Women’s Reproductive Health Research Program Publications & Presentations

(Student investigators are in bold type)

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Publications

2018 Publications

• Guedikian AA, Lee AY, Grogan TR, Abbott DH, Largaespada L, Chazenbalk GD, Dumesic DA. Reproductive and Metabolic Determinants of Granulosa Cell Dysfunction in Normal-Weight Polycystic Ovary Syndrome Women. Fertil Steril 2018, doi:10.1016/j.fertnstert.2017.11.017 PMID 29428312.

2017 Publications

• Fisch SC, Gimeno ML, Phan JD, Simerman AA, Dumesic DA, Perone MJ, Chazenbalk GD. Pluripotent Non-Tumorigenic Multilineage Differentiating Stress Enduring Cells (Muse cells): A Seven-Year Retrospective. Stem Cell Res Ther, Oct 18;8(1):227 doi: 10.1186/s13287-017-0674-3.

2016 Publications

• Dumesic DA, Akopians AL, Madrigal VK, Ramirez E, Margolis DJ, Sarma MK, Thomas A, Grogan TR, Haykal R, Schooler TA, Okeya BL, Abbott DH, Chazenbalk GD. Hyperandrogenism Is Accompanied by Preferential Intra-Abdominal Fat Storage In Lean Polycystic Ovary Syndrome Women. J Clin Endocrinol Metab. In press.
• Cardoso RC, Veiga-Lopez A, Moeller J, Beckett E, Pease A, Keisler DH, Keller E, Madrigal V, Chazenbalk G, Dumesic D, Padmanabhan V. Developmental Programming: Impact of Gestational Steroid and Metabolic Milieu on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Sheep. Endocrinology 2016;157:522-535.
• Dumesic DA, Guedikian AA, Madrigal V, Phan J, Hill DL, Alvarez JP, Chazenbalk GD. Cumulus Cell Mitochondrial Resistance To Stress In Vitro Predicts Oocyte Development During Assisted Reproduction. J Clin Endocrinol Metab, 2016;101:2235-45.

2015 Publications

• Simerman AA, Hill DL, Goldstein E, Grogan T, Elashoff D, Manrriquez MN, Clarke NJ, Chazenbalk GD, Dumesic DA. Intrafollicular Cortisol Levels Inversely Correlate with Cumulus Cell (CC) Lipid Content As a Possible Energy Source During Oocyte Meiotic Resumption In Women Undergoing Ovarian Stimulation For In Vitro Fertilization (IVF). Fertil Steril 2015;103:249-57.
• Chithiwala ZH, Lee HC, Hill DL, Jellerette-Nolan T, Fissore R, Grow D, Dumesic DA. Phospholipase C-Zeta deficiency as a Cause for Repetitive Oocyte Fertilization Failure During Ovarian Stimulation for In Vitro Fertilization with ICSI. J Assist Reprod Genet 2015;32:1415-9.

2014 Publications

• Amin M, Simerman A, Cho M, Singh P, Briton-Jones C, Hill D, Grogan T, Elashoff D, Clarke NJ, Chazenbalk GD, Dumesic DA. 21-Hydroxylase-Derived Steroids in Follicles of Nonobese Women Undergoing Ovarian Stimulation for In Vitro Fertilization (IVF) Positively Correlate with Lipid Content of Luteinized Granulosa Cells (LGCs) as a Source of Cholesterol for Steroid Synthesis. J Clin Endocrinol Metab 2014;99:1299-1306.
• Keller E, Chazenbalk GD, Aguilera P, Madrigal V, Grogan T, Elashoff D, Dumesic DA, Abbott DH. Impaired Preadipocyte Differentiation Into Adipocytes in Subcutaneous Abdominal Adipose of PCOS-like Female Rhesus Monkeys. Endocrinology 2014;7:2696-2703.
• Simerman AA, Dumesic DA, Chazenbalk GD. Pluripotential Stem Cells Derived from Human Adipose Tissue: a New Perspective on Regenerative Medicine and Cell Therapy. Clin Transl Med 2014;3:12-20.
• Simerman AA, Perone MJ, Gimeno ML, Dumesic DA, Chazenbalk GD. A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues. Expert Opin Biol Ther 2014;7:917-929.

2013 Publications

• Singh P, Amin M, Keller E, Simerman A, Aguilera P, Briton-Jones C, Hill, DL, Abbott DH, Chazenbalk C, Dumesic DA. A Novel Approach to Quantifying human cumulus and mural granulosa cell lipid accumulation by confocal microscopy in lean women undergoing gonadotropin therapy for in vitro fertilization (IVF). JARG 2013;30:733-740.
• Chazenbalk G Singh P, Irge D, Shah A, Abbott DH, Dumesic DA. Androgens inhibit adipogenesis during human adipose stem cell commitment to predipocyte formation. Steroids 2013;78:920-6.
• Heneidi S, Simerman AA, Keller E, Singh P, Li X, Dumesic DA, Chazenbalk G. Awakened by Cellular Stress: Isolation and Characterization of a Novel Population of Pluripotent Stem Cells Derived from Human Adipose Tissue. PlosOne. 10.1371/journal.pone.0064752.

