Evseenko, Denis MD, PhD
Position
Assistant Professor of Orthopaedic Surgery
Head, Laboratory of Connective Tissue Regeneration (LCTR)
Contact
Orthopaedic Hospital Research Center,
615 Charles E. Young Dr. South, Rm. 414
Los Angeles, CA 90095-7358
EDUCATION
- Bachelor of Medicine (MB) (First Class Honors) in Paediatrics/Neonatology.
Novosibirsk State Medical University, (Novosibirsk, Russia), 1996.
- Doctor of Medicine (MD) in Pathology/Histology/Embryology. Institute of Regional Pathology and Pathomorphology, Russian Academy of Medical Science (Novosibirsk, Russia), 1999.
- Doctor of Philosophy (PhD) in Molecular Pharmacology, The Liggins Institute, University of Auckland (Auckland, NZ), 2007.
RESEARCH AREA
Current research area: 1) Ontogenesis of connective tissue in humans; 2) generation of cartilage committed progenitors from human pluripotent and mesenchymal stem cells with an ultimate goal to develop new therapeutic strategies in patients with osteoarthritis. 3) development of antifibrotic therapies for prevention of fibrocartilage formation during regeneration/repair of articular cartilage defects.
HONORS/AWARDS
- 1995-1996 Major of Novosibirsk personal scholarship for outstanding academic achievements. Novosibirsk, Russia.
- 1996 Mayor of Novosibirsk Award for the Best Student Research Project in Medical Science, Novosibirsk, Russia.
- 1996-1999 State junior fellowship in clinical research (Novosibirsk, Russia).
- 2004-2007 Bright Feature Award, Auckland, NZ.
- 2005 New Zealand society of endocrinology award, Auckland, NZ.
- 2006 Research Innovation Award, Auckland, NZ.
- 2006 Maurice and Paykel Trust Award, Auckland, NZ.
- 2006 IFPA Charlie Loke Award, Kobe, Japan.
- 2007 Kelleher Trust Award for research innovation, Auckland, NZ.
- 2009 UCLA Eli Broad Stem Center Award, Los Angeles, USA.
- 2010 IFPA NIH Award, Santiago, Chile.
- 2011 K01 Career Development Award, NIH NIAMS, USA.
FUNDING
Dr Evseenko’s work is funded by NIH NIAMS and UCLA Broad Stem Cell Research Center.
LINKS
ortho-institute.org/research/
PUBLICATIONS (recent articles):
- Chui A, Evseenko DA, Brennecke SP, Keelan JA, Kalionis B, Murthi P. Homeobox gene Distal-less 3 (DLX3) is a regulator of villous cytotrophoblast differentiation. Placenta. 2011 Jul 29. [Epub ahead of print].
- Evseenko D, Paxton JW, Keelan JA. (2006) Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids and growth factors. Drug Metabolism and Disposition 35(4):595-601.
- Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, MacLellan R, Crooks GM. (2010) Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells PNAS 107(31):13742-7. PMCID: PMC2922221.
- Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM (2010) (2011) Dysregulated Gene Expression During Hematopoietic Differentiation From Human Embryonic Stem Cells (2010) Molecular therapy 19(4):768-81.
- Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wan XC, MacLellan R, Crooks GM. (2009) Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells and Dev 18(6): 919-28.
- Evseenko D, Paxton JW, Keelan JA (2007) The xenobiotic transporter ABCG2 plays a novel role in trophoblast differentiation. Placenta 28 (Suppl A):S116-20.
- Evseenko D, Paxton JW, Keelan JA (2006) ABC drug transporter expression and functional activity in trophoblast like cell lines and differentiating primary trophoblast. Am J Physiol: Reg Integr Comp Physiol 290(5):R1357-65.
- Evseenko D, Paxton JW, Keelan JA. (2006) Active transport across the human placenta: Impact on drug efficacy and toxicity. Exp Opinion Drug Metab Toxicol 2(1): 51-69.
- Evseenko D, Murthi P, Paxton JW, Emerald BS, Mohankumar KM, Lobie PE, Reid G, Brennecke SP, Kalionis B, Keelan JA. (2007) The ABC transporter BCRP/ABCG2 is a placental survival factor and its expression is reduced in idiopathic human fetal growth restriction. FASEB journal 21(13):3592-605.
- Aye IL, Paxton JW, Evseenko DA, Keelan JA (2007) Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes Placenta 28(8-9):868-77
PUBMED PUBLICATIONS
Link to My Pubmed Publications >
