Clinical Trials

Research and Clinical Trials

Helpful Links

Information for Participants (UCLA OHRPP)
Understanding Clinical Trials (ClinicalTrials.gov)
UCLA Cancer Trials (UCLA JCCC)
Link to Non-Cancer Trials at UCLA

UCLA conducts research for a wide range of medical disorders and offers patients opportunities to participate in research and clinical trials.

Visit our Office of Clinical Trials website for more information about clinical trials.

Below are some featured trials at UCLA. Click here for a PDF of these trials. You may also visit the links to the right for additional trials from our clinical departments.


UCLA Aftercare Research Program

The Aftercare Research Program at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA will provide free treatment and assessment for participants in clinical research studies designed to improve understanding of psychotic disorders and develop more effective treatments. An initial diagnostic interview will determine a patient’s eligibility. The study will include individual case management, group therapy and treatment with an antipsychotic medication called risperidone. An initial period on risperidone is a requirement of this study; this may require changing the medications the patient may be taking prior to study enrollment. Patients' family members will be invited to join family psychoeducational meetings.
Info: (310) 206-3142 or email aftercare@mednet.ucla.edu, luana@ucla.edu or www.semel.ucla.edu/aftercare

UCLA Alcohol Clinical Trial

Is your drinking out of control? Have you thought about cutting back or quitting drinking? If so, you may be eligible to participate in a UCLA clinical trial studying a new medication for alcohol problems. Sponsored by the NIAAA Clinical Investigators Group (NCIG/NIAAA/NIH), this 28-week trial consists of study medication, outpatient clinic visits and monetary compensation. Study locations are available in both Westwood and Santa Monica.
Info: (310) 206-6756

Child Anxiety Study

The Child Anxiety Study, conducted by Susanna Chang, PhD, investigates the usefulness of a novel computer-based attention-training treatment for childhood anxiety. The study is seeking children ages 8 to 17 with social anxiety, generalized anxiety and separation anxiety. Parental participation is also required. The study involves four weeks of a non-medication attention-training treatment for children.
Info: (310) 825-2064

Child Attention & Real-World Emotion Study

Does your child have frequent worries or fears? UCLA is recruiting children between the ages of six and nine for a study about how attention may be related to the ability to manage emotions like anxiety or fear. The research study involves questionnaires and interviews about you and your child’s mood and behaviors, computer tasks assessing how your child processes emotional information (like facial expressions), recording your child’s brain waves while he/she views emotional information, two weekends of short (5-10 minute) phone interviews about your child’s activities and emotions and short (45-second) audio recordings of your child’s emotional expressions. The study also involves two visits to our research laboratory (about 3 hours total) and two weekends of phone calls. We will also ask parents to complete a few questionnaires six and 12 months after the final laboratory visit. Participants will receive compensation for their time and transportation costs. Interested families may be provided with clinical referrals. There are no medical risks associated with this study.
Info: (310) 835-2701

Coronary Artery Disease Treatment

This clinical trial compares the safety and efficacy of the Absorb BVS, an experimental absorbable stent that dissolves over one to two years, to Xience, a commercially available metallic stent. Eligible participants are adults with coronary artery disease who are scheduled to undergo interventional coronary artery procedures, have stable angina pectoris and require a heart catheterization with a high likelihood of needing a coronary angioplasty. Prior to the procedure, participants will complete an interview, blood tests, an electrocardiogram test and a health assessment questionnaire. Women of childbearing potential will also undergo a pregnancy test. During the procedure, all study participants will receive a coronary angiogram to evaluate the narrowed heart arteries and determine whether the volunteer can be registered in the study. Volunteers will meet with a registered dietician who will provide instructions on following an American Heart Association low-fat diet during the study. Participation in the study will last five to seven years and include up to 10 post-study visits. Follow up will include a telephone call or office visit after one, three, six and nine months, and at the end of each year. Study volunteers will be randomly assigned to treatment and will be informed of which stent they received at the end of the study.
Info: (310) 794-4797

Carotid Revascularization Endarterectomy versus Stenting Trial-2 (CREST-2)

CREST-2 is a multi-institutional randomized trial involving asymptomatic patients with hemodynamically significant carotid artery stenosis. Sponsored by the National Institutes of Health, this study is designed to test the hypothesis that intensive medical therapy is not inferior to invasive interventions such as carotid endarterectomy, carotid stent/angioplasty or intensive medical therapy in the prevention of stroke.
Info: (310) 206-1115

Late-Life Depression

For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy or loss of interest and pleasure in normal activities, UCLA is conducting a 12-month research study using an experimental combination of two drugs and a placebo (an inactive substance). The study seeks participants 60 years of age or older who are not currently receiving any psychiatric treatment with medications. Medical and psychiatric evaluations and limited physical exams are provided as a part of the study. Participants will undergo a PET scan and MRI scan. Evaluations and study medications are provided at no charge.
Info: (310) 794-9523 or (310) 983-3375

