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UCLA Orthopaedic Surgery

UCLA Orthopaedic Surgery

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UCLA Orthopaedic Surgery

Gay Crooks, MBBS

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Gay Crooks, MBBS

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Gay Crooks, MBBS

Gay Crooks, MBBS

Position
Professor, Departments of Pathology & Laboratory Medicine and Pediatrics 
Member of the Broad Stem Cell Research Center and Jonsson Comprehensive Cancer Center at UCLA

Hospital Affiliation
Mattel Children's Hospital UCLA 

Contact
Department of Pathology & Laboratory Medicine
David Geffen School of Medicine Room A7-149 CHS
University of California Los Angeles
A7-149 CHS
    10833 Le Conte Ave
    Los Angeles CA 90095-1732
 Business Telephone  310-206-0205
 Fax Number/E-mail: 310-206-1289/[email protected]

EDUCATION

Medical School  Univ. of Western Australia (W.A.), MB, BS (equivalent to MD), 1982
Internship Sir Charles Gairdner Hospital (SCGH), Nedlands, W.A., 1982-1983
Residencies  SCGH, Resident and Med. Registrar, 1983-1984
Princess Margaret Hospital for Children (PMH), Subiaco, W.A.
Fellowship   Division of Hematology/Oncology, CHLA, 1989-1993
Licensure Fellowship of Royal Australasian College of Physicians (FRACP)
(Pediatrics) May 1991
Educational Commission for Foreign Medical
Graduates(ECFMG) examination, USA, 1988
(Certificate #427-544-2)
California Physician & Surgeon (Certificate #A053824)

RESEARCH AREA

Dr Crooks' research program was founded on the question of how to identify and functionally define human hematopoietic stem and progenitor cells. This central theme has reached over time into three related areas, 1. the characterization and manipulation of human hematopoietic stem cells and lymphoid progenitors in cord blood, bone marrow and thymus, 2. mechanisms of engraftment and thymopoiesis after bone marrow transplantation, and 3. hematopoiesis from human embryonic stem cells. Specific areas of investigation include stem and lymphoid progenitor expansion using regulated Mpl receptor dimerization, VEGF-mediated angiogenesis in the neonatal thymus, and lymphoid commitment during hESC differentiation.

GRANTS

Research Grants- current
Annual Direct Cost  %Effort         

1. Transduction of Human Stem and Progenitor Cells $278,813  20%
 NIH-NHLBI, 1 P01HL073104
 2008 - 2013, Project Leader

2. Flow Cytometry/Histology $150,219 5%
 NIH-NHLBI, 1 P01HL073104
 2008 - 2013, Core Leader
 
3. Regulated expansion lympho-hematopoietic stem and   $363,908 20%
 progenitor cells from human embryonic stem cells (hESC)
 CIRM
 Comprehensive Research Grant Program
 2007-2011, Principal Investigator
 
4. Enhancing immune reconstitution after implantation   $150,000 20%
of postnatal allogeneic thymus
NIH/NHLBI - 1R21HL95165
2008 - 2010, Principal Investigator

5. Stem Cell Therapies for Primary Immune Deficiency  $841, 903 20%
NIAID 1P01AI072686-01A1
2009-2011, Principal Investigator 

LINKS

  • uclahealth.org/ortho
  • pathology.ucla.edu
  • uclahealth.org/community-cancercare
  • stemcell.ucla.edu
  • uclaaccess.ucla.edu

AWARDS / INVENTIONS

  • Commonwealth of Australia Research Scholarship, 1973
  • Raine Foundation Vacation Scholarship, University of W.A. (U.W.A.), 1976
  • Children's Leukemia and Cancer Foundation Research Fellowship in Pediatric Oncology (Sydney, Australia), 1989
  • Telethon Trust Sammy Davis Junior Scholarship (Perth, Australia), 1990
  • Concern II Foundation Scholarship (Los Angeles, CA, 1990)
  • Athelstan and Amy Saw Medical Research Fellowship, U.W.A., 1992
  • Basil O'Connor March of Dimes Research Fellowship, 1994
  • The Leukemia & Lymphoma Society Translational Research Fellowship, 1996
  • The Leukemia & Lymphoma Society Scholar Award, 1999
  • The Leukemia & Lymphoma Society Stohlman Scholar, 2004
  • Morris and Mary Press Physician Humanism Award, CHLA, 2007

PUBMED PUBLICATIONS

Link to My Pubmed Publications >

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