Position
Professor and Vice-Chair of Molecular Cell and Developmental Biology and Professor of Orthopaedic Surgery
Contact
445 Biomedical Science Research Building
615 Charles E. Yound Drive South
Los Angeles, CA 90095
email: arispe@mcdb.ucla.edu
EDUCATION
- 1983 BS, Biology, Universidade Gama Filho, Rio de Janeiro, Brazil.
- 1986 MS, Department of Histology and Embryology, Universidade Federal do Rio de Janeiro, Brazil.
- 1989 PhD, Department of Histology, Universidade de São Paulo, Brazil, and Dept. of Biological Structure, University of Washington, Seattle, WA. Thesis Advisor: E. Helene Sage.
- 1989-1993 Postdoctoral Fellow, Department of Biological Structure, University of Washington
Advisor: Dr. Helene Sage and Dr. Paul Bornstein.
RESEARCH AREA
Regulatory control of vascular morphogenesis
GRANTS
NIH
- 2002-2012 1T32 HL 69766 Vascular Biology Training Grant
- 2007-2012 NIH 1 RO1 CA126935 VEGF Signaling and Tumor Microenvironment - PI
- 2007-2012 NIH 1RO1 HL085618 Notch Signaling in Vascular Development and Homeostasis
CIRM
- 2009-2012 RB1-01328 Molecular Characterization and Functional Exploration of Hemogenic Endothelium
Leducq Foundation
LINKS
mcdb.ucla.edu/Research/Arispe/index.php
PUBLICATIONS
(Peer Review publications 2005-present)
- Lee, S., Jilani, S.M. Nikolova, G.V., Carpizo, D., and Iruela-Arispe, M.L. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J. Cell Biol. 169(4):681-691. (Cover) (Highlighted in the JCB issue and by Nature Reviews 5:500-501).
- Cho HM, Rosenblatt JD, Kang YS, Iruela-Arispe ML, Morrison SL, Penichet ML, Kwon YG, Kim TW, Webster KA, Nechustan H, Shin SU. 2005. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein. Mol Cancer Ther. Jun;4(6):956-67.
- Lee, N.V., Rodriguez-Manzaneque, J.C., Thai, S.N., Twal, W.O., Luque, A., Lyons, K.M., Argraves, W.S., Iruela-Arispe, M.L. 2005. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem. 280(41):34796-804.
- Alva, J.A., Zovein, A.C., Monvoisin, A., Murphy, T., Salazar, A., Harvey, N.L., Carmeliet, P., Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn. 235(3):759-767.
- Torres-Collado, A.X., Kisiel, W., Iruela-Arispe, M.L., Rodriguez-Manzaneque, J.C. 2006. ADAMTS1 interacts with, cleaves and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2 (TFPI-2). J Biol Chem. 281:17827-17837.
- Kern, C.B., Twal, W.O., Mjaatvedt, C.H., Fairey, S.E., Toole, B.P., Iruela-Arispe, M.L., Argraves, W.S. 2006. Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn. 235:2238-2247.
- Hashimoto-Partyka, M., Lydon, J., and Iruela-Arispe, M.L. 2006. Generation of a mouse for conditional excision of progesterone receptor (PRCE). Genesis, 44:391-395.
- Lee, N.V., Sato, M., Annis, D.S., Loo, J.A., Wu, L., Mosher, D.F. and Iruela-Arispe, M.L. 2006. ADAMTS1 mediates the release of anti-angiogenic polypeptides from TSP1 and TSP2. EMBO J. 25:5270-5283.
- Monvoisin, A., Alva, J.A., Hofmann, J.J., Zovein, A.C., Lane, T.F., and Iruela-Arispe, M.L. 2006. VE-cadherin-CreER(T2) transgenic mice: A model for inducible recombination in the endothelium. Dev. Dyn. 235:3413-3422.
- Yang, L.V., Radu, C.G., Roy, M., Lee, S., McLaughlin, J., Teitell, M.A., Iruela-Arispe, M.L. and Witte, O.N. 2007. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol. Cell Biol. 27(4): 1334-47
- Lee, M., Chen, T.T., Iruela-Arispe, M.L.,Wu, B.M., Dunn, J.C. 2007. Modulation of protein delivery from modular polymer scaffolds. Biomaterials 28(10): 1862-70.
- Hofmann, J. J., and Iruela-Arispe, M.L. 2007. Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene Expression Patterns 7(4): 461-470.
- Hellstrom, M., Phng, L.K., Hofmann, J.J., Wallgard, El., Coultas, L., Limdblom, P., Alva, J., Nilsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalen, M., Gerhardt, H., and Betsholtz, C. 2007. Dll4/Notch1 signaling is required for selection of single endothelial tip cells. Nature, 445:776-780.
- Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., Ferrara, N., Nagy, A., Roos, K.P., Iruela-Arispe, M.L. 2007. Autocrine VEGF signaling is required for vascular homesostasis. Cell, 130:691-703. (Highlighted in the Cell issue and by Nature Reviews 7:475).
