Research and Clinical Trials
UCLA conducts research for a wide range of medical disorders and
offers patients opportunities to participate in research and
Visit our Office of Clinical Trials website for
more information about clinical trials.
Below are some featured trials at UCLA. Click here
for a PDF of these trials. You may also visit the links to
the right for additional trials from our clinical departments.
UCLA Aftercare Research Program
The Aftercare Research Program at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA will provide free treatment and assessment for participants in clinical research studies designed to improve understanding of psychotic disorders and develop more effective treatments. An initial diagnostic interview will determine a patient’s eligibility. The study will include individual case management, group therapy and treatment with an antipsychotic medication called risperidone. An initial period on risperidone is a requirement of this study; this may require changing the medications the patient may be taking prior to study enrollment. Patients' family members will be invited to join family psychoeducational meetings.
Info: (310) 206-3142 or email email@example.com, firstname.lastname@example.org or www.semel.ucla.edu/aftercare
UCLA Alcohol Clinical Trial
Is your drinking out of control? Have you thought about cutting back or quitting drinking? If so, you may be eligible to participate in a UCLA clinical trial studying a new medication for alcohol problems. Sponsored by the NIAAA Clinical Investigators Group (NCIG/NIAAA/NIH), this 28-week trial consists of study medication, outpatient clinic visits and monetary compensation. Study locations are available in both Westwood and Santa Monica.
Info: (310) 206-6756
Child Anxiety Study
The Child Anxiety Study, conducted by Susanna Chang, PhD, investigates the usefulness of a novel computer-based attention-training treatment for childhood anxiety. The study is seeking children ages 8 to 17 with social anxiety, generalized anxiety and separation anxiety. Parental participation is also required. The study involves four weeks of a non-medication attention-training treatment for children.
Info: (310) 825-2064
Child Attention & Real-World Emotion Study
Does your child have frequent worries or fears? UCLA is recruiting children between the ages of six and nine for a study about how attention may be related to the ability to manage emotions like anxiety or fear. The research study involves questionnaires and interviews about you and your child’s mood and behaviors, computer tasks assessing how your child processes emotional information (like facial expressions), recording your child’s brain waves while he/she views emotional information, two weekends of short (5-10 minute) phone interviews about your child’s activities and emotions and short (45-second) audio recordings of your child’s emotional expressions. The study also involves two visits to our research laboratory (about 3 hours total) and two weekends of phone calls. We will also ask parents to complete a few questionnaires six and 12 months after the final laboratory visit. Participants will receive compensation for their time and transportation costs. Interested families may be provided with clinical referrals. There are no medical risks associated with this study.
Info: (310) 835-2701
Coronary Artery Disease Treatment
This clinical trial compares the safety and efficacy of the Absorb BVS, an experimental absorbable stent that dissolves over one to two years, to Xience, a commercially available metallic stent. Eligible participants are adults with coronary artery disease who are scheduled to undergo interventional coronary artery procedures, have stable angina pectoris and require a heart catheterization with a high likelihood of needing a coronary angioplasty. Prior to the procedure, participants will complete an interview, blood tests, an electrocardiogram test and a health assessment questionnaire. Women of childbearing potential will also undergo a pregnancy test. During the procedure, all study participants will receive a coronary angiogram to evaluate the narrowed heart arteries and determine whether the volunteer can be registered in the study. Volunteers will meet with a registered dietician who will provide instructions on following an American Heart Association low-fat diet during the study. Participation in the study will last five to seven years and include up to 10 post-study visits. Follow up will include a telephone call or office visit after one, three, six and nine months, and at the end of each year. Study volunteers will be randomly assigned to treatment and will be informed of which stent they received at the end of the study.
Info: (310) 794-4797
Carotid Revascularization Endarterectomy versus Stenting Trial-2 (CREST-2)
CREST-2 is a multi-institutional randomized trial involving asymptomatic patients with hemodynamically significant carotid artery stenosis. Sponsored by the National Institutes of Health, this study is designed to test the hypothesis that intensive medical therapy is not inferior to invasive interventions such as carotid endarterectomy, carotid stent/angioplasty or intensive medical therapy in the prevention of stroke.
Info: (310) 206-1115
For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy or loss of interest and pleasure in normal activities, UCLA is conducting a 12-month research study using an experimental combination of two drugs and a placebo (an inactive substance). The study seeks participants 60 years of age or older who are not currently receiving any psychiatric treatment with medications. Medical and psychiatric evaluations and limited physical exams are provided as a part of the study. Participants will undergo a PET scan and MRI scan. Evaluations and study medications are provided at no charge.