Depression in Older Adults

For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy, or loss of interest and pleasure in normal activities, UCLA is conducting a 12-month research study comparing levomilnacipran (FETZIMA®) to placebo (an inactive substance) for treatment of geriatric depression. If you are 60 years of age or older, you may qualify. A complete psychiatric evaluation, physical exam and MRI scan are provided as a part of the study. All participants will be given either levomilnacipran (FETZIMA®) or a placebo and will be compensated up to $200.
Info: (310) 794-9523 or (310) 794-4619

Effects of E-Cigarettes and Traditional Cigarettes on Arterial Inflammation

UCLA research study seeks healthy adults between the ages of 21-45 to test the effects of electronic (E)-cigarettes on blood vessel function and blood levels of anti-oxidants (protective compounds). Current tobacco cigarette smokers or current e-cigarette users may be eligible. No dual users. The study involves one visit, approximately 3.5 hours. Participants will undergo blood tests and a scan to measure blood vessel inflammation. Compensation is $100 at the completion of the study.
Info: (310) 825-3510

Effects of E-Cigarettes on Blood Vessel Function

UCLA is seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on blood vessel function. Must be a cigarette smoker, E-Cigarette user, or neither. Monetary compensation provided.
Info: (310) 825-3510 or kpeters@mednet.ucla.edu.

Effects of E-cigarettes on Sympathetic Nerve Activity

Seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on sympathetic nerve activity (nerves that carry adrenaline) and blood levels of anti-oxidants . Must be a NON-SMOKER or you must be an E-cigarette user. The study will involve either 1 two hour visit, or 3 two hour visits (depending on which group you're in) to the UCLA Clinical and Translational Research Center. Monetary compensation provided.
Info: (310) 825-3510 or kpeters@mednet.ucla.edu.

Heart Disease Treatment Study

The goal of the Heart Disease Treatment trial is to compare the safety and efficacy of Absorb, a naturally-dissolving, investigational stent, to XIENCE, an FDA-approved, commercially available metallic stent. Study researchers are seeking participants with coronary artery disease who are scheduled to undergo interventional coronary artery procedures. The trial will enroll approximately 3,000 subjects at 140 sites in the United States. Participation in the study will last five to seven years and will require up to 10 post-study visits, including a telephone call or office visit after one, three, six and nine months, and at the end of each year. Prior to the procedure, participants will complete an interview, blood tests, an electrocardiogram test and a health assessment questionnaire. Women of childbearing potential will also undergo a pregnancy test. During the procedure, all study subjects will receive a coronary angiogram to examine the narrowed heart arteries and determine whether the volunteer can be registered in the study. Study participants will meet with a registered dietician who will provide instructions on following an American Heart Association low-fat diet during the study. Study volunteers will be randomly assigned to treatment; they will find out which stent they have received at the end of the study.
Info: (310) 794-4797

Memory and Exercise Training (MET) Study

This project studies the relationship of simultaneous exercise and memory training. Volunteers 60 to 75 years of age who are in good health and living independently are encouraged to participate. The study will involve memory training, memory testing and physical exercise over the course of nine weeks. Subjects will be compensated for participation and will receive clinically relevant results of assessments.
Info: (310) 825-0545 or (310) 794-5020

Menstrual Irregularities and PCOS Study

UCLA researchers are seeking women with and without Polycystic Ovary Syndrome (PCOS). Participants must be 18- to 35-year-old females who are Caucasian or non-Hispanic, have body mass indices (BMI) between 18.5 and 25, and have not used hormones (i.e., birth control pills or a Mirena IUD) for the past three months. Participants will receive extensive medical testing (blood hormone measurements, diabetes screening and ovarian and fat assessments) at no charge. Blood will be drawn and a small amount of fat will be removed for research purposes. Only women with PCOS will take an oral pill that contains either the drug Flutamide or a placebo (sugar pill) for six complete 28-day cycles. Free medical testing will be repeated at the end of the study. Women without PCOS may be compensated up to $300 and women with PCOS may be compensated up to $840.
Info: (310) 825-7301 or uclaobgynresearch@mednet.ucla.edu

Family-focused Treatment for Childhood OCD

Does your child have Obsessive Compulsive Disorder (OCD)? Does he/she: Have recurring thoughts that make no sense, but makes him or her feel bad? Wash excessively or have fear of touching “contaminated” things? Check and double-check more than necessary? Have to do things over and over again? The study is seeking teens between the ages 8 and 17 years with OCD to participate in non-medication Cognitive Behavioral Therapy (CBT). Eligible participants will receive 14 weeks of free CBT treatment that includes .
Info: (310) 794-4347