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Presentations

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2018 Presentations

• Farzan Nikou A, Fisch SC, Wright EA, Phan JD, Abbott DH, Chazenbalk GD, Dumesic DA. Hyperandrogenism in Normal Weight Women With Polycystic Ovary Syndrome Alters Subcutaneous Abdominal Adipose Stem Cell Development to Adipocytes. Androgen Excess-PCOS Society Update Meeting. Chicago Ill, March 16, 2018
• Farzan Nikou A, Fisch SC, Wright EA, Phan JD, Abbott DH, Chazenbalk GD, Dumesic DA. Hyperandrogenism in Normal Weight Women With Polycystic Ovary Syndrome Alters Subcutaneous Abdominal Adipose Stem Cell Development to Adipocytes. 100th Annual Meeting of the Endocrine Society March 17-20, 2018, Chicago IL, Abstract MON-253    

2017 Presentations

• Guedikian A,  Lee AY, Grogan TR, Abbott DH, Largaespada K, Chazenbalk GD, Dumesic DA. Increased Follicle Recruitment And Testosterone-Related Adiposity Contribute To Granulosa Cell Dysfunction In Lean Polycystic Ovary Syndrome (PCOS) Women. 73st Annual Meeting of the American Society for Reproductive Medicine, San Antonio, TX, October 28-November 1, 2017, Abstract P-363.
• Del Canto I, Dumesic DA, Chazenbalk GD. Cumulus Cell Mitochondrial Resistance to Stress Improves Following Administration of CoQ10. Annual UCLA School of Medicine Josiah Brown Poster Fair, July 21, 2017.
• Dumesic DA, Madrigal V, Fisch S, Ramirez E, Margolis D, Thomas AM, Grogan T, Abbott DH, Chazenbalk GD. Hyperandrogenism in Lean PCOS Women Is Associated With Increased Total Abdominal Fat Mass Due To Preferential Intra-Abdominal Fat Deposition. Translational Research in Reproduction National Meeting, National Institutes of Health, Bethesda, Maryland, May 24, 2017.
• Phan JD, Fisch SC, Farzan Nikou A, Wright E, Dumesic DA, Chazenbalk GD. Exaggerated Adipogenesis And Angiogenesis In Subcutaneous Abdominal Adipose Stem Cells (ASCs) of Lean Polycystic Ovary Syndrome (PCOS) Women. Translational Research in Reproduction National Meeting, National Institutes of Health, Bethesda, Maryland, May 24, 2017

2016 Presentations

• Akopians AL, Madrigal V, Fisch S,Ramirez E, Margolis D, Thomas AM, Grogan T, Abbott DA, Haykal R, Chazenbalk GD, Dumesic DA. Hyperandrogenism Is Associated With Preferential Fat Deposition Of Visceral Versus Subcutaneous (SC) Abdominal Fat In Lean Polycystic Ovary Syndrome (PCOS) Women. 72nd Annual Meeting of the American Society for Reproductive Medicine, Salt Lake City, October 15-19, 2016, O-079.
•  Phan JD Madrigal VK, Guedikian A, Ding X, Li XM, Dumesic DA, Chazenbalk GD. Immunological, Structural And Stem Cell Characteristics Of Subcutaneous (SC) Abdominal Adipose In Lean Polycystic Ovary Syndrome (PCOS) Women Versus Normoandrogenic Ovulatory (NL) Women. 72st Annual Meeting of the American Society for Reproductive Medicine, Baltimore, October 15-19, 2016, P-383.
• Guedikian AA, Lee AY, Wright EA, Madrigal VK, Phan JD, Alvarez JP, Chazenbalk GD, Dumesic DA. Cumulus Cell Mitochondrial Resistance To Stress In Vitro Predicts Oocyte Development During In Vitro Fertilization (IVF) CTSI/Catalyst UCLA-Wide Women's Health Research Symposium, April 6, 2016, Los Angeles, CA.
•  Phan JD, Fisch S, Azatyan K, Guedikian A, Madrigal V, Li X, Dumesic D, Chazenbalk G. Abnormal Genetic Profile of Subcutaneous (SC) Adipose Stem Cells (ASCs) from Lean Women with Polycystic Ovary Syndrome Women CTSI/Catalyst UCLA-Wide Women's Health Research Symposium, April 6, 2016, Los Angeles, CA, Best Student Abstract.

