John Adams, MD
Distinguished Professor and Vice Chair of Research
Research Interest: research focuses on basic and translational aspects of vitamin D synthesis, metabolism and molecular mode of action.
Maria Grazia-Ascenzi, PhD
Full Research and Adjunct Professor
Research Interest: Hierarchical simulation of bone tissue for clinical applications, bone micro-mechanics, growth plate micro-specifications, high resolution imaging of biological tissues, three-dimensional simulation of bone micro-structures, three-dimensional reconstruction from imaging stacks, and application of mathematics to investigations of biological tissue function are the main research interests.
Paul Bajaj, PhD
Emeritus Professor
Research Interest: Proteases in hemostasis and thrombosis.
Paul Benya, PhD
Recall Professor
Research Interest: Current focus is on identifying the signal transduction mechanisms of TGF-β1 and BMP in chondrocytes and their stem cell precursors, as well as the control of extracellular matrix synthesis and deposition.
Nicholas Bernthal, MD
Assistant Professor
Research Interest: Bone and soft tissue tumors, implant design, infection immunology, and antimicrobial coatings.
Fabrizio Billi, PhD
Adjunct Associate Professor
Research Interest: Evaluation of the degradation products of materials used in musculoskeletal implants and their impact on the patient’s health. Current focus is on the recovery and characterization of nanoparticles generated by the wear of orthopedic joint replacements and consequent evaluation of their local and systemic biological effects.
Pat Campbell, PhD
Adjunct Professor
Research Interest: Determining the biological factors that affect the clinical performance of prosthetic joints. Current focus is on metal-on-metal hip resurfacing components, their wear products (particularly cobalt chromium particles and ions) and the resultant biological consequences, including pseudotumors and severe allergic reactions.
Rene Chun
Associate Researcher
Current projects examine regulation of vitamin D action and MSC to bone differentiation.
John Chute, MD
Professor
Research Interest: Defining the mechanisms through which bone marrow cells regulate HSC self-renewal, repair and regeneration.
Daniel H. Cohn, PhD
Professor, Co-Director, International Skeletal Dysplasia Registry
Research interest: Research on the molecular basis and mechanisms of disease in the skeletal dysplasias, and his group has written more than 100 articles on this topic.
Gay Crooks, MBBS
Professor
Research Interest: How stem cells produce a new immune system as they develop in the thymus and how this process might be improved and developing ways to make blood and immune cells from human pluripotent stem cells to overcome shortages of matched adult stem cells.
Fabiana Csukasi
Project Scientist
Uncovering mechanisms of disease in rare genetic disorders that affect skeleton development.
Ayelet Dar
Project Scientist
Typifying perivascular progenitor cell subsets, derived from skeletal muscle and human pluripotent stem cells for improved cell-based therapy of musculoskeletal injuries.
Ivan Duran Jimenez
Project Scientist
Understanding mechanisms of skeletal disease. Precision Medicine applied to skeletal dysplasias and low mineral density diseases. Osteogenesis Imperfecta and Skeletal Ciliopathies. Genetic variance in skeletal phenotypes. Cell therapy and bone targeting. Osteoporosis and the molecular basis of skeletal aging.
Edward Ebramzadeh, PhD
Adjunct Associate Professor
Research Interest: Biomechanical design, development and evaluation of implants, including joint replacement prostheses, fracture fixation devices and related instrumentation. Implant performance evaluation and implant failure analysis using benchtop models (cadaver or artificial composite models), retrieved implants, computational models and patient outcome data. Design, development and validation of biomechanical models and apparatuses for simulation of musculoskeletal loads and kinematics. Measurement of implant loosening, wear, micromotion, fretting and corrosion. Evaluation of surgical procedures for deformity correction, including spine deformity and clubfoot. Evaluation of biomaterials for wear, tribology, biodegradation, and biocompatibility.
Denis Evseenko, MD, PhD
Assistant Professor
Research focus: 1) Ontogenesis of connective tissue in humans; 2) generation of cartilage committed progenitors from human pluripotent and mesenchymal stem cells with an ultimate goal to develop new therapeutic strategies in patients with osteoarthritis.
Eileen Fowler, PhD
Adjunct Professor Peter William Chair for the Center for Cerebral Palsy
Research Interest: Focus is in motor disorders due to developmental disabilities and genetics.
Heather Himburg, PhD
Adjunct Assistant Professor
Research Interest: How hematopoietic stem cells are regulated by neighboring cells within the bone marrow microenvironment.
Francis J. Hornicek, MD, PhD
Professor, Chair
Research Interest: Bone and soft tissue sarcoma.
Luisa Iruela-Arispe, PhD
Professor and Vice-Chair of Molecular Cell and Developmental Biology and Professor of Orthopaedic Surgery
Research Interest: Regulatory control of vascular morphogenesis.
