Open Actively Recruiting

Taking Brain Monitoring to the Next Level

About

Brief Summary

This one arm clinical study will assess the impact of a goal directed therapy intervention, aiming at optimizing depth of anesthesia and intraoperative blood pressure on the incidence of postoperative cognitive dysfunction and delirium relative to a standardized anesthetic plan. We will enroll 60 patients and will measure the neurocognitive status (MoCA test) of patients before and after surgery (at discharge, within 2 weeks after surgery and 6 months after surgery) to determine the relative impact of anesthetic care on the development of postoperative delirium and cognitive decline. All patients will have a brain scan (fMRI) before and after surgical intervention. Patients will also be asked to participate in an optional blood draw which will take place during their brain imaging visit and post operatively (within 2 days after surgery).

Primary Purpose
Prevention
Study Type
Interventional
Phase
Phase IV

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
45 Years
Maximum Age
75 Years

Inclusion Criteria:

  • 45-75 years old,
  • undergoing abdominal, orthopedic, gynecological, or urological surgery
  • expected to stay in hospital for at least 24hours

Exclusion Criteria:

  • Substantial hearing impairment or inability to understand English, since there needs to be neurocognitive testing done
  • status post craniotomy
  • severe dementia

Join this Trial

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Study Stats
Protocol No.
16-001040
Category
Anesthesiology & Perioperative Medicine
Contact
Jennifer Scovotti
Location
  • UCLA Westwood
For Providers
NCT No.
NCT04246320
For detailed technical eligibility, visit ClinicalTrials.gov.