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Displaying 1 - 3 of 3

Open Actively Recruiting

The role of Pink1/Parkin in the intestinal epithelium

The purpose of this study is to compare gut biopsies taken from Parkinson’s Disease (PD) patients with and without mutations in PINK1 and PRKN and healthy adults to find the differences in gut leakiness, gut inflammation and gut oxidative stress. We are hoping to improve our understanding of the role of the gut in PD, which may lead to new diagnostic tests and improved treatment.

Age Group: Adults
Contact: Melissa Arevalo
Open Actively Recruiting

Sleep and Healthy Aging Research for Depression (SHARE-D) Study

Late-life depression is a significant public health concern, and effective interventions for prevention and treatment are needed. Insomnia and inflammation are modifiable targets for depression prevention, and this study is significant in using an experimental approach (i.e., inflammatory challenge) to probe acute inflammatory- and depression responses as a function of insomnia, which will inform identification of molecular targets for pharmacologic interventions, and improvement of insomnia treatments to prevent depression in older adults.

Project

Phase: Phase 1
Primary Purpose: Other
Gender: All
Age Group: Adults
Contact: Nina Sadeghi
Investigator:
Michael Irwin
Open Actively Recruiting

Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Non-infectious intermediate, posterior, and panuveitides are chronic, potentially-blinding diseases. Vision-threatening cases require long-term therapy with oral corticosteroids and immunosuppression. Based upon preliminary data, adalimumab, a fully-human, anti-TNF-α monoclonal antibody, now US FDA-approved for uveitis treatment, may be a superior corticosteroid-sparing agent than conventional immunosuppressive drugs. The ADVISE Trial is multicenter randomized, parallel-treatment, comparative effectiveness trial comparing adalimumab to conventional (small molecule) immunosuppression for corticosteroid spring in the treatment of non-infectious, intermediate, posterior, and panuveitides.

Phase: Phase IV
Primary Purpose: Treatment
Gender: All
Age Group: All
Contact: Gary Holland