JCCC Seed Grant (September 2019)
Dr. Jacobs was awarded a Seed Grant by the Jonsson Comprehensive Cancer Center for his proposal entitled "The intestinal microbiome in locally advanced colorectal adenocarcinoma: association with T cell infiltration into tumor and effects of surgery/chemotherapy."
DOD Award (September 2019)
Dr. Jacobs and his collaborators Andrey Mazarati and Richard Staba received a DOD Idea Development Award for their proposal titled “Gut Microbiome and Post-Traumatic Epilepsy: Biomarker and Mechanistic Implications.”
DDW 2019 (May 2019)
The Jacobs Laboratory is included on 9 abstracts accepted for oral or poster presentation at DDW, held this year in San Diego from May 18 to May 22.
CURE Annual Meeting (March 2019)
The Jacobs Laboratory presented two posters at the 2019 CURE Annual Meeting held on March 22, one of which was awarded first place in the abstract awards contest.
Crohn’s & Colitis Education Conference, Crohn’s and Colitis Foundation (March 2019)
Dr. Jacobs will be giving an educational seminar titled "The Microbiome in IBD: What is It, and How Can It Help?" on March 23 at Hoag Hospital, Irvine.
UCLA Molecular Toxicology (February 2019)
Dr. Jacobs has joined the faculty of the UCLA Molecular Toxicology Program. The Jacobs Laboratory is now accepting Mol Tox graduate students for rotations.
NIEHS R01 (October 2018)
Dr. Jacobs and his UCLA collaborators, Dr. Jesus Araujo and Dr. Tzung Hsiai, have received funding for a R01 grant to study the effect of a type of air pollution (ultrafine particles) on the gut microbiome and atherosclerosis.
Cousins Center Lectures in Psychoneuroimmunology (October 2018)
Dr. Jacobs will be giving a talk titled "Microbiome-gut-brain Interactions in Gastrointestinal Diseases" on October 25 for the Cousins Center Lectures in Psychoneuroimmunology series.
VA Merit Review (October 2018)
Dr. Jacobs and a team of VA investigators led by Dr. Joseph Pisegna have received a collaborative VA Merit Review to study the microbiome of Veterans with locally advanced colorectal cancer at multiple VA hospitals throughout the country.
UCLA Molecular, Cellular and Integrative Physiology (September 2018)
Dr. Jacobs has joined the faculty of the UCLA Molecular, Cellular, and Integrative Physiology Program. The Jacobs Laboratory is now accepting MCIP graduate students for rotations.
DOD Award (September 2018)
Dr. Jacobs and his collaborators at UCLA (Dr. Emeran A. Mayer) and USC (Dr. Lisa Aziz-Zadeh) were awarded an Idea Development Award from the DOD to study the relationships among the microbiome, brain, and behavior in autism spectrum disorder.
Jonathan P. Jacobs, MD, PhD, and Tien Dong, MD, Published in Hepatology Research (December 2018)
Dr. Jacobs, director of the Microbiome Core in the UCLA Microbiome Center, and Dr. Dong, GI fellow and T-32 recipient, examined the microbiome and bile acid in patients with advanced liver disease. Their article is titled, “Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study.” Other authors included Dr. Vatche Agopian, UCLA Department of Surgery, Dr. Francisco Durazo, chief of UCLA Transplant Hepatology, Dr. Jihane Benhammou, UCLA STAR fellow, and Dr. Shehnaz Hussain, UCLA School of Public Health and Cedars-Sinai Medical Center faculty. The array of authors represents a nice collaboration between faculty at multiple institutions. The work was supported by an NIH RO1 grant to Dr. Hussain and sub-awarded to Drs. Agopian (UCLA) and Jacobs (VA).
Oral Presentation at DDW 2018
An abstract submitted by Dr. Jacobs was selected for oral presentation on June 5, 2018, at a session during Digestive Diseases Week 2018 on Biotics in Health and Disease. It is titled “Intestinal Microbiota Predict Response to Cognitive Behavioral Therapy for Irritable Bowel Syndrome.”
Crohn's and Colitis Foundation Research Initiatives Award (June 2018)
Dr. Jacobs and his UCLA Vatche and Tama Manoukian Division of Digestive Disease collaborators Dr. Emeran A. Mayer and Dr. Jenny Sauk have received a Research Initiatives Award for their proposal titled "Brain-gut-microbiome signatures of stress-related IBD symptom flares." The team of investigators thanks the Crohn's and Colitis Foundation for their support for this innovative project.
VA Career Development Award
Dr. Jacobs has received a VA Career Development Award II starting July 1, 2018, to support research into the role of the microbiome in mediating weight loss in obese veterans treated with a high protein diet. He thanks them for their generous support.
UCLA Allergy and Immunology Seminar Series
Dr. Jacobs will give a talk at an upcoming UCLA Allergy and Immunology Seminar on December 8, 2017, titled “Defining a Pre-disease Microbial Risk State for Inflammatory Bowel Disease.”
Gut Bacteria Forecast Whether IBS Patients Will Benefit from Therapy
Helio reported (June 12, 2018) on UCLA research presented at DDW 2018 finding that certain bacteria in the gut microbiome helped predict whether cognitive behavioral therapy could reduce symptoms of irritable bowel syndrome. Dr. Jonathan Jacobs, an assistant professor in the UCLA Vatche & Tamar Manoukian Division of Digestive Diseases, was quoted.
