Open Actively Recruiting

Transcranial Magnetic Stimulation and Tobacco Use Disorder


Brief Summary

The purpose of this study is to determine if brain stimulation using repetitive transcranial magnetic stimulation (rTMS) directed at different parts of the brain can decrease feelings of cigarette craving and symptoms of cigarette withdrawal, and also if men and women have different responses to rTMS.

Participants will visit the University of California, Los Angeles (UCLA) five times: First, for in-person screening, then for four rTMS sessions, stimulating three different brain regions and also a sham control stimulation. The sham procedure is similar to a placebo, and will use a lower-intensity stimulation than the active stimulations. Everyone in the study will be assigned to all four treatment arms (one sham stimulation, and active stimulation of three different brain regions), and they will take place in a random order.Before and after each rTMS session, a brief MRI will be performed, and participants will be asked to fill out questionnaires that describe how they are feeling.

Primary Purpose
Study Type
Phase II


Healthy Volunteers
Minimum Age
18 Years
Maximum Age
45 Years

Inclusion Criteria:

  • 18-45 years old
  • Self-identified as male or female
  • English fluency;
  • Generally good health without cardiovascular, hepatic, renal, or autoimmune diseases; diabetes; or cancer
  • Must have smoked for 1 year; smoke 10 cigarettes per day
  • Meeting DSM 5 criteria for Tobacco Use Disorder

Exclusion Criteria:

  • Seeking treatment for nicotine dependence now or within 3 months before study entry
  • A medical condition that may compromise safety
  • A neurological disorder that would compromise compliance and/or informed consent
  • A major psychiatric disorder
  • Current drug use disorders other than Tobacco Use Disorder as defined by DSM 5
  • Recent use of drugs of abuse as shown by urine test at the screening or testing sessions
  • Smoke marijuana more than once a week
  • Use of tobacco in forms other than cigarettes more than 10 days in last month
  • Preference for menthol
  • Pregnancy or nursing
  • Seizure disorder
  • Metal implants
  • Any other circumstance that the investigators determine would compromise safety

Join this Trial

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Study Stats
Protocol No.
Semel Institute (Psychiatry)
Principal Investigator
  • UCLA Westwood
For Providers
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