Hsiao Laboratory

Key Investigator

• Elaine Y. Hsiao, PhD

Funding

• NIH: NIMH, NIDDK, Common Fund
• Department of Defense
• Simons Foundation
• Klingenstein Fund
• Sloan Foundation
• Brain Research Foundation
• UCLA CURE

Current Research Projects

• Uncovering microbial modulators of neuroactive molecules as novel therapeutics
• Investigating microbiome effects on gene-environment interactions in neurological disease

Future Research Directions

• Mechanisms underlying signaling between gut microbes and brain
• Dietary effects on the gut microbiota and implications for neurological disease
• Microbiome as regulators of host serotonin biosynthesis and neurodevelopment

Key Publications

1. Vuong HE, Yano JM, Fung TC, Hsiao EY (2017) The microbiome and host behavior. Annual Review of Neuroscience. doi: 10.1146/annurev-neuro-072116-031347
2. Fung TC, Olson CA, Hsiao EY (2017) Interactions between the microbiota, immune and nervous systems. Nature Neuroscience. 20:145-55
3. Yano JM, Yu K, Donaldson G, Shastri G, Ma L, Ann P, Nagler C, Ismagilov RF, Mazmanian SK, Hsiao EY, Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis, Cell, 161 : 264-276 (2015)
4. Hsiao EY, Gastrointestinal issues in autism spectrum disorder, Harv Rev Psychiatry, 22: 104-111 (2014)
5. Hsiao EY, Immune dysregulation in autism spectrum disorder, Int Rev Neurobiol, Konopka G., Harris A., Jenner P.(Eds.), 72 : 269-302 (2013)
6. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH*, Mazmanian SK, The microbiota modulates behavioral and physiological abnormalities associated with neurodevelopmental disorders, Cell, 155 : 1451-1463 (2013)
7. Hsiao EY, Patterson PH, Placental regulation of maternal-fetal interactions and brain development, Dev Neurobiol, 72 : 1317-1326 (2012)
8. Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH, Modeling an autism risk factor in mice leads to permanent immune dysregulation, PNAS, 109 : 12776-12781 (2012)
9. Malkova NV, Yu CZ, Hsiao EY, Patterson PH, Maternal immune activation yields offspring displaying the three core symptoms of autism, Brain Behav Immun, 26 : 607-616 (2012)
10. Hsiao EY, Bregere C, Malkova N, Patterson PH, Modeling features of autism in rodents, In: Autism Spectrum Disorders, Amaral D.G., Dawson G., Geschwind D.H.(Eds.), 935-962 (2011) - Pediatr Res. 2011 May; 69(5 Pt 2): 34R–40R. 

Current GI Research Fellows

• Tien Dong, MD (co-mentor with Jonathan P. Jacobs, MD, PhD)