Yvette Taché, PhD
Dr. Taché is a recognized leading expert in brain-gut interactions and the role of peptides in the underlying mechanisms of stress-related gut dysfunction. She and her research team reported some of the pioneer work on the central actions of peptides to influence digestive function and feeding behavior. Her laboratory provided the preclinical ground work showing potential benefit of blocking corticotropin releasing signaling pathways in experimental models of irritable bowel syndrome and postoperative ileus. Building on her initial work on the peptidergic regulation of vagal activity to the gut, she is investigating their role in the modulation of the cholinergic anti-inflammatory reflex in the context of post operative ileus. In collaboration with Dr. Lixin Wang, they demonstrated the role of ghrelin agonists to alleviate gut motor dysfunction in models of Parkinson Disease.
Dr. Taché joined the Digestive Disease Division in 1982 and was appointed professor-in-residence in 1987 and distinguished professor since 2009. Professor Taché developed this field of research through continued competitive grants obtained from the National Institute of Health (NIH) since 1982 as well as Veteran Administration (VA) Merit Award since 2000. She is director of the Animal Core within the NIHDDK Digestive Diseases Center and a co-director of the UCLA G. Oppenheimer Center for Neurobiology of Stress and Resilience (CNSR). She published 380 peer-reviewed articles, 174 reviews, 16 editorials and edited several books. Professor Taché has been the recipients of NIHDDK MERIT Award, the Distinguished Research Award in Gastrointestinal Physiology from the American Physiological Society, the Janssen Award for Basic Research in Gastrointestinal Motility, the Senior Investigator–Basic Science Award from the International Foundation for Functional Gastrointestinal Disorders, the Research Scientist Award from the Functional Brain-Gut Research Group, the Outstanding American Gastroenterology Association (AGA) Women in Sciences, the Research Mentor Award from the AGA Institute Council (Neurogastroenterology & Motility Section), and the Senior Research Career Scientist Award and Middleton Award from the Veteran Administration and the Legion of Honor from the French Government. She served on NIH and VA grant application review panels and editorial boards of many peptides, integrative physiology, gastroenterology and stress-related journals and is an associated editor of PLoS One.
Million Mulugeta, DVM, PhD
Dr. Mulugeta graduated with a DVM from the Addis Ababa University, Faculty of Veterinary Medicine in Ethiopia. He obtained his PhD in digestive physiology/pharmacology from the Toulouse National Veterinary School and INRA Department of Pharmacology/Toxicology, Toulouse France, in 1994. Dr. Mulugeta then joined CURE/UCLA as a postdoctoral fellow in Dr. Taché’s laboratory; in 1998, he was recruited to join the research faculty at UCLA in the Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases. He is currently professor and associate director of the Models of Gastrointestinal Function and Disease Core at CURE:Digestive Diseases Research Center (CURE: DDRC), in the Department of Medicine at UCLA. He also teaches medical students at the David Geffen School of Medicine at UCLA and graduate students in UCLA’s Department of Integrative Biology and Physiology.
Dr. Mulugeta’s research focuses on brain-gut interactions and enteric neurogastroenterology. Specifically, he studies: 1) enteric neuron cellular and molecular mechanisms of CRF receptor (CRFR) signaling pathways on gut secretomotor and pain homeostasis during stress; 2) functional neural circuitries that link the brain and spinal cord to the colon, as potential targets for electroceutical neuromodulation of intractable colon diseases; and 3) brain trauma and intestinal dysfunction, with the goal of identifying the effects and enteric mechanisms behind intestinal mucosal barrier dysfunction and inflammatory responses.
Dr. Mulugeta’s works have been published in highly rated journals, including Gastroenterology, Gut, and the American Journal of Physiology, as well as in book chapters. He serves as an editorial board member on scientific journals and associate editor of the Journal of Digestive Diseases & Sciences, and was a member of an NIH special emphasis panel for grant review. The NIH and private companies have supported Dr. Mulugeta’s research. He is a fellow of the American Gastroenterological Association and recipient of the 2011 Senior Investigator in Basic Science award from the International Foundation for Functional Gut Diseases. Learn more about the Mulugeta Laboratory >
Muriel Larauche, PhD
Dr. Larauche completed her PhD in cellular, molecular and integrated physiopathology in 2003 at the University of Paul Sabatier (Toulouse, France). Then, she moved to Los Angeles as a postdoctoral fellow with Dr. Emeran A. Mayer (2003-2005) and subsequently Dr. Yvette Taché (2005-2009). Dr. Larauche is currently assistant researcher in the Vatche and Tamar Manoukian Division of Digestive Diseases, in the David Geffen School of Medicine at UCLA.
