Transcranial Magnetic Stimulation and Tobacco Use Disorder

About

Brief Summary

The purpose of this study is to determine if brain stimulation using repetitive transcranial magnetic stimulation (rTMS) directed at different parts of the brain can decrease feelings of cigarette craving and symptoms of cigarette withdrawal, and also if men and women have different responses to rTMS.

Participants will visit the University of California, Los Angeles (UCLA) five times: First, for in-person screening, then for four rTMS sessions, four three different brain regions. Everyone in the study will be assigned to all four treatment arms and they will take place in a random order. Before and after each rTMS session, a brief MRI will be performed, and participants will be asked to fill out questionnaires that describe how they are feeling.

Primary Purpose

Other

Study Type

Interventional

Phase

Phase II

Eligibility

Gender

All

Healthy Volunteers

Minimum Age

18 Years

Maximum Age

45 Years

Inclusion Criteria:

18-45 years old
Self-identified as male or female
English fluency;
Generally good health without cardiovascular, hepatic, renal, or autoimmune diseases; diabetes; or cancer
Must have smoked for 1 year; smoke 10 cigarettes per day
Meeting DSM 5 criteria for Tobacco Use Disorder

Exclusion Criteria:

Seeking treatment for nicotine dependence now or within 3 months before study entry
A medical condition that may compromise safety
A neurological disorder that would compromise compliance and/or informed consent
A major psychiatric disorder
Current drug use disorders other than Tobacco Use Disorder as defined by DSM 5
Recent use of drugs of abuse as shown by urine test at the screening or testing sessions
Smoke marijuana more than once a week
Use of tobacco in forms other than cigarettes more than 10 days in last month
Preference for menthol
Pregnancy or nursing
Seizure disorder
Metal implants
Any other circumstance that the investigators determine would compromise safety

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