Stress-Neurogastroenterology
Key Investigators
- Million Mulugeta, DVM, PhD
- Vincent Wu, PhD
- Muriel Larauche, PhD
Funding
Current Research Projects
- Mechanisms of CRF2 receptor mediated intestinal secretomotor and pain responses to stress
- TBI and intestinal inflammation
- Functional neural circuit mapping of the colon
Future Research Directions
- CRF1-CRF2 receptors cross talk in enteric neurons during stress
- CRF receptors blockade in TBI related gut dysfunction
- Electorceutical neuromodulation for gut dysmotility
Key Publications
- Million M, Wang L, Wang Y, Adelson DW, Yuan PQ, Maillot C, Coutinho SV, Mcroberts JA, Bayati A, Mattsson H, Wu V, Wei JY, Rivier J, Vale W, Mayer EA, Taché Y. CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats. Gut. 55(2):172-81 (2006) PMCID: 1856510
- Million M, Wang L, Adelson DW, Roman F, Diop L, Taché Y. Pregabalin decreases visceral pain and prevents spinal neuronal activation in rats. Gut. (10):1482-4. (2007) PMCID: PMC2000255
- Gourcerol G, Wang L, Adelson DW, Larauche M, Taché Y, Million M. Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors. Am J Physiol Gastrointest Liver Physiol. ;296(5):G992-G1002. (2009) PMCID: PMC2696213
- Gourcerol G, Wu VS, Yuan PQ, Pham H, Miampamba M, Larauche M, Sanders P, Amano T, Rivier J, Taché Y and Million M. Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gastroenterology. 140:1586-1596, (2011)
- Kashyap PC, Marcobal A, Ursell LK, Larauche M, Duboc H, Earle KA, Sonnenburg ED, Ferreyra JA, Higginbottom SK, Million M, Tache Y, Pasricha PJ, Knight R, Farrugia G, Sonnenburg JL. Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice. Gastroenterology. 2013; 144(5):967-77. PMCID:3890323
- Akiba Y, Kaunitz JD, Million M. Peripheral corticotropin-releasing factor receptor type 2 activation increases colonic blood flow through nitric oxide pathway in rats. Digestive Diseases and Sciences. 60(4):858-67. NIHMSID: (2015), PMCID: PMC4501405
- Million M, Larauche M. Stress, sex, and the enteric nervous system. Neurogastroenterology and Motility. 28(9):1283-9. (2016), PMCID: PMC5003424
- Moussaoui N, Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y. Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. Journal of Neurogastroenterology and Motility. 23(1):135-143. (2017), PMCID:PMC5216644
- Wang L, Jacobs JP, Lagishetty V, Yuan PQ, Wu SV, Million M, Reeve JR Jr, Pisegna JR, Taché Y. High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats. American Journal of Physiology. Regulatory, integrative and comparative physiology. 2017; 313(4):R473-R486. PMCID: PMC5668619
- Tache Y, Larauche M, Yuan PQ, Million M. Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract. Current Molecular Pharmacology. 11(1):51-71. (2018), PMID:28240194
