This work by Dr. Lin Jiang illuminates mechanistic understanding on the spread of pathological proteins and provides structural information for the therapeutic targeting of pathological α-syn spread in Parkinson's disease progression.
Hippocampal theta rhythm is a therapeutic target because of its vital role in neuroplasticity, learning & memory. Dr. Mayank Mehta showed that theta rhythmicity is greatly amplified when rats run in virtual reality.
Cellular heterogeneity obscures the identification of cellular regulatory networks. The findings from this Nature publication by Dr. Daniel Geschwind shed new light on cell-type-specific gene regulatory networks in brain disorders.
Global outcome measures widely used in stroke clinical trials lack detail to detect changes in specific domains. In this paper, Dr. Steven Cramer discusses how NIHSS clinical data can guide the selection of relevant recovery domains.
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Drs. William Pembroke, Jessica Rexach, and Daniel Geschwind show species-dependent properties of astrocytes.
Spontaneous recovery after a stroke likely doesn't result from "remapping" in the brain, as previously thought, according to a new paper in Nature Communications from UCLA Health neurologists Drs. William Zeiger and Carlos Portera-Cailliau.
In patients with stroke, the history of penumbral tissue based on perfusion time-to-maximum delay is not well established in relation to late-window endovascular thrombectomy. Dr. David Liebeskind sought to explore this in a recent study.
In this study, Dr. Jeffrey Saver finds that statins increase the risk of hemorrhagic stroke (HS), while PCSK9Is do not increase HS risk. Therefore, PCSK9Is may be a preferred lipid-lowering medication class in patients with elevated HS risk.
Can spike and wave discharges (SWDs) and SWDs with superimposed fast ripples (SWDFRs) be biomarkers of posttraumatic epileptogenesis? This study with Udaya Kumar, Drs. Anatol Brain and Jerome Engel aimed to find out.
