Brain diseases touch the lives of millions of people. And severe symptoms such as memory loss have a progressively negative impact on quality of life.
Without a clear understanding of the mechanisms of these diseases, preventive care and curative treatments remain elusive. Experts at UCLA are hoping to change this by establishing the Clinical Neurogenomics Research Center (CNRC).
UCLA is a recognized leader in brain disease treatment and research. Doctors and patients trust us to care for both common and complex brain diseases. Our team of researchers, which includes experts in genetics and neurology, is among the most influential in the country.
Our neurogenomics program builds off the expertise of our renowned neurogenetics program. Neurogenetics specialists help determine how gene mutations:
Through this work, UCLA has become a world leader in using a focused method of genomic sequencing (exome sequencing) to diagnose rare brain diseases. We are using this information to identify new treatment options.
With the establishment of the CNRC, we are moving beyond diagnosis and exploring ways to better prevent and treat brain diseases. To this end, we are developing a unique biobank and conducting sophisticated bioinformatics analysis that facilitates novel research. Find out more by reading highlights of our work.
UCLA has been utilizing exome sequencing to diagnose brain disease since 2011. In one early success story, our team used the technology to restore mobility for a young girl with a progressive movement disorder.
The patient first came to UCLA as an 11-year-old. Her parents feared she would soon lose her ability to walk. Initial evaluations showed a high probability that the problem was genetic. Doctors used exome sequencing to learn more.
The analysis revealed a genetic defect that slowed vitamin absorption in the patient’s cells. After treatment with high-dose vitamin therapy, the symptoms rapidly dissipated. The patient was eventually able to resume normal daily activities and is now an active young adult. Read more: Why UCLA? >
We welcome inquiries and donations from organizations that support our efforts. Find out more about sponsoring neurogenomics research at UCLA by [emailing/calling us at X].
CNRC’s initial efforts are yielding discoveries that will allow us to answer important research questions. These insights are paving the way toward the next generation of brain disease care practices.
CNRC researchers are exploring topics such as:
Learn more about the Clinical Neurogenomics Research Center, including how to become a research participant, by calling us at [contact info].