Crohn’s and Colitis Foundation Career Development Award
Dr. Jacobs has received a Career Development Award from the Crohn’s and Colitis Foundation starting July 1, 2017. He thanks them for their generous support for his research into the role of the microbiome in inflammatory bowel disease.
Oral Presentation at DDW 2017
An abstract submitted by Dr. Jacobs was selected for oral presentation during the Research Forum on the Role of the Gut Microbiome in Immune and Inflammatory Diseases held on May 7, 2017, during Digestive Diseases Week 2017. It is titled "Crohn’s disease, obesity, and high Crohn’s disease genetic risk are associated with parallel changes in the microbiome of the cecal and sigmoid mucosal-luminal interface."
Greater Los Angeles Area VA Department of Medicine Meeting
Dr. Jacobs will present his VA-based research in a talk titled “Translational Microbiome research at the VA” at the upcoming Greater Los Angeles Area VA Department of Medicine meeting on April 13, 2017.
ACS Nano - Kavli Futures Symposium
ACS Nano is hosting a microbiome-themed symposium on March 30, 2017. Dr. Jacobs will give a talk titled “Defining a Pre-disease Microbial Risk State for Inflammatory Bowel Disease.”
Older Americans Independence Center Seminar Series
Dr. Jacobs will give a seminar on “The intestinal microbiome and its role in inflammatory disease” for the Older Americans Independence Center on February 10, 2017.
G. Oppenheimer Center for Neurobiology of Stress and Resilience Symposium 2017
Dr. Jacobs will give a talk on the UCLA Microbiome Center for this year's CNSR Symposium, “Bringing the Brain Back into Medicine: Focus on Obesity, Microbiome and Women’s Health,” on February 3, 2017.
Best Basic Science Abstract Award at the 2016 Advances in IBD
Dr. Jacobs received an award for Best Basic Science Abstract for his poster titled “Crohn’s disease, obesity, and high Crohn’s disease genetic risk are associated with parallel changes in the microbiome of the cecal and sigmoid mucosal-luminal interface” at the 2016 Advances in Inflammatory Bowel Disease conference sponsored by the Crohn’s and Colitis Foundation of America.
The AGA Posted Blog on Recent CMGH Article - "Do Relatives of Patients with IBD Also Have Intestinal Dysbiosis?"
The intestinal microbiota of many healthy, first-degree relatives of patients with inflammatory bowel diseases (IBD) is dysbiotic, signifying a pre-disease state, low-level inflammation, and susceptibility to IBD, researchers report in the November issue of Cellular and Molecular Gastroenterology and Hepatology.
UCLA Department of Medicine Grand Rounds
Dr. Jacobs will present Grand Rounds in the Tampkin Auditorium on November 2, 2016, from 8:30-9:30AM.
Accepted for Publication in Gut Microbes
"Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency" was accepted for publication in Gut Microbes. Dr. Jacobs is first author with his mentor Dr. Braun as senior author.
Accepted for Publication in Journal of Neurogastroenterology and Motility
"Chronic early-life stress in rat pups alters basal corticosterone, intestinal permeability and fecal microbiota at weaning: influence of sex" was accepted for publication in the Journal of Neurogastroenterology and Motility. Dr. Jacobs is co-first author with Nabila Moussaoui from Yvette Taché's lab.
UCLA Department of Medicine Research Day
Dr. Jacobs will give a talk titled "Defining a Pre-disease Microbial Risk State for Inflammatory Bowel Disease" during the morning plenary session of the UCLA Department of Medicine Research Day on October 1, 2016.
Accepted for Publication in Cellular and Molecular Gastroenterology and Hepatology
"A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients" was accepted for publication in Cellular and Molecular Gastroenterology and Hepatology. Dr. Jacobs is first author with his mentor Dr. Braun as senior author. The article is accompanied by a commentary written by Mark Frey entitled "Disease-Associated Microbial Communities in Healthy Relatives: A Bacteria-Filled Crystal Ball?" The results are also discussed in GI and Hepatology News >
West Los Angeles VA Grand Rounds
Dr. Jacobs will present Medicine Grand Rounds at the West Los Angeles VA Hospital, building 500, room 3231, at noon on September 21, 2016.
Accepted for Publication in Gastroenterology
"A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition" was accepted for publication in Gastroenterology. Dr. Jacobs was the lead microbiome author in this large collaborative study. The study is accompanied by a press release >
UCLA Microbiome Center
Jonathan Jacobs will give a talk during the upcoming UCLA Microbiome Center Seminar on July 15, 2-3:30pm, in the CNSI 5th Floor Presentation Space.
Oral Presentation at DDW 2016
An abstract submitted by Dr. Jacobs was selected for oral presentation during the Obesity Research Forum on May 23, 2016, at Digestive Diseases Week 2016. It is titled "A High Protein Diet Reduces Body Fat Mass and Alters the Gut Microbiome, with Expansion of Akkermansia, in a Rat Model of Diet-Induced Obesity."
Gut Microbiota for Health World Summit 2016
Dr. Jacobs was selected to present his research at the Young Investigators Workshop on March 5, 2016, during the Gut Microbiota for Health World Summit 2016. His talk is titled "A disease-associated enterotype and metabotype in healthy relatives of pediatric inflammatory bowel disease patients."
G. Oppenheimer Center for Neurobiology of Stress and Resilience Symposium 2016
Dr. Jacobs will give a state-of-the-art talk titled "Defining a Pre-disease Microbial Risk State for Inflammatory Bowel Disease" for this year's microbiome-themed CNS Symposium, Bringing the Brain Back into Medicine: Focus on the Gut Microbiome, on February 19, 2016.