Info: (310) 794-9523 or (310) 983-3375
Depression in Older Adults
For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy, or loss of interest and pleasure in normal activities, UCLA is conducting a 12-month research study comparing levomilnacipran (FETZIMA®) to placebo (an inactive substance) for treatment of geriatric depression. If you are 60 years of age or older, you may qualify. A complete psychiatric evaluation, physical exam and MRI scan are provided as a part of the study. All participants will be given either levomilnacipran (FETZIMA®) or a placebo and will be compensated up to $200.
Info: (310) 794-9523 or (310) 794-4619
UCLA research study seeks healthy adults between the ages of 21-45 to test the effects of electronic (E)-cigarettes on blood vessel function and blood levels of anti-oxidants (protective compounds). Current tobacco cigarette smokers or current e-cigarette users may be eligible. No dual users. The study involves one visit, approximately 3.5 hours. Participants will undergo blood tests and a scan to measure blood vessel inflammation. Compensation is $100 at the completion of the study.
Info: (310) 825-3510
UCLA is seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on blood vessel function. Must be a cigarette smoker, E-Cigarette user, or neither. Monetary compensation provided.
Info: (310) 825-3510 or email@example.com.
Seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on sympathetic nerve activity (nerves that carry adrenaline) and blood levels of anti-oxidants . Must be a NON-SMOKER or you must be an E-cigarette user. The study will involve either 1 two hour visit, or 3 two hour visits (depending on which group you're in) to the UCLA Clinical and Translational Research Center. Monetary compensation provided.
Info: (310) 825-3510 or firstname.lastname@example.org.
Heart Disease Treatment Study
The goal of the Heart Disease Treatment trial is to compare the safety and efficacy of Absorb, a naturally-dissolving, investigational stent, to XIENCE, an FDA-approved, commercially available metallic stent. Study researchers are seeking participants with coronary artery disease who are scheduled to undergo interventional coronary artery procedures. The trial will enroll approximately 3,000 subjects at 140 sites in the United States. Participation in the study will last five to seven years and will require up to 10 post-study visits, including a telephone call or office visit after one, three, six and nine months, and at the end of each year. Prior to the procedure, participants will complete an interview, blood tests, an electrocardiogram test and a health assessment questionnaire. Women of childbearing potential will also undergo a pregnancy test. During the procedure, all study subjects will receive a coronary angiogram to examine the narrowed heart arteries and determine whether the volunteer can be registered in the study. Study participants will meet with a registered dietician who will provide instructions on following an American Heart Association low-fat diet during the study. Study volunteers will be randomly assigned to treatment; they will find out which stent they have received at the end of the study.
Info: (310) 794-4797
Memory and Exercise Training (MET) Study
This project studies the relationship of simultaneous exercise and memory training. Volunteers 60 to 75 years of age who are in good health and living independently are encouraged to participate. The study will involve memory training, memory testing and physical exercise over the course of nine weeks. Subjects will be compensated for participation and will receive clinically relevant results of assessments.
Info: (310) 825-0545 or (310) 794-5020
Menstrual Irregularities and PCOS Study
UCLA researchers are seeking women with and
without Polycystic Ovary Syndrome (PCOS).
Participants must be 18- to 35-year-old females
who are Caucasian or non-Hispanic, have body
mass indices (BMI) between 18.5 and 25, and
have not used hormones (i.e., birth control pills
or a Mirena IUD) for the past three months.
Participants will receive extensive medical
testing (blood hormone measurements, diabetes
screening and ovarian and fat assessments) at no
charge. Blood will be drawn and a small amount
of fat will be removed for research purposes.
Only women with PCOS will take an oral pill that
contains either the drug Flutamide or a placebo
(sugar pill) for six complete 28-day cycles.
Free medical testing will be repeated at the
end of the study. Women without PCOS may
be compensated up to $300 and women with
PCOS may be compensated up to $840.
Info: (310) 825-7301 or email@example.com
Family-focused Treatment for Childhood OCD
Does your child have Obsessive Compulsive Disorder (OCD)? Does he/she: Have recurring thoughts that make no sense, but makes him or her feel bad? Wash excessively or have fear of touching “contaminated” things? Check and double-check more than necessary? Have to do things over and over again? The study is seeking teens between the ages 8 and 17 years with OCD to participate in non-medication Cognitive Behavioral Therapy (CBT). Eligible participants will receive 14 weeks of free CBT treatment that includes .