- Misra, S., Lee, N., Fu, A.A., Raghavakaimal, S., Mandrekar, J., Bjarnason, H., McKusick, M.A., Iruela-Arispe, M.L., and Mukhopadhyay, D. 2008. Increased expression of a disintegrin and metalloproteinase thrombospondin 1 in thrombosed hemodialysis grafts. J. Vasc. Interv. Radiol. 19: 111-119.
- Stankunas, K., Hang, C.T., Tsun, Z.Y., Chen, H., Lee, N.V., Wu, J.I., Shang, C., Bayle, J.H., Shou, W., Iruela-Arispe, M.L., and Chang, C.P. 2008. Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev. Cell 14: 298-311.
- Guo, W., Lasky, J.L., Chang, C.J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J.E., Chen, J.Y., Iruela-Arispe, M.L., Varella-Garcia, M., and Wu, H. 2008. Multiple genetic and molecular alterations cooperatively contribute to LSC formation in a Pten-deficient leukemia model. Nature, 453:529-533.
- Suarez, Y., Fernandez-Hernando, C., Yu, J., Gerber, S.A., Harrison, K.D., Pober, J.S., Iruela-Arispe, M.L., Merkernschlager, M., and Sessa, W.C. 2008. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. PNAS 105(37):14082-14087.
- Zovein, A.C., Hofmann, J.J., Lynch, M., French, W.J., Turlo, K.A., Yang, Y., Becher, M.S., Zanetta, L., Dejana, E., Gasson, J., Tallquist, M.D., and Iruela-Arispe, M.L. 2008. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 3(6):625-636.
- Rodriguez-Manzaneque, J.C., Carpizo, D., Plaza-Calonge, M.D., Torres-Collado, A.X., Thai, S.N., Simons, M., Horowitz, A, and Iruela-Arispe, M.L. 2009. Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. Int. J. Biochem. Cell Biol., 41(4):800-810.
- Anderson, S.M., Chen, T.T., Iruela-Arispe, M.L., Segura, T. 2009. The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. Biomaterials. 30(27):4618-4628.
- Skuli, N., Liu, L., Runge, A., Wang, T., Yuan, L., Patel, S., Iruela-Arispe, M.L, Simon, M.C., Keith, B. 2009. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood. 114(2):469-477.
Reviews 2005-present
- Barber, C.L. and Iruela-Arispe, M.L. 2006. The Ever-Elusive Endothelial Progenitor Cell: Identities, Functions and Clinical Implications. Pediatr Res. 59:26R-32R.
- Hofmann J.J., Iruela-Arispe M.L. 2007. Notch signaling in blood vessels: who is talking to whom about what? Circ. Res. 100(11):1556-1568.
- Iruela-Arispe, M.L. 2008. Regulation of Thrombospondin1 by Extracellular Proteases. Curr. Drug Targets. 9(10):863-868.
- Iruela-Arispe, M.L. and Davis, G.E. 2009. Cellular and Molecular Mechanisms of Vascular Lumen Formation. Developmenal Cell 16(2):222-231.
- Speck, N.A. and Iruela-Arispe, M.L. 2009. Conditional Cre/LoxP Strategies for the Study of Hematopoietic Stem Cell Formation, Blood Cells Mol. Dis. 43:6-11.
Book Chapters 2005-present
- Iruela-Arispe, M.L. 2005. Vascular Development and Angiogenesis. Chapter in: Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-VCH. Robert Meyers, Editor-in-Chief. pp 201-232.
- Lee, N.V. and Iruela-Arispe, M.L. 2007. Thrombospondins and Angiogenesis. Chapter in: Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy. Editors: Dieter Marme and Norbert Fusening. Springer. pp 233-245.
- Lee, S. and Iruela-Arispe, M.L., 2007. The Extracellular Matrix and VEGF Processing. Chapter in: Anti-Angiogenesis, 2nd edition. The Humana Press, Inc. Editors: Lee Ellis and Beverly A. Teicher.
- Iruela-Arispe, M.L. 2008. Endothelial Cell Activation. Chapter in: Angiogenesis: An Integrative Approach from Science to Medicine. Springer, Editors: Judah Folkman and J. Figg, 35-43.
- Iruela-Arispe, M.L. and Lee, S. 2009. Mechanisms Underlying Contex-Dependent VEGF Signalin for Distinct Biological Responses. Chapter in: Handbook of Cell Signaling, Second Edition, Editors: Ralph Brandshaw and Edward Dennis, in press.
-
Torres-Collado, A.X. and Iruela-Arispe, M.L. 2009. Contributions of ADAMS and ADAMTSs during Tumor Expansion and Metastasis. Chapter in: Cancer Genome and Tumor Microenvironment, in press.
PUBMED PUBLICATIONS
Link to My Pubmed Publications >
