Membrane Biology Laboratory
Dr. Sachs is best known for his studies of the biochemistry and biology of the gastric H+,K+-ATPase. He showed that acid secretion by the stomach is due to an electro-neutral ATP-dependent pump, the H+-K+-ATPase. Based on this discovery, he helped to develop drugs, the PPIs, that specifically targeted this pump. These drugs are now the mainstay of treatment of peptic ulcer disease and gastro-esophageal reflux disease.
Principal Investigator
Co-Investigators
- Elizabeth Marcus, PhD
- Keith Munson, PhD
- Olga Vagin, PhD
Funding
- JC Healthcare
- NIH-NIAID
- NIH-NIDDK
- VA Merit Review
Current Research Projects
- Studying the structure-function and the intracellular assembly of the H+-K+-ATPase
- Gastric infection by Helicobacter pylori
Key Publications
- Wen Y, Scott DR, Vagin O, Tokhtaeva E, Marcus EA, Sachs G. Measurement of Internal pH in Helicobacter pylori by Using Gree Fluorescent Protein Fluorimetry. J Bacteriol 2018 Jun 25;200(14). pii: e00178-18. doi: 10.1128/JB.00178-18. Print 2018 Jul 15
- Marcus EA, Sachs G, Scott DR. Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization. Helicobacter 2018 Jun;23(3):e12490. doi: 10.1111/hel.12490. Epub 2018 Apr 25
- Abe K, Shimokawa, Naito M, Munson K, Vagin O, Sachs G, Suzuki H, Tani K, Fujiyoshi Y. The cryo-EM structure of gastric H+,K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a]pyridine inhibitors. Sci Rep. 2017 Jul 26;7(1):6632. doi: 10.1038/s41598-017-06698-8
- Scott DR, Sachs G, Marcus EA. The role of acid inhibition in Helicobacter pylori eradication. F1000Res. 2016 Jul 19;5. pii: F1000 Faculty Rev-1747. doi: 10.12688/f1000research.8598.1. eCollection 2016
- Marcus EA, Sachs G. Scott DR. Eradication of Helicobacter pylori infection. Curr Gastroenterol Rep. 2016 Jul;18(7):33. doi: 10.1007/s11894-016-0509-x
- Tokhtaeva E, Sun H, Deiss-Yehiely N, Wen Y, Soni PN, Gabrielli NM, Marcus EA, Ridge KM, Sachs G, Vazquez-Levin M, Sznajder JI, Vagin O, Dada LA. The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits. J Cell Sci. 2016 Jun 15;129(12):2394-406. doi: 10.1242/jcs.186148. Epub 2016 May 3
- Scott DR, Marcus EA, Sachs G. Vonoprazan: MarKed Competition for PPIs? Dig Dis Sci. 2016 Jul;61(7):1783-4. doi: 10.1007/s10620-016-4164-8
- Marcus EA, Tokhtaeva E, Turdikulova S, Capri J, Whitelegge JP, Scott DR, Sachs G, Berditchevski F, Vagin O. Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells. Biochem J. 2016 Jun 15;473(12):1703-18. doi: 10.1042/BCJ20160203. Epub 2016 Apr 5
- Scott DR, Marcus EA, Weeks DL, Sachs G. Mechanisms of acid resistance due to the urease system of Helicobacter pylori. Gastroenterology. 2002 Jul;123(1):187-95
Awards - Dr. Sachs has received many honors and award, including:
- Gairdner Foundation Award (2004)
- Janssen Award for Special Achievement in Gastroenterology (1998)
- William S. Middleton Award (1992)
- The William S. Middleton Award (Middleton Award) is the highest honor awarded annually by the Biomedical Laboratory Research and Development Service (BLR&D) to senior VA biomedical research scientists in recognition of their outstanding scientific contributions and achievements in the areas of biomedical and bio-behavioral research relevant to the healthcare of Veterans. Middleton Award recipients have achieved international acclaim for research accomplishments in areas of prime importance to VA's research mission.
- William Beaumont Prize in Gastroenterology (1985)
- Established in 1976, this recognition prize honors a senior investigator who has made a major contribution (a single accomplishment or series of accomplishments) that has significantly advanced care of patients with digestive diseases through clinical or translational research.
- Hoffman LaRoche Award (1982)
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