  2015 Presentations

• Madrigal VK, Agress A, Williamson LT, Kamdar V, Grogan T, Elashoff D, Chazenbalk GS, Dumesic DA. Inflammatory Subcutaneous (SC) Abdominal Adipose Dysfunction Accompanies Massively Enlarged Polycystic Ovaries in a Severely Insulin-Resistant PCOS Woman Receiving GnRH Agonist. 97th Annual Meeting of the Endocrine Society, San Diego CA , March 5-8, 2015, Poster THR-096.
•  Phan JD, Madrigal V, Ding X, Li X, Grogan T, Dumesic DA, Chazenbalk GD. Abnormal Subcutaneous (SC) Abdominal Adipocyte Size and SC-Adipose Stem Cell (ASC) Gene Profile Are Related to Adipogenesis and Extracellular Matrix (ECM) Formation in Lean Polycystic Ovary Syndrome (PCOS) Women. UCLA Science Poster Day, May 12, 2015, Poster 292.
•  Chazenbalk GD, Madrigal V, Ramirez E, Keller E, Haykal R, Dumesic DA. Adipogenic Determinants of Insulin Sensitivity (Si) in Lean PCOS Women. National Centers for Translational Research in Reproduction and Infertility (NCTRI) Research Meeting. National Institutes of Health, Bethesda, MD, May 19-20, 2015, P-14.
•  Dumesic DA, Phan JD, Madrigal V, Ding X, Li X, Chazenbalk GD. Abnormal Subcutaneous (SC) Abdominal Adipocyte Size and SC-Adipose Stem Cell (ASC) Gene Profile Are Related to Adipogenesis and Extracellular Matrix (ECM) Formation in Lean Polycystic Ovary Syndrome (PCOS) Women. National Centers for Translational Research in Reproduction and Infertility (NCTRI) Research Meeting. National Institutes of Health, Bethesda, MD, May 19-20, 2015, P-19.
•  Chazenbalk GD, Phan JD, Madrigal V, Ding X, Li X, Dumesic D. Abnormal Expression Of Genes Governing Adipogenesis And Extracellular Matrix (ECM) Formation In Subcutaneous Abdominal Adipose Stem Cells (SC-ASCs) Of Lean Polycystic Ovary Syndrome (PCOS) Women. 71st Annual Meeting of the American Society for Reproductive Medicine, Baltimore, October 17-21, 2015, O-49.
•  Alvarez JP, Guedikian AA, Chazenbalk GD, Dumesic DA. Resistance Of Cumulus Cell (CC) Mitochondria To Stress In Vitro As A Predictor Of Oocyte Competence During Ovarian Stimulation For In Vitro Fertilization (IVF). 71st Annual Meeting of the American Society for Reproductive Medicine, Baltimore, October 17-21, 2015, O-120.
• Dumesic DA, Madrigal V, Ramirez E, Margolis DJ, Thomas A, Grogan TR, Chazenbalk GD. Structure-Function Relationships Of Subcutaneous (SC) Abdominal Adipocytes with Metabolic Function In Lean Polycystic Ovary Syndrome (PCOS) and Normoandrogenic Ovulatory Women. 71st Annual Meeting of the American Society for Reproductive Medicine, Baltimore, October 17-21, 2015, O-53.

2014 Presentations

• Simerman AA, Hill DL, Goldstein E, Grogan T, Elashoff D, Manrriquez AN, Clark N, Chazenbalk GD, Dumesic DA. Cortisol May Promote Cumulus Cell (CC) Lipid Utilization As An Energy Source During Oocyte Meiotic Resumption in Women Undergoing Ovarian Stimulation for In Vitro Fertilization (IVF). Annual Meeting of the American Society for Reproductive Medicine, October 18-22, 2014, Accepted poster presentation.

2013 Presentations

• Chazenbalk G, Singh P, Abbott D, Dumesic D. Testosterone inhibits adipogenesis through modulation of the BMP4 signaling pathway. 94th Annual Meeting of the Endocrine Society, Houston, TX, June 23-26, 2012, Poster Sat-92.
• Singh P, Amin M, Keller E, Simerman A, Aguilera P, Briton-Jones C, Hill, DL, Abbott DH, Chazenbalk C, Dumesic DA. Quantification of cumulus and mural granulosa cell lipid content and lipid accumulation in vitro by confocal microscopy in lean women undergoing gonadotropin therapy for in vitro fertilization (IVF). 95th Annual Meeting of the Endocrine Society, San Franciso, CA , June 15-18, 2013, Poster Mon-528.
• Chazenbalk GD, Aguilera P, Keller E, Dumesic DA, Abbott DH. Altered transition of adipose stem cell commitment to early preadipocyte differentiation in subcutaneous abdominal adipose tissue of adult PCOS-like female rehsus monkeys. 95th Annual Meeting of the Endocrine Society, San Franciso, CA , June 15-18, 2013, Poster Mon-555.
• Simerman AA, Amin MB, Hill DL, Abbott DH, Chazenbalk GD, Dumesic DA. The ratio of follicle fluid (FF) cortisol level to cumulus cell (CC) lipid content is elevated in clinical pregnancy following ovarian stimulation for in vitro fertilization (IVF). Conjoint Meeting of the International Federation of Fertility Societies and the American Society for Reproductive Medicine October 1217, 2013, Abstract, O-443.
• Amin M, Singh P, Briton-Jones C, Hill D, Chazenbalk GD, Dumesic DA. Mineralocorticoid production by mural granulosa cells (MGCs) as a modulator of steroidogenesis during ovarian stimulation for in vitro fertilization (IVF). Conjoint Meeting of the International Federation of Fertility Societies and the American Society for Reproductive Medicine October 1217, 2013, Abstract O-11.

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