Thomas C. Glenn, PhD
Associate Professor
Hospital Affiliation
David Geffen School of Medicine at UCLA
Department of Neurosurgery
PO Box 956901
Los Angeles, CA 90095-6901
Contact: (310) 206-0626
Email: [email protected]
EDUCATION
- Ph.D., University of California , Irvine , Pharmacology 1995
- B.A., Kalamazoo College , Biology Foreign Study: Münster , Germany
- Senior Research Project: The Upjohn Company, Kalamazoo , Michigan 1979
RESEARCH AREA
Dr. Glenn’s research interests have focused on the relationships between cerebral blood flow, cerebral vascular function, and metabolism. He has investigated the influence of trauma and subarachnoid hemorrhage on these cerebral parameters. Much of this research has been conducted in the critical care environment on patients with acute types of brain injury.
GRANTS
- 1R21NS057252-01A1 (Glenn) 04/01/2008 to 03/31/2010 (Role: Principle Investigator) NINDS, Propylene Glycol after TBI: Biomarker of Altered Brain Metabolism
- 1R21NS055902-01A (Martin) 04/01/2007 to 03/31/2009 (Role: Key Investigator) NINDS, Cerebral Lactate Metabolism Following Human Traumatic Brain Injury
- 1R21NS055045-01A1 (Hu) 01/15/2007 to 12/31/2008 (Role: Key Investigator) NINDS, A data Fusion Method for Bedside Monitoring of Lumped Cerebral Arterial RadII
- 1RO1 NS055045-01A1 (Vespa) 01/10/2006 to 12/31/2009 (Role: Key Investigator) NINDS, MRS Detects Metabolic Dysfunction After Brain Injury
LINKS
http://neurosurgery.ucla.edu
AWARDS/INVENTIONS
1994 ASPET Travel Award
1995 Regent’s Dissertation Fellowship
1998-2000 American Heart Association Postdoctoral Fellowship
1999 UCLA Department of Neurosurgery Young Investigator Award
2006 UCLA Department of Neurosurgery Seed Grant
PUBLICATIONS (recent articles)
- Soustiel JF , Glenn TC , Shik V , Boscardin J , Mahamid E , Zaaroor M . Monitoring of cerebral blood flow and metabolism in traumatic brain injury. J Neurotrauma. 2005 Sep;22(9):955-65.
- Oertel M, Boscardin WJ, Obrist WD, Glenn TC, McArthur DL, Gravori T, Lee, JH, Martin NA. Posttraumatic vasospasm: the epidemiology, severity, and time course of an underestimated phenomenon: a prospective study performed on 299 patients. J Neurosurg 2005, 103: 812-824
- Vespa P, Boonyaputthikul R, McArthur DL, Miller C, Etchepare M, Bergsneider M, Glenn T, Martin N, Hovda D. Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med, 2006, 34(3), 850-6.
- Hu X, Nenov V, Glenn TC, Steiner LA, Czosnyka M, Bergsneider M, Martin N. Nonlinear analysis of cerebral hemodynamic and intracranial pressure signals for characterization of autoregulation. IEEE Trans Biomed Eng 2006, 53(2), 195-209.
- Dusick JR, Glenn TC, Lee WN, Vespa PM, Kelly DF, Lee SM, Hovda DA, Martin NA. Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-(13)C(2)] glucose labeling study in humans. J Cereb Blood Flow Metab, 2007, Sep; 27( 9): 1593-602
- Hebb MO, McArthur DL, Alger J, Etchepare M, Glenn TC, Bergnsneider M, Martin N, Vespa PM. Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury. J Neurotrauma. 2007 Apr;24(4):579-90
- Hu X, Nenov V, Bergsneider M, Glenn TC, Vespa P. Martin N. Estimation of hidden state variables of the Intracranial system using constrained nonlinear Kalman filters. IEEE Trans Biomed Eng. 2007 Apr;54(4):597-610.
- Vespa PM, Miller C, McArthur D, Eliseo M, Etchepare M, Hirt D, Glenn TC, Martin N, Hovda D Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007 Dec; 35( 12): 2830-6.
- Gonzalez NR, Boscardin WJ, Glenn TC, Vinuela F, Martin N. Vasospasm probability index: a combination of transcranial doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2007 Dec; 107( 6): 1101-12.
- Marcoux J, McArthur DA, Miller C, Glenn TC, Villablanca P, Martin NA, Hovda DA, Alger JR, Vespa PM. Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury. Crit Care Med. 2008 Oct;36(10):2871-7.
- Lee DJ, Moftakhar P, Glenn TC, Vespa PM, Martin NA. Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case report. Neurosurgery. 2008 Nov;63(5):E1004-6
Read my PubMed publications
