Taking Brain Monitoring to the Next Level
This one arm clinical study will assess the impact of a goal directed therapy intervention, aiming at optimizing depth of anesthesia and intraoperative blood pressure on the incidence of postoperative cognitive dysfunction and delirium relative to a standardized anesthetic plan. We will enroll 60 patients and will measure the neurocognitive status (MoCA test) of patients before and after surgery (at discharge, within 2 weeks after surgery and 6 months after surgery) to determine the relative impact of anesthetic care on the development of postoperative delirium and cognitive decline. All patients will have a brain scan (fMRI) before and after surgical intervention. Patients will also be asked to participate in an optional blood draw which will take place during their brain imaging visit and post operatively (within 2 days after surgery).
- 45-75 years old,
- undergoing abdominal, orthopedic, gynecological, or urological surgery
- expected to stay in hospital for at least 24hours
- Substantial hearing impairment or inability to understand English, since there needs to be neurocognitive testing done
- status post craniotomy
- severe dementia