Ivy La Man Law, PhD, and Clloeagues Publish Paper in the American Journal of Physiology, Gastrointestinal and Liver Physiology
"MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells" by Dr. Law and colleagues from the Pothoulakis Laboratory was published in the American Journal of Physiology describing a new role for the neuropeptide substance P as a regulator of exosome production in colonic epithelial cells. Substance P is an important neuropeptide that regulates proinflammatory responses during colonic inflammation. Exosomes are small extracellular vesicles that have an important role in cell-to-cell communications. In collaboration with the Center of Systems Biomedicine, the researchers found that exosomes generated from substance P-stimulated colonocytes promote cell proliferation and migration of neighboring colonocytes. This study also discovered that miR-21, a microRNA associated with cell proliferation, is upregulated by substance P, selectively sorted into exosomes, and transferred as exosomal cargo to neighboring naive cells to facilitate cell proliferation and migration.
Carl Rankin, PhD, and Colleagues Publish Paper in the American Journal of Physiology
In September, Dr. Rankin of the Pothoulakis Laboratory, and colleagues published a paper in the American Journal of Physiology on the IBD-associated long non-coding RNA, IFNG-AS1. Within the division, Elizabeth J. Videlock, MD, PhD, helped with data analysis and Jihane Benhammou, MD, PhD, helped with the experimental design. Additionally, Melissa Corson, MD; Nimah Ather, MD, and Jenny Sauk, MD, obtained and classified the clinical samples that were used. This study discovered that dysregulation of IFNG-AS1 had widespread effects on cytokine production by T-cells. The study also identified that a single nucleotide polymorphism in IFNG-AS1 was associated with IBD patients of Hispanic origin.
Carl Rankin, PhD, and Artin Soroosh, MS, Aricle Showcased by The American Journal of Pathology
Dr. Rankin and Mr. Soroosh’s article on the effects of an IBD-related miRNA on intestinal barrier function was recently showcased on The American Journal of Pathology’s Facebook and Twitter accounts as an Editor’s Choice article. The full text article is now freely available to everyone.
Getting Young People Excited About STEM
Amid the continuing national urgency to engage more young people in science, technology, engineering and math (STEM) education and careers, the UCLA Vatche and Tamar Manoukian Division of Digestive Diseases is providing underprivileged high school students with hands-on experiences and mentorship in STEM activities on the UCLA campus. These students get hands-on experience in Dr. Jill Hoffman's laboratory >
Jill Hoffman, PhD Article Receives Editorial Feature in Cellular and Molecular Gastroenterology and Hepatology (CMGH)
Original research from the Center from Inflammatory Bowel Disease published in CMGH, "Mesenteric Adipose-derived Stromal Cells From Crohn’s Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice with Colitis" had an editorial feature, Adipose-derived Stromal Cells: The Good Side of Fat?
Jill Hoffman, PhD, Receives AGA-Takeda Pharmaceuticals Research Scholar Award in IBD - June 2018
Dr. Hoffman, Center for Inflammatory Bowel Diseases, received the AGA-Takeda Pharmaceuticals Research Scholar Award in Inflammatory Bowel Diseases, which is a three-year career development award that totals $270,000. The objective of the award is to support young gastroenterologists working toward independent and productive research careers in IBD by ensuring that a major portion of their time is protected for research. The award will support young faculty (not fellows) who have demonstrated exceptional promise and have some record of accomplishment in research.
The American Gastroenterological Association (AGA) and the AGA Research Foundation awarded 41 investigators with more than $2 million in research funding in the 2018 award year. The awards programs are made possible thanks to generous donors and funders contributing to the AGA Research Foundation.
Learn more about the award recipients >
Harry Pothoulakis, MD Receives 2018 Section Research Mentor Award from the American Gastroenterological Association - April 2018
The AGA Institute Council Section Research Mentor Award acknowledges AGA members for their achievements as outstanding mentors in a specific area of research. Dr. Pothoulakis was acknowledged for his mentorship in the cellular and molecular gastroenterology section during Digestive Disease Week® (DDW) 2018. Congratulations! For more information and to view additional recipients >
Dr. Jill Hoffman Receives Young Investigator Award from the American Neurogastroenterology and Motility Society - December 2017
The American Neurogastroenterology and Motility Society (ANMS) was established in 1980 to promote the study neurogastroenterology and gastrointestinal motility and functional GI disorders. Jill Hoffman, PhD, UCLA Center for Inflammatory Bowel Diseases, recently received a Young Investigator Award from ANMS during the 13th Annual Young Investigator Forum held jointly with the ANMS Postgraduate Clinical Course in New York, NY. Dr. Hoffman also received a recent ANMS Research Grant to fund her ongoing research on the role of the enteric nervous system in intestinal inflammation. This is a prestigious grant, as only one award is made each year to a basic science investigator.
Eli and Edythe Broad Foundation Awards $1.2 Million to Four UCLA Researchers in IBD - December 2017
Four researchers conducting early-stage research into inflammatory bowel disease have received three-year grants totaling $1.2 million from the Eli and Edythe Broad Foundation.
Ivy Ka Ma Law, PhD, Receives Crohn’s & Colitis Foundation Career Development Award - September 2017
The Crohn’s & Colitis Foundation is a leading funder of basic and clinical research in inflammatory bowel diseases (IBD). It supports research that increases our understanding of the etiology, pathogenesis, treatment and prevention of these diseases. Career Development Awards are mentored awards intended to facilitate the development of individuals with research potential to prepare for a career of independent basic and/or clinical investigation in the area of IBD.
Dr. Jill Hoffman, PhD Receives CURE: Digestive Diseases Research Center (DDRC)/CTSI Pilot Feasibility Award 2017-2018 - July 2017
The CURE:DDRC/CTSI Pilot and Feasibility Awards are for high-quality, innovative research in the biology, function and diseases of the digestive system, with special emphasis on receptor and signal transduction mechanisms, brain-gut interactions, gastrointestinal and pancreatic physiology and inflammation, and mechanisms underlying diseases of the digestive system. Jill Hoffman, PhD, postdoctoral fellow, Center for Inflammatory Bowel Diseases, received the award for “The Role of CRHR2 Signaling in Enteric Glial Cell Function During Colitis.”