Key Investigator
Funding
- Department of Veterans Affairs
- UCLA
Current Research Projects
My research has focused on cellular and molecular mechanisms in autoimmunity and intestinal fibrosis
- The role of cytokines responsible for inducing and/or mitigating intestinal inflammation and fibrosis
- The contribution of the gut microbiome to intestinal fibrosis using in vivo and in vitro models
Future Research Directions
- Evaluating the mechanisms responsible for induction of fibroblast-mediated fibrosis with direct and indirect microbial stimuli
- Determining novel cellular pathways involved in intestinal fibrosis and inflammation
In the News
Key Publications
- Jacob N, Kumagai K, Abraham JP, Shimodaira Y, Ye Y, Targan SR, Michelsen KS, Shih DQ. Direct Signaling of TL1A-DR3 on Fibroblasts Induces Intestinal Fibrosis In Vivo. Manuscript in preparation
- Jacob N, Jacobs J, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Balfour S, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. Differing Microbial Populations Induce Tl1a-mediated Intestinal Fibrosis. In Press, Mucosal Immunology, 2018
- Jacob N, Targan SR, Shih DQ. “Cytokine and Anti-Cytokine Agents as Future Therapeutics for Fibrostenosing IBD.” Fibrostenotic Inflammatory Bowel Disease, Ed. Florian Rieder, Springer International Publishing, 2018
- Jacob N, Targan SR, Shih DQ. Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European Gastroenterol J. 2016; 4:531-40
- Jacob N, Guo S, Mathian A, Koss MN, Gindea S, Putterman C, Jacob CO, Stohl W. B Cell and BAFF dependence of IFNa-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice. The Journal of Immunology. 2011; 186: 4984-93
- Jacob N, Stohl W. Cytokine disturbances in systemic lupus erythematosus. Arthritis Research & Therapy. 2011; 13: 228
- Jacob N, Stohl W. Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future. Autoimmunity. 2010; 43: 84-97
- Stohl W, Jacob N, Guo S, Morel L. Constitutive overexpression of BAFF in autoimmune-resistant mice drives only some aspects of systemic lupus erythematosus-like autoimmunity. Arthritis and Rheumatism. 2010; 62: 2432-42
- Jacob N, Yang H, Pricop L, Liu Y, Gao X, Zheng SG, Wang J, Gao HX, Putterman C, Koss MN,Stohl W, Jacob CO. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. The Journal of Immunology. 2009; 182: 2532-41