Aaron James, MD, PhD
Adjunct Assistant Professor
Research Interest: Use of human mesenchymal stem cells in repair of musculoskeletal tissue.
Deborah Krakow, MD
Professor and Chair, Obstetrics and Gynecology, Professor, Orthopaedic Surgery, Professor, Human Genetics
Research Interest: The molecular basis of musculoskeletal disorders; Gene expression patterns in the skeleton; Disorders of joint development; Role of cilia in the skeletal dysplasias; and Osteogenesis Imperfecta.
Pavel Krejci
Project Scientist
Research focuses on morphogene signaling, receptor tyrosine kinases, regulation of primary cilia, and fibroblast growth factor pathway in disease.
Timothy Lane, PhD
Associate Professor
Research Interest: Research focuses on the role of wnt signals in the maintenance of stem cell microenvironments.
Philip Liu, PhD
Adjunct Assistant Professor
Research Area: The immune response in human disease.Research Interest: The focus of my research laboratory is to understand the factors that regulate the immune response during human disease. Currently, we are investigating the role of micronutrients such as vitamin D and vitamin A on the innate immune response to M. tuberculosis.
Daniel C. Lu, MD, PhD
Associate Professor
Research Interest: Modulating the neuronal circuitry and networks in the treatment of central nervous system disorders with the ultimate goal of restoring lost function.
Zhen Lu, PhD
Adjunct Associate Professor
Research interest: Developing and evaluating wear resistant bearing materials for prosthetic joints (hip, knee and spinal disc replacements), particularly crosslinked polyethylene and metal-metal bearings. Through the analysis of retrieved implants, evaluating how the design and bearing material affect the long-term clinical performance. Use of computer modeling (finite element analysis) to evaluate and improve the performance of many types of orthopaedic implants.
Karen Lyons, PhD
Professor
Research Interest: Growth Factor Signaling in Mammalian Development and Disease.
Keith Markolf, PhD
Professor
Research Interest: Sports medicine which include knee injury mechanisms, meniscal injuries, cruciate ligament reconstruction, loading in the wrist and forearm, ankle sprains, and internal fixation.
Sang-Hyun Park, PhD
Adjunct Professor
Research Interest: Use of Laser Doppler Flowmetry to measure the blood flow to a fracture during all phases of healing. Determining the optimal mechanical stimulation to enhance fracture healing and avoid delayed or non-union. Current focus is on metal-on-metal hip joint failure analysis.
Bruno Peault, PhD
Adjunct Professor
Research Interest: Prospective identification and purification and functional characterization of multi-lineage stem cells present in human adult organs and tissues.
Frank A. Petrigliano, MD
Assistant Professor
Research Interest: Cartilage repair and transplantation.
Sophia Sangiorgio, PhD
Adjunct Associate Professor
Research Interest: Evaluating the biomechanical performance and durability of orthopaedic implants, devices, and surgical procedures, particularly joint reconstruction, fracture fixation, and spine stabilization. Designing custom apparatuses to apply physiological loads and motions to implant-bone constructs to determine how their clinical performance is affected by the design of the implant, and the strength and stability of the fixation.
Fu-Wen Shen, PhD
Adjunct Associate Professor
Research Interest: Development and evaluation of of wear resistant bearing materials for artificial joints, including hip, knee and spinal disc replacements. Current focus in on the resistance to oxidative degradation of crosslinked polyethylenes during extended use in vivo.
Chia Soo, MD
Professor
Research Interest: Interest in bone and skin regenerative medicine research utilizing tissue engineering technologies.
Kang Ting, DMD
Professor
Research Interest: Interest in the molecular mechanism of craniosynostosis - premature fusion of calvarial suture and tissue engineering of bone tissues.
Yin Tintut, PhD
Adjunct Professor
Research Interest: Mechanisms of inflammation on artery wall calcification, aortic valve calcification and osteoporosis.
Kanagasabai Vadivel
Project Scientist
Research interests focus on understanding the biologic functions of proteins involved in blood coagulation and fibrinolysis.
Weiguang Wang
Project Scientist
Defining the molecular mechanisms of cartilage and bone development and discovering the molecular targets for treatment of osteoarthritis.
Howard Winet, PhD
Adjunct Professor
Research Interest: Bone microcirculation as it relates to bone wound healing, tissue engineering, ischemic osteonecrosis, biocompatibility of bone implants, exercise and external stimulation modalities such as electromagnetic fields, ultrasound and hyperbaric oxygen.
Ben Wu, PhD, DDS
Professor
Research Interest: Research focuses on the engineering of material microenvironment to control material-cell interactions.