Info: (310) 794-4347
Obstructive Sleep Apnea (OSA) Research Study
UCLA researchers are seeking patients between
the ages of 21 and 75 who have recently been
diagnosed with obstructive sleep apnea (and have
not yet started treatment) to participate in a study
examining how changes in brain function and
structure relate to autonomic impairments. The
study is also seeking healthy non-smokers without
sleep disorders to serve as control subjects.
People interested in participating will go through a
screening process and those determined eligible
will be enrolled in the study. Enrolled participants
will be invited to do one or more of the following:
Magnetic resonance imaging (MRI); physiological
testing; simple, daily, home physiological testing;
and brief questionnaires with a smart phone.
Study participants will not be charged for any
study procedures and will be compensated for
Info: (323) 362-8818 or firstname.lastname@example.org
Pomegranate Juice Study
The UCLA Longevity Center is studying the effects of pomegranate juice on memory. Volunteers between the ages of 50 and 75 are needed. The study lasts one year and includes five visits to UCLA and $300 compensation for participation.
Info: (310) 825-0545
Pomegranate Juice Study and Aging
The UCLA Center for Human Nutrition is studying the effects of pomegranate juice on aging. Female volunteers between the ages of 30 and 45 are needed. The study lasts twelve weeks and includes eight visits to UCLA and $475 compensation for participation.
Info: (310) 206-8292
Computerized Treatment for Stressed Kids and Teens
Does your child often feel scared, nervous, worried or stressed? Does your child excessively worry about school, peers or current events? Does he or she have fears of being embarrassed in social situations or get upset when separated from you? Does your child: Have recurring thoughts that make no sense, but make him or her feel bad? Wash or clean excessively or have fear of touching “contaminated” things? Check and double-check more than necessary? Have to do things over and over, including ask you for reassurance that things are ok? If you answered “yes” to any of these questions, and your child is between the ages of 10 and 17, your child may be eligible to receive a free computerized treatment for anxiety. Eligible youth will receive four weeks of a novel computer-based treatment that we think might help anxiety symptoms, as well as free diagnostic and cognitive assessments.
Info: (310) 794-2215
Tai-Chi or Health Education and Wellness for Older Adults
UCLA is seeking participants 60 years of age or older who are on stable medications for depression and are suffering from depressive symptoms and lack of energy to participate in a six-month research study. The trial involves 12 weekly 60-minute sessions that consist of either a health and education wellness class or a Tai-Chi class. Participants will undergo two functional magnetic resonance imaging (fMRI) scans and a complete psychiatric evaluation. Participants will be compensated.
Info: (310) 983-3375 or (310) 794-9523
Research to Help Children with Tourette Disorder
The UCLA Childhood OCD, Anxiety and Tic Disorders Program’s clinical trial aims to determine whether a medication improves the benefit of an evidence-based treatment for Habit Reversal Training (HRT), relative to a placebo pill. In order to qualify for this study, participants must be between the ages of 8 and 17, diagnosed with Tourette Disorder or Chronic Tic Disorder, and be medication-free or on a stable dose of medication with no planned changes. Participants will receive one session of HRT and referral information to continue to receive HRT from trained providers. Participation will involve an initial visit to UCLA to assess eligibility and tic severity, random assignment to receive a medication or placebo pill, an immediately subsequent session of HRT and a follow-up visit one week after the HRT session to evaluate tic severity. Compensation will be rendered, up to $90.
Info: (310) 794-5609
Undiagnosed Diseases Network
The Undiagnosed Diseases Network (UDN) is an initiative to facilitate the diagnosis of conditions that have eluded diagnosis. The UDN is made up of clinical and research centers across the United States that work together to improve diagnosis and care of patients with undiagnosed diseases. The UDN is accepting applications for patients and families affected by mysterious conditions. An in-depth review of medical records will determine eligibility for the UDN. If accepted, patients will undergo extensive genetic testing and comprehensive evaluations at UCLA.
Info: (310) 794-3695 or email@example.com or firstname.lastname@example.org or undiagnosed.hms.harvard.edu/apply
UCLA researchers are seeking women aged
18 to 55 to help understand brain-activity
changes associated with a chronic pain condition
called vulvodynia. Women who have been
diagnosed with vulvodynia or vestibulodynia,
or those with chronic pain around the opening of
the vagina with or without intercourse, may be
eligible to participate. Participation includes a
pelvic exam, sensitivity testing, one small blood
sample and one magnetic resonance imaging
(MRI) scan. Volunteers can be compensated
up to $210 for participating.
Info: (310) 825-5255 or email@example.com
For more information about Clinical Trials offered to
cancer patients, visit:
or call UCLA Jonsson Comprehensive Cancer Center (JCCC) Clinical
Trials Hotline at (888) 798-0719.