Pfizer - FSGS

Drug name: PF-06730512

• Phase 2a, open-label
• Mechanism: acts as a SLIT neutralizing ligand trap to inhibit nephrin-induced actin polymerization

Key inclusion criteria:

• Age > 18 years
• eGFR > 45
• UPCR > 1.5 g/g

Exclusion:

• any immunosuppressant medications within 28 days prior to Lead-In period (besides corticosteroids, MMF, or CNIs)