Key investigator

  • Elaine Y. Hsiao, PhD

Funding

  • NIH: NIMH, NIDDK, Common Fund
  • Department of Defense
  • Simons Foundation
  • Klingenstein Fund
  • Sloan Foundation
  • Brain Research Foundation
  • UCLA CURE

Current research projects

  • Uncovering microbial modulators of neuroactive molecules as novel therapeutics
  • Investigating microbiome effects on gene-environment interactions in neurological disease

Future research directions

  • Mechanisms underlying signaling between gut microbes and brain
  • Dietary effects on the gut microbiota and implications for neurological disease
  • Microbiome as regulators of host serotonin biosynthesis and neurodevelopment

Key publications - Full list on PubMed

  1. Agirman G, Yu KB, Hsiao EY. Signaling inflammation across the gut-brain-axis. Science. 2021 Nov 26;374(6571):1087-1092. doi: 10.1126/science.abi6087. Epub 2021 Nov 25
  2. Vuong HE, Yano JM, Fung TC, Hsiao EYThe microbiome and host behaviorAnnual Review of Neuroscience. doi: 10.1146/annurev-neuro-072116-031347 (2017)
  3. Fung TC, Olson CA, Hsiao EYInteractions between the microbiota, immune and nervous systemsNature Neuroscience. 20:145-55 (2017)
  4. Yano JM, Yu K, Donaldson G, Shastri G, Ma L, Ann P, Nagler C, Ismagilov RF, Mazmanian SK, Hsiao EY. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesisCell, 161 : 264-276 (2015)
  5. Hsiao EY. Gastrointestinal issues in autism spectrum disorderHarv Rev Psychiatry, 22: 104-111 (2014)
  6. Hsiao EY. Immune dysregulation in autism spectrum disorderInt Rev Neurobiol, Konopka G., Harris A., Jenner P.(Eds.), 72 : 269-302 (2013)
  7. Hsiao EY. McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH*, Mazmanian SK, The microbiota modulates behavioral and physiological abnormalities associated with neurodevelopmental disordersCell, 155 : 1451-1463 (2013)
  8. Hsiao EY, Patterson PH. Placental regulation of maternal-fetal interactions and brain developmentDev Neurobiol, 72 : 1317-1326 (2012)
  9. Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH. Modeling an autism risk factor in mice leads to permanent immune dysregulationPNAS, 109 : 12776-12781 (2012)
  10. Malkova NV, Yu CZ, Hsiao EY, Patterson PH. Maternal immune activation yields offspring displaying the three core symptoms of autismBrain Behav Immun, 26 : 607-616 (2012)
  11. Hsiao EY, Bregere C, Malkova N, Patterson PH Modeling features of autism in rodents, In: Autism Spectrum Disorders, Amaral D.G., Dawson G., Geschwind D.H.(Eds.), 935-962 (2011) - Pediatr Res. 2011 May; 69(5 Pt 2): 34R–40R

Past GI research fellow

  • Tien A. Dong, MD, PhD (co-mentor with Jonathan P. Jacobs, MD, PhD)

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