Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
The WISDOM Study is designed to end the confusion about breast cancer screening. By comparing two safe and accepted screening recommendations, we will determine how to best screen every woman. As part of the study we will be comparing a risk based or more personalized breast cancer screening strategy to annual screening to determine if risk based screening is as safe, less morbid, enables prevention, and is accepted by women. You can self-select the study group you want to be part of or select to be randomized to a group. If you are in the Routine Annual Screening group:
You will answer several questionnaires. We will ask you questions about your health history.
We will encourage you to have an initial screening mammogram, or return for your next mammogram one year from the date of your most recent mammogram.
If our team believes you are at higher than average risk for breast cancer, you will receive a copy of your detailed risk report. You will be offered the opportunity to discuss your risk with a Breast Health Specialist over the phone. A Breast Health Specialist is an individual who has specialized training in breast cancer risk assessment and genetics. Your Specialist may recommend follow-up activities, such as more frequent screening, or suggest ideas about how you may lower your risk for breast cancer.
We will ask you to complete follow-up questionnaires every year to see if there are any changes to your family cancer history, personal history and health status. If you are in the Personalized Screening group:
You will complete a series of questionnaires and provide a saliva sample to look for inherited (genetic) risk factors for breast cancer. This test will include 9 genes (including BRCA1 and BRCA2), and a collection of single nucleotide polymorphisms, or SNPS, that have been associated with risk of breast cancer. Please see the FAQs on genetic testing for further detail.
You will receive a screening recommendation that is based on the results of your answers to the questionnaire, your mammographic breast density, and your genetic testing results. This screening recommendation letter indicates when you should return for your next mammogram based on whether you are at higher than average, average, or lower than average risk of developing breast cancer. You could be asked to return in 6 months, 1 year, 2 years, or recommended to wait until you turn 50 to start screening (if you are not 50 already).
If you are determined to be at elevated risk, you will receive a call from a Breast Health Specialist. S(he) may make recommendations about how you may reduce your risk for breast cancer.
We will ask you to complete follow-up questionnaires every year to see if there are any changes to your family cancer history, personal history and health status. You can join the WISDOM Study if you:
- are a female, age 40-74
- have never been diagnosed with breast cancer or ductal carcinoma in situ (DCIS) -You have not had both breasts surgically removed (prophylactic double mastectomy)
Eligibility: Adult female, age 40-74, no previous breast cancer For more information about the eligibility criteria for this trial Visit www.wisdomstudy.org or call UCLA WISDOM Study coordinating team at 310-794-0981
- Age 40 years to 74 years old
- Reside in California, North Dakota, South Dakota, Iowa, Minnesota, Alabama, Louisiana, Illinois OR have coverage from a participating health plan**. NOTE*: As of 2019, we are now enrolling all persons who identify as female, and will capture both their sex at birth and gender identity in the baseline survey. NOTE**: Depending on funding for study services, recruitment will expand nationwide, therefore criteria (c) will not apply if funding allows. As of 2019, recruitment is available nationwide.
- Prior Breast cancer or ductal carcinoma in situ (DCIS) diagnosis
- Prior prophylactic bilateral mastectomy
- Inability to provide consent
- Non-English or Spanish proficiency (Spanish participation available: June 2019)