Beaven Laboratory

Key Investigator

• Simon W. Beaven, MD, PhD

Funding

• R21: Digital Fibrosis Quantification

Current Research Projects

• Role of Rab18 in stellate cell biology
• Genetics of liver fibrosis
• Development of novel biomarkers of liver fibrosis

Key Publications

1. Hui ST, Kurt Z, Tuominen I, Norheim F, Davis RC, Pan C, Dirks DL, Magyar CE, French SW, Krishnan KC, Sabir S, Campos-Perez F, Sanchez NM, Macias-Kauffer L, Leon-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ. The genetic architecture of diet-induced hepatic fibrosis in mice.  Hepatology, accepted, in press
2. **O’Mahony F, Wroblewski K, O’Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW. Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein. Hepatology, 62(2):615-26, 2015.
3. Clark PM, Flores G, Evdokimov NM, McCracken NM, Chai T, Nair-Gill E, O’Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc Natl Acad Sci USA, 111(28):E2866-84, 2014.
4. **Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. Reciprocal regulation of hepatic and adipose lipogenesis by LXRs in obesity and insulin resistance. Cell Metabolism, 18(1):106-17, 2013.
5. Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. The number of X chromosomes causes sex differences in adiposity in mice. PLoS Genetics, 8(5):e1002709, 2012.
6. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J. Clinical Investigation, 122(1): 337-47, 2012.
7. **Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. LXR signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology, 140(3): 1052-62, 2011.
8. **Beaven SW, Tontonoz, P. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med, 57:313-329, 2006.
9. Banck MS, Beaven SW, Narla G, Walsh MJ, Beutler AS, Friedman SL. KLF6 degradation after apoptotic DNA damage, FEBS Letters, 580(30):6981-86, 2006.
10. Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors, FEBS Letters, 580(20):4835-41, 2006.
11. Chen M, Beaven SW, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. J. Lipid Research, 107(2):610-18, 2005.

** = Required reading for those interested in joining the lab

Past GI Research Fellows

•  Jihane Benhammou, MD

More Information

• Beaven Laboratory research is part of the Center for Obesity and METabolic Health (COMET) >