Obstructive Sleep Apnea (OSA) Research Study

UCLA researchers are seeking patients between the ages of 21 and 75 who have recently been diagnosed with obstructive sleep apnea (and have not yet started treatment) to participate in a study examining how changes in brain function and structure relate to autonomic impairments. The study is also seeking healthy non-smokers without sleep disorders to serve as control subjects. People interested in participating will go through a screening process and those determined eligible will be enrolled in the study. Enrolled participants will be invited to do one or more of the following: Magnetic resonance imaging (MRI); physiological testing; simple, daily, home physiological testing; and brief questionnaires with a smart phone. Study participants will not be charged for any study procedures and will be compensated for their participation.
Info: (323) 362-8818 or projectdirector@osabrainresearch.org

Pomegranate Juice Study

The UCLA Longevity Center is studying the effects of pomegranate juice on memory. Volunteers between the ages of 50 and 75 are needed. The study lasts one year and includes five visits to UCLA and $300 compensation for participation.
Info: (310) 825-0545

Pomegranate Juice Study and Aging

The UCLA Center for Human Nutrition is studying the effects of pomegranate juice on aging. Female volunteers between the ages of 30 and 45 are needed. The study lasts twelve weeks and includes eight visits to UCLA and $475 compensation for participation.
Info: (310) 206-8292

Computerized Treatment for Stressed Kids and Teens

Does your child often feel scared, nervous, worried or stressed? Does your child excessively worry about school, peers or current events? Does he or she have fears of being embarrassed in social situations or get upset when separated from you? Does your child: Have recurring thoughts that make no sense, but make him or her feel bad? Wash or clean excessively or have fear of touching “contaminated” things? Check and double-check more than necessary? Have to do things over and over, including ask you for reassurance that things are ok? If you answered “yes” to any of these questions, and your child is between the ages of 10 and 17, your child may be eligible to receive a free computerized treatment for anxiety. Eligible youth will receive four weeks of a novel computer-based treatment that we think might help anxiety symptoms, as well as free diagnostic and cognitive assessments.
Info: (310) 794-2215

Tai-Chi or Health Education and Wellness for Older Adults

UCLA is seeking participants 60 years of age or older who are on stable medications for depression and are suffering from depressive symptoms and lack of energy to participate in a six-month research study. The trial involves 12 weekly 60-minute sessions that consist of either a health and education wellness class or a Tai-Chi class. Participants will undergo two functional magnetic resonance imaging (fMRI) scans and a complete psychiatric evaluation. Participants will be compensated.
Info: (310) 983-3375 or (310) 794-9523

Research to Help Children with Tourette Disorder

The UCLA Childhood OCD, Anxiety and Tic Disorders Program’s clinical trial aims to determine whether a medication improves the benefit of an evidence-based treatment for Habit Reversal Training (HRT), relative to a placebo pill. In order to qualify for this study, participants must be between the ages of 8 and 17, diagnosed with Tourette Disorder or Chronic Tic Disorder, and be medication-free or on a stable dose of medication with no planned changes. Participants will receive one session of HRT and referral information to continue to receive HRT from trained providers. Participation will involve an initial visit to UCLA to assess eligibility and tic severity, random assignment to receive a medication or placebo pill, an immediately subsequent session of HRT and a follow-up visit one week after the HRT session to evaluate tic severity. Compensation will be rendered, up to $90.
Info: (310) 794-5609

Undiagnosed Diseases Network

The Undiagnosed Diseases Network (UDN) is an initiative to facilitate the diagnosis of conditions that have eluded diagnosis. The UDN is made up of clinical and research centers across the United States that work together to improve diagnosis and care of patients with undiagnosed diseases. The UDN is accepting applications for patients and families affected by mysterious conditions. An in-depth review of medical records will determine eligibility for the UDN. If accepted, patients will undergo extensive genetic testing and comprehensive evaluations at UCLA.
Info: (310) 794-3695 or mherzog@mednet.ucla.edu or ndorrani@mednet.ucla.edu or undiagnosed.hms.harvard.edu/apply

Vulvodynia Research

UCLA researchers are seeking women aged 18 to 55 to help understand brain-activity changes associated with a chronic pain condition called vulvodynia. Women who have been diagnosed with vulvodynia or vestibulodynia, or those with chronic pain around the opening of the vagina with or without intercourse, may be eligible to participate. Participation includes a pelvic exam, sensitivity testing, one small blood sample and one magnetic resonance imaging (MRI) scan. Volunteers can be compensated up to $210 for participating.
Info: (310) 825-5255 or uclaobgynresearch@mednet.ucla.edu


For more information about Clinical Trials offered to cancer patients, visit:
www.cancer.ucla.edu/clinical-trials or call UCLA Jonsson Comprehensive Cancer Center (JCCC) Clinical Trials Hotline at (888) 798-0719.