Position
Professor, Departments of Pathology & Laboratory Medicine and Pediatrics
Member of the Broad Stem Cell Research Center and Jonsson Comprehensive Cancer Center at UCLA
Hospital Affiliation
Mattel Children's Hospital UCLA
Contact
Department of Pathology & Laboratory Medicine
David Geffen School of Medicine Room A7-149 CHS
University of California Los Angeles
A7-149 CHS
10833 Le Conte Ave
Los Angeles CA 90095-1732
Business Telephone 310-206-0205
Fax Number/E-mail: 310-206-1289/[email protected]
Medical School Univ. of Western Australia (W.A.), MB, BS (equivalent to MD), 1982
Internship Sir Charles Gairdner Hospital (SCGH), Nedlands, W.A., 1982-1983
Residencies SCGH, Resident and Med. Registrar, 1983-1984
Princess Margaret Hospital for Children (PMH), Subiaco, W.A.
Fellowship Division of Hematology/Oncology, CHLA, 1989-1993
Licensure Fellowship of Royal Australasian College of Physicians (FRACP)
(Pediatrics) May 1991
Educational Commission for Foreign Medical
Graduates(ECFMG) examination, USA, 1988
(Certificate #427-544-2)
California Physician & Surgeon (Certificate #A053824)
Dr Crooks' research program was founded on the question of how to identify and functionally define human hematopoietic stem and progenitor cells. This central theme has reached over time into three related areas, 1. the characterization and manipulation of human hematopoietic stem cells and lymphoid progenitors in cord blood, bone marrow and thymus, 2. mechanisms of engraftment and thymopoiesis after bone marrow transplantation, and 3. hematopoiesis from human embryonic stem cells. Specific areas of investigation include stem and lymphoid progenitor expansion using regulated Mpl receptor dimerization, VEGF-mediated angiogenesis in the neonatal thymus, and lymphoid commitment during hESC differentiation.
Research Grants- current
Annual Direct Cost %Effort
1. Transduction of Human Stem and Progenitor Cells $278,813 20%
NIH-NHLBI, 1 P01HL073104
2008 - 2013, Project Leader
2. Flow Cytometry/Histology $150,219 5%
NIH-NHLBI, 1 P01HL073104
2008 - 2013, Core Leader
3. Regulated expansion lympho-hematopoietic stem and $363,908 20%
progenitor cells from human embryonic stem cells (hESC)
CIRM
Comprehensive Research Grant Program
2007-2011, Principal Investigator
4. Enhancing immune reconstitution after implantation $150,000 20%
of postnatal allogeneic thymus
NIH/NHLBI - 1R21HL95165
2008 - 2010, Principal Investigator
5. Stem Cell Therapies for Primary Immune Deficiency $841, 903 20%
NIAID 1P01AI072686-01A1
2009-2011, Principal Investigator