Dr. Larauche’s primary research focus is to elucidate the mechanisms by which stress influences the brain-gut axis and visceral pain differentially in males and females, with a special emphasis on recruitment of peripheral pathways (enteric nervous system, epithelial permeability, gut neuroimmune system) as a crucial step toward understanding irritable bowel syndrome (IBS) pathophysiology and improving health care. Her central hypothesis is that the higher susceptibility of females to visceral pain and constipation is related to sex-specific alterations of the immune (mast cells) and epithelial (ion channels and secretion, tight junctions and permeability) systems related to sex hormones. In collaboration with Dr. Lin Chang, she has been able to move her preclinical research activities toward translational approaches using biological samples from IBS patients recruited from the community. Her research activities also involve the development of new rodent models of visceral pain and stress. With her colleagues, Drs. Adelson, Gourcerol and Mulugeta, she developed a novel technique to monitor visceral sensitivity in mice and rats non-invasively. With these tools and approaches, she was able to demonstrate for the first time the development of stress-induced visceral analgesia in rodents, which is affected by the technique used for visceral pain monitoring.
Dr. Larauche has been the recipient of the 2013 Award for Junior Investigator in Basic Science from the International Foundation for Functional Gut Diseases (IFFGD) as well as NIH NIDDK T32 and K01 awards. Dr. Larauche’s works include more than 20 original research articles, eight review articles, and four book chapters. She also serves as editorial board member of Neurogastroenterology and Motility and the American Journal of Physiology: Gastrointestinal and Liver.
Lixin Wang, MD, PhD
Dr. Wang graduated from Peking University Medical School in China, receiving her MS in 1984 and PhD and 1987, as well as teaching human anatomy and neuroanatomy there from 1979 to 1992. She was a visiting scholar in the Department of Histology at Karolinska Institute in Stockholm, Sweden from 1989-1990 and 1992-1993. Dr. Wang joined the UCLA CURE:Digestive Disease Research Center in 1993. Currently, she is a researcher in the Brain-Gut Interaction Laboratory led by Dr. Yvette Taché at CURE and UCLA, a research scientist at West Los Angeles VA Medical Center, and principal investigator on a VA rehabilitation grant to assess the beneficial effect of ghrelin agonists in Parkinson’s disease models.
Dr. Wang’s expertise is in neuroanatomy and animal models of brain-gut interaction. Her current research projects focus on treatments of digestive and related dysfunctions of Parkinson’s disease in animal models, and on neuronal tracing of motor and sensory innervation of the colon. She has extensive experience in mapping of brain circuitry involved in brain-gut interactions in animal models of stress, and in neuropeptide- and hormone-regulated feeding and gut motility. Dr. Wang also conducted research on the innervation of epidermis of human skin and hair regrowth induced by a stress hormone antagonist in a mouse chronic stress model. She has co-authored 110 peer-reviewed articles.
Pu-Qing Yuan, PhD
Dr. Yuan received his PhD in neuroendocrinology in 1993 from Peking University Health Science Center in China. After serving as a lecturer and associate professor in the Department of Histology and Embryology at Peking University Health Science Center for two years, he went to Uppsala University in Sweden as a visiting scientist in the Neurobiology Laboratory, Department of Psychiatry (1995-1996) and subsequently moved to UCLA, where he has been since that time. Currently, Dr. Yuan is a researcher in the Vatche and Tamar Manoukian Division of Digestive Diseases at the David Geffen School of Medicine at UCLA.
Dr. Yuan has been working in the field of brain-gut interactions, and particularly focusing on the roles of CRF and its three new related peptides, urocortin (Ucn) 1, Ucn2 and Ucn3, in mediating gastrointestinal motor alterations centrally and peripherally, and on the anti-inflammatory effects of brain-vagal stimulation and ghrelin agonist HM01 on the rat postoperative ileus. On the brain-gut interaction team led by Dr. Yvette Taché, he found that CRF is expressed at the gene and protein levels in the rat colon and upregulated by endotoxin. He identified three novel CRF type 1-receptor variants in the rat pituitary, pons and medulla. Dr. Yuan’s work also provided molecular/anatomical support for an important role for CRF/CRF1 coupling in the colon as part of the local effector limb of the CRF1 receptor-mediated colonic motor response to stress. Further, his work established a distribution pattern of CRF2b receptor expression on all three Ucn ligands in the rat gastric and colonic myenteric neurons and their roles in the modulation of the motility and inflammation. He obtained evidence in the rat that abdominal surgery induced a pro-inflammatory M1 macrophage response in the gastric muscular layer that is prevented by central vagal cholinergic activation induced by central TRH or ghrelin agonist HM01. More recently, in collaboration with national and international researchers, Dr. Yuan has been involved in the NIH/SPARC-funded consortium study on comprehensive neuroanatomical and functional mapping of colonic innervation (PI/PD: Dr. Yvette Taché). As a co-investigator, he is in charge of the ENS 3D structure/phenotype and molecular profiling in the mouse, pig and human colon. He developed a CLARITY protocol applicable for 3D imaging/phenotyping of the mouse and pig colon and revealed the ENS 3D structure, connectivity among the enteric plexuses, as well as a rich innervation of the mucosa primarily from inner submucosa plexus and distinct patterns of intrinsic cholinergic innervation. Dr Yuan’s works publications include more than 40 original research articles, three review articles, and four book chapters.