at the hospital, with routine labs), at 6 months, and 12 months. We will also collect nasopharyngeal swabs from you at delivery to detect the presence of virus in your nose, and from your baby within 48 hours of life. We expect you will be in this research study for a total of 4 visits for you and your baby, with each evaluation lasting approximately 30 minutes until 1 year after birth.

Age Group: All
Contact: Tara Kerin
Open Actively Recruiting

Role of Children in Transmission of COVID-19 to Immunocompromised Patients

This is a study of immunosuppressed individuals living in households with and without children to assess the role of household contact with children in the transmission of SARSCoV-2 to immunocompromised individuals. Through careful collection of epidemiological data in combination with biological specimens, risk factors for SARS-CoV-2 in immunocompromised individuals will be identified. During the initial visits, informed consent will be obtained and consented participants will complete an initial questionnaire and provide biological specimens including nasal swabs, saliva and blood. Thereafter, participants will complete at-home saliva collections and questionnaires on a weekly basis for 6 months. If our research-use only SARS-CoV-2 test is positive, participants will be referred immediately for medical attention and will be followed every 3 days with nasal swabs and saliva samples and weekly blood specimens and optional rectal swabs or fresh stool collection. Additionally, participants will be contacted by telephone at 1 year for follow-up.

Phase: N/A
Gender: All
Age Group: All
Contact: Mikayla Marvis Henderson
Open Actively Recruiting

Covid-19 Critical Care Consortium Incorporating the ExtraCorporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Disease (ECMOCARD)

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: All
Contact: Jennifer Scovotti
Open Actively Recruiting

Assessment of potential risk factors for 2019-novel coronavirus (SARS-CoV-2) infection among high-risk populations in health care and emergency service settings

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Faith Landsman
Investigator:
Anne Rimoin