Timothy Lane, Ph.D.

Affiliations

Associate Professor, Obstetrics and Gynecology, Biological Chemistry

Member, ACCESS Program: Dept. of Biological Chemistry, JCCC Cancer Cell Biology Program Area, JCCC Women's Cancers Program Area

Education:
Degree:	Ph.D., University of Washington, 1992
Certification Type:	Award, American Society of Cell Biology, 1989- Award, American Society of Zoologists, 1990- Award, Society for Gynecological Investigation, 1999 Award, Stop Cancer Research, 2001 Award, Alliance for Cancer Gene Therapy (ACGT), 2003-2007-01-01 Award, American Cancer Society (ACS), 2005-2009-01-01
Academic Experience:	Fellowship, NRSA, 1987-1992-01-01 Fellowship, Howard Hughes, 1993-1996-01-01 Fellowship, Massachusetts Breast Cancer, 1996- Fellowship, Department of Defense, 1997-1999-01-01 Fellowship, Margaret E. Early Foundation, 2000-2002-01-01 Fellowship, Stein-Oppenheimer, 2000

Contact Information:

Work Email Address:	tlane@mednet.ucla.edu

Laboratory Address:	Laboratory 545 BSRB CA UNITED STATES
Mailing Address:	Mailing Address 10833 Le Conte Ave MC- 174017 Los Angeles, CA 90095 UNITED STATES
Office Address:	Office BSRB 549 UNITED STATES

Home Page:	http://www.biolchem.ucla.edu/labs/Tim_Lane/index.htm

Direct Contact Information:

Fax Number:	(310) 794-5792 Fax
Work Phone Number:	(310) 794-5793 Labortatory (310) 794-5799 Office

Technical Research Interest:

Role of tumor genetics on cancer progression and endothelial stem cell recruitment in breast and ovarian cancer

Failure of various genetic control points during development, or later in life, are known to contribute to Breast Cancer, a disease which affects roughly one in eight women. During development, mammary epithelial cells undergo highly programmed pattern formation and terminal differentiation. These processes prepare the gland for milk production. Interestingly, terminal differentiation also functions to protect mammary epithelial cells from developing cancer. We use genetic analysis and developmental biology to identify genes that regulate mammary growth. In particular, we use genetic (e.g. transgenic and knockout methods) and molecular screens to identify key genes in mammary patterning and tumor development. We also use functional genomics (including ordered gene arrays, and functional screening strategies) to reveal new regulators of the process. Current projects in the lab focus on the BRCA1 tumor suppressor gene, the wnt family of signaling proteins, and the role of endothelial stem cells in tissue remodeling and tumor progression.

Additional Information:

Timothy F. Lane, Ph.D., is an Associate Professor in the Department of Biological Chemistry. His main research interests are related to defining the role of stem cells in breast cancer progression and the role of Wnt signaling in regulating various adult stem cell compartments in bone and breast biology. His work on endothelial stem cell function in breast cancer is funded by one NIH R01 grant, and a Young investigator award from the American Cancer society.

He received his Ph.D. from the University of Washington (1992), and did postdoctoral training at Harvard Medical School, in Genetics.

Dr. Lane is a member of the Jonsson Comprehensive Cancer Center at UCLA where he is part of the Cancer Cell Biology Program Area and the Women's Cancers Program Area. He is also an active member of the Orthopedics Research Center, and the Molecular Biology Institute. Dr. Lane is Co-PI of the Tumor Cell Biology Training grant and serves on the Graduate Student Committee of the Molecular Biology Institute. He is also Director of the UCLA/Laser Scanning Cytometer Shared Instrument Facility and serves on UCLA’s Embryonic Stem Cell Research Oversight Committee and the Council on Research.

Publications:

Gustavo A. Miranda-Carboni, Susan A. Krum, Kathleen Yee, Miguel Nava, Qiming E Deng, Shehla Pervin, Alicia Collado-Hidalgo, Zoran Galic, Jerome A. Zack3, Keiko Nakayama, Keiichi I. Nakayama6, Timothy F. Lane A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes and Development 2008; In press: .

Iwatsuki K. HX Liu, A Grunder, MA Singer, TF Lane, R Grosschedl, C Mistretta, R Margolskee. Role of wnt and hedgehog signaling in taste bud development. Proc. Natl. Acad. Sci. USA. 2007; 104: 2253-8..

Bennett CN, H Ouyang, YL Ma, Q Zeng, I Gerin, KM Sousa, TF Lane, V Krishnan, KD Hankenson, OA Macdougald Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. . J Bone Miner Res 2007; 22: 1924-32.

Monvoisin A, Alva JA, Hofmann JJ, Zovein AC, Lane TF, Iruela-Arispe ML. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium.. Developmental Dynamics. 2006; 235: 3413-22.

Lane TF BRCA1 and Transcription. Cancer Biol Ther. 2004; 3(6): 528-33.

Liu CH, Chang SH, Narko K, Trifan OC, Smith E, Haudenschild C, Lane TF, Hla T Mammary tumorigenesis induced by the overexpression of Cox-2.. J. Biol. Chem. 2001; 276: 18563-18569.

Lane TF, Collado-Hidalgo A Oncogenes, anti-oncogenes, and genetic regulators of vascular development.. Vascular Morphogenesis in the Female Reproductive System. 2001; Book Chapter.

Iwatsuki K, Liu HX, Gronder A, Singer MA, Lane TF, Grosschedl R, Mistretta CM, Margolskee RF Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A.. 2007; 104: 2253-8.

Chang SH, Ai Y, Breyer RM, Lane TF, Hla T The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia.. Cancer research. . 2005; 65(11): 4496-9.

Vertino AM, Taylor-Jones JM, Longo KA, Bearden ED, Lane TF, McGehee RE, MacDougald OA, Peterson CA Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts.. Molecular biology of the cell. . 2005; 16(4): 2039-48.

Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD, MacDougald OA Regulation of osteoblastogenesis and bone mass by Wnt10b.. Proceedings of the National Academy of Sciences of the United States of America. . 2005; 102(9): 3324-9.

O'Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, Zarnegar B, Perry AK, Nguyen BO, Lane TF, Taniguchi T, Miller JF, Cheng G Type I interferon production enhances susceptibility to Listeria monocytogenes infection.. The Journal of experimental medicine. . 2004; 200(4): 437-45.

Chang SH, Liu CH, Conway R, Han DK, Nithipatikom K, Trifan OC, Lane TF, Hla T Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression.. Proceedings of the National Academy of Sciences of the United States of America. . 2004; 101(2): 591-6.

Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G Toll-like receptors induce a phagocytic gene program through p38.. The Journal of experimental medicine. . 2004; 199(1): 81-90.

Krum SA, Miranda GA, Lin C, Lane TF BRCA1 associates with processive RNA polymerase II.. The Journal of biological chemistry. . 2003; 278(52): 52012-20.

Krum SA, Womack JE, Lane TF Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity.. Oncogene. . 2003; 22(38): 6032-44.

Cheng L, Reiter RE, Jin Y, Sharon H, Wieder J, Lane TF, Rao J Immunocytochemical analysis of prostate stem cell antigen as adjunct marker for detection of urothelial transitional cell carcinoma in voided urine specimens.. The
Journal of urology. . 2003; 169(6): 2094-100.

Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.. Development (Cambridge, England) . 2002; 129(17): 4159-70.

Lane TF, Lin C, Brown MA, Solomon E, Leder P Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice.. Oncogene. . 2000; 19(36): 4085-90.

UCLA Obstetrics and Gynecology

UCLA Obstetrics and Gynecology

Timothy Lane, Ph.D.

Timothy Lane, Ph.D.

Affiliations

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UCLA Obstetrics and Gynecology

UCLA Obstetrics and Gynecology

Timothy Lane, Ph.D.

Timothy Lane, Ph.